Detailed information for compound 287130

Basic information

Technical information
  • TDR Targets ID: 287130
  • Name: 6,9-bis[2-[di(propan-2-yl)amino]ethylamino]be nzo[g]isoquinoline-5,10-dione
  • MW: 493.684 | Formula: C29H43N5O2
  • H donors: 2 H acceptors: 3 LogP: 6.14 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(N(C(C)C)CCNc1ccc(c2c1C(=O)c1cnccc1C2=O)NCCN(C(C)C)C(C)C)C
  • InChi: 1S/C29H43N5O2/c1-18(2)33(19(3)4)15-13-31-24-9-10-25(32-14-16-34(20(5)6)21(7)8)27-26(24)28(35)22-11-12-30-17-23(22)29(27)36/h9-12,17-21,31-32H,13-16H2,1-8H3
  • InChiKey: UJKGGJILFARNKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,9-bis[2-(diisopropylamino)ethylamino]benzo[g]isoquinoline-5,10-dione
  • 6,9-bis[2-(diisopropylamino)ethylamino]benzo[g]isoquinoline-5,10-quinone
  • 6,9-bis[2-(di(propan-2-yl)amino)ethylamino]benzo[g]isoquinoline-5,10-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.032 0.032
Onchocerca volvulus 0.0095 0.0094 0.0664
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0128 0.0151 0.1209
Schistosoma mansoni laminin gamma-3 chain 0.0095 0.0094 0.0753
Echinococcus multilocularis neural cadherin 0.0095 0.0094 0.1609
Brugia malayi ORL1-like opioid receptor 0.0074 0.0059 0.0475
Brugia malayi Melatonin receptor type 1A 0.0074 0.0059 0.0475
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Schistosoma mansoni amine GPCR 0.0074 0.0059 0.0475
Echinococcus granulosus neuropeptide receptor 0.0074 0.0059 0.1016
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0002 0.0037
Echinococcus granulosus protein jagged 2 0.0095 0.0094 0.1609
Echinococcus granulosus g protein coupled receptor 0.0074 0.0059 0.1016
Plasmodium falciparum basic transcription factor 3b, putative 0.0075 0.006 0.1025
Toxoplasma gondii PAN domain-containing protein 0.0104 0.011 0.1887
Onchocerca volvulus 0.0104 0.011 0.0796
Loa Loa (eye worm) PAN domain-containing protein 0.0104 0.011 0.0883
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.0059 0.1016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0171 0.2925
Echinococcus multilocularis allatostatin A receptor 0.0074 0.0059 0.1016
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0059 0.1016
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0038 0.0644
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.003 0.0244
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0328 0.5614
Echinococcus granulosus neuropeptide s receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) PAN domain-containing protein 0.0104 0.011 0.0883
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0059 0.0475
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0763 0.1248 1
Toxoplasma gondii microneme protein, putative 0.0104 0.011 0.1887
Brugia malayi Trypsin family protein 0.0763 0.1248 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Brugia malayi Cadherin domain containing protein 0.0095 0.0094 0.0753
Echinococcus granulosus laminin 0.0165 0.0216 0.3695
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.0111 1
Echinococcus granulosus neurogenic locus protein delta 0.0095 0.0094 0.1609
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Trypsin family protein 0.0128 0.0151 0.1209
Loa Loa (eye worm) hypothetical protein 0.0128 0.0151 0.1209
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0171 0.3901
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.006 0.541
Schistosoma mansoni hypothetical protein 0.0362 0.0556 0.4456
Schistosoma mansoni notch 0.0095 0.0094 0.0753
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0085 0.0078 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.0059 0.0475
Leishmania major basic transcription factor 3a, putative 0.0075 0.006 0.1025
Onchocerca volvulus 0.0074 0.0059 0.0384
Schistosoma mansoni histamine h1 receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Trypsin family protein 0.0128 0.0151 0.1209
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0123 0.0988
Onchocerca volvulus 0.0104 0.011 0.0796
Toxoplasma gondii PAN domain-containing protein 0.0104 0.011 0.1887
Loa Loa (eye worm) PAN domain-containing protein 0.0104 0.011 0.0883
Echinococcus multilocularis protein jagged 1 0.0095 0.0094 0.1609
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0085 0.0078 0.1331
Brugia malayi follicle stimulating hormone receptor 0.0566 0.0908 0.7276
Trypanosoma brucei transcription factor BTF3, putative 0.0075 0.006 0.1367
Toxoplasma gondii EGF family domain-containing protein 0.0095 0.0094 0.1609
Echinococcus multilocularis serotonin receptor 0.0074 0.0059 0.1016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0104 0.011 0.0883
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0085 0.0078 0.1775
Brugia malayi Serotonin receptor 0.0074 0.0059 0.0475
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0328 0.5614
Onchocerca volvulus 0.0095 0.0094 0.0664
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0059 0.0475
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Schistosoma mansoni hypothetical protein 0.0095 0.0094 0.0753
Leishmania major cysteinyl-tRNA synthetase, putative 0.0085 0.0078 0.1331
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0002 0.005
Schistosoma mansoni biogenic amine receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0165 0.0216 0.173
Brugia malayi Protein kinase domain containing protein 0.0379 0.0584 0.4682
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Schistosoma mansoni hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0165 0.0216 0.173
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Schistosoma mansoni neuropeptide receptor 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0074 0.0059 0.0384
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0059 0.1016
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0059 0.1016
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus granulosus neuropeptide receptor 0.0074 0.0059 0.1016
Echinococcus multilocularis Tolloid protein 1 0.0165 0.0216 0.3695
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0085 0.0078 0.0533
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Toxoplasma gondii PAN domain-containing protein 0.0104 0.011 0.1887
Echinococcus granulosus neurogenic locus notch protein 0.0095 0.0094 0.1609
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.0059 0.0475
Brugia malayi Muscle positioning protein 4 0.0095 0.0094 0.0753
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0059 0.0475
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0085 0.0078 0.0623
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.0038 0.0644
Onchocerca volvulus 0.0074 0.0059 0.0384
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0128 0.0151 0.2583
Toxoplasma gondii PAN domain-containing protein 0.0104 0.011 0.1887
Schistosoma mansoni hypothetical protein 0.0128 0.0151 0.1209
Onchocerca volvulus 0.0074 0.0059 0.0384
Loa Loa (eye worm) hypothetical protein 0.0128 0.0151 0.1209
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0057 0.0459
Loa Loa (eye worm) hypothetical protein 0.0128 0.0151 0.1209
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Echinococcus granulosus neural cadherin 0.0095 0.0094 0.1609
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0059 0.1016
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0085 0.0078 0.1331
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.006 0.1025
Echinococcus multilocularis lamin dm0 0.0058 0.003 0.052
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0095 0.0094 0.0664
Brugia malayi EGF-like domain containing protein 0.0095 0.0094 0.0753
Plasmodium vivax basic transcription factor 3b, putative 0.0075 0.006 0.1025
Onchocerca volvulus 0.0128 0.0151 0.1125
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.0059 0.1016
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0059 0.0475
Brugia malayi neuropeptide F receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0104 0.011 0.0883
Schistosoma mansoni lamin 0.0058 0.003 0.0243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0085 0.0078 0.0623
Onchocerca volvulus 0.0104 0.011 0.0796
Schistosoma mansoni neuropeptide receptor 0.0074 0.0059 0.0475
Toxoplasma gondii microneme protein MIC17A 0.0104 0.011 0.1887
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0059 0.1016
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0057 0.0459
Entamoeba histolytica hypothetical protein 0.0075 0.006 0.7701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.006 0.541
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0095 0.0094 0.0753
Schistosoma mansoni opsin-like receptor 0.0074 0.0059 0.0475
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.0059 0.0475
Onchocerca volvulus Neurogenic locus notch homolog 0.0095 0.0094 0.0664
Echinococcus multilocularis enteropeptidase 0.0363 0.0556 0.9527
Onchocerca volvulus 0.0128 0.0151 0.1125
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Toxoplasma gondii calcium binding egf domain-containing protein 0.0165 0.0216 0.3695
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Onchocerca volvulus 0.0095 0.0094 0.0664
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.0059 0.1016
Echinococcus multilocularis fat cadherin tumor suppressor 0.0095 0.0094 0.1609
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Loa Loa (eye worm) hypothetical protein 0.0104 0.011 0.0883
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.0059 0.0475
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5836 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0128 0.0151 0.1209
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0038 0.0644
Schistosoma mansoni hypothetical protein 0.0128 0.0151 0.1209
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.0059 0.0475
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0165 0.0216 0.173
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0128 0.0151 0.1209
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.0059 0.1016
Onchocerca volvulus 0.0128 0.0151 0.1125
Echinococcus granulosus g protein coupled receptor 0.0074 0.0059 0.1016
Onchocerca volvulus 0.0095 0.0094 0.0664
Brugia malayi AKH receptor 0.0074 0.0059 0.0475
Brugia malayi EGF-like domain containing protein 0.0095 0.0094 0.0753
Onchocerca volvulus 0.0104 0.011 0.0796
Schistosoma mansoni egf-like domain protein 0.0165 0.0216 0.173
Schistosoma mansoni retinoic acid receptor RXR 0.0133 0.016 0.1281
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0165 0.0216 0.173
Onchocerca volvulus 0.0074 0.0059 0.0384
Brugia malayi Calcium binding EGF domain containing protein 0.0165 0.0216 0.173
Schistosoma mansoni cell polarity protein 0.0095 0.0094 0.0753
Brugia malayi GCC2 and GCC3 family protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0059 0.0475
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0363 0.0556 0.446
Schistosoma mansoni hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.0059 0.0475
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0141 0.113
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0085 0.0078 0.1331
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Schistosoma mansoni amine GPCR 0.0074 0.0059 0.0475
Echinococcus granulosus leucyl tRNA synthetase 0.0085 0.0078 0.1331
Schistosoma mansoni notch 0.0095 0.0094 0.0753
Brugia malayi EGF-like domain containing protein 0.0095 0.0094 0.0753
Schistosoma mansoni opsin-like receptor 0.0074 0.0059 0.0475
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Echinococcus granulosus sex peptide receptor 0.0074 0.0059 0.1016
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.0059 0.1016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0059 0.1016
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0059 0.1016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Brugia malayi Delta serrate ligand family protein 0.0095 0.0094 0.0753
Echinococcus multilocularis transcription factor btf3 0.0075 0.006 0.1025
Schistosoma mansoni hypothetical protein 0.0074 0.0059 0.0475
Echinococcus granulosus glycoprotein Antigen 5 0.0363 0.0556 0.9527
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0104 0.011 0.1887
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.0059 0.0475
Toxoplasma gondii microneme protein MIC17C 0.0104 0.011 0.1887
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0085 0.0078 1
Toxoplasma gondii hypothetical protein 0.0104 0.011 0.1887
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Brugia malayi EGF-like domain containing protein 0.0095 0.0094 0.0753
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.0059 0.1016
Echinococcus granulosus neurogenic locus notch protein 0.0095 0.0094 0.1609
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0763 0.1248 1
Plasmodium vivax cysteine--tRNA ligase, putative 0.0085 0.0078 0.1331
Echinococcus multilocularis sex peptide receptor 0.0074 0.0059 0.1016
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.0059 0.0475
Echinococcus granulosus tissue type plasminogen activator 0.0379 0.0584 1
Brugia malayi Dopamine receptor protein 1 0.0074 0.0059 0.0475
Toxoplasma gondii PAN domain-containing protein 0.0104 0.011 0.1887
Echinococcus multilocularis slit 2 protein 0.0095 0.0094 0.1609
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0038 0.0644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0438 0.7498
Loa Loa (eye worm) intermediate filament protein 0.0058 0.003 0.0243
Schistosoma mansoni notch 0.0095 0.0094 0.0753
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0198 0.0198
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.0059 0.0384
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni slit 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Toxoplasma gondii hypothetical protein 0.0104 0.011 0.1887
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni hypothetical protein 0.0379 0.0584 0.4682
Schistosoma mansoni septate junction protein 0.0095 0.0094 0.0753
Onchocerca volvulus 0.0074 0.0059 0.0384
Onchocerca volvulus 0.0074 0.0059 0.0384
Onchocerca volvulus 0.0074 0.0059 0.0384
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0059 0.1016
Toxoplasma gondii hypothetical protein 0.0047 0.0013 0.0217
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.0059 0.0475
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Schistosoma mansoni biogenic amine receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus granulosus slit 2 protein 0.0095 0.0094 0.1609
Schistosoma mansoni hypothetical protein 0.0047 0.0012 0.0095
Toxoplasma gondii kringle domain-containing protein 0.0379 0.0584 1
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0059 0.1016
Echinococcus granulosus allatostatin A receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0104 0.011 0.0883
Brugia malayi beta-NAC-like protein 0.0075 0.006 0.048
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0128 0.0151 0.1209
Schistosoma mansoni transcription factor btf3 0.0075 0.006 0.048
Echinococcus multilocularis serotonin receptor 0.0074 0.0059 0.1016
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Schistosoma mansoni amine GPCR 0.0074 0.0059 0.0475
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0123 0.0988
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni intermediate filament proteins 0.0058 0.003 0.0243
Onchocerca volvulus 0.0074 0.0059 0.0384
Onchocerca volvulus 0.0128 0.0151 0.1125
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.003 0.0244
Echinococcus multilocularis protein jagged 1 0.0095 0.0094 0.1609
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Echinococcus multilocularis protein jagged 2 0.0095 0.0094 0.1609
Giardia lamblia Cysteinyl-tRNA synthetase 0.0085 0.0078 0.8271
Echinococcus granulosus protein jagged 2 0.0095 0.0094 0.1609
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.0038 0.0302
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0059 0.1016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0438 0.7498
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.0059 0.0384
Schistosoma mansoni hypothetical protein 0.0095 0.0094 0.0753
Schistosoma mansoni amine GPCR 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.0059 0.1016
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0085 0.0078 0.7025
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0059 0.1016
Echinococcus granulosus fmrfamide receptor 0.0074 0.0059 0.1016
Toxoplasma gondii NAC domain-containing protein 0.0075 0.006 0.1025
Loa Loa (eye worm) hypothetical protein 0.0104 0.011 0.0883
Echinococcus granulosus fibropellin Ia 0.0095 0.0094 0.1609
Schistosoma mansoni hypothetical protein 0.0095 0.0094 0.0753
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.0059 0.0475
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0128 0.0151 0.1209
Echinococcus granulosus delta-like protein 1 0.0095 0.0094 0.1609
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.0438 0.7498
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.0059 0.0475
Echinococcus multilocularis notch 0.0095 0.0094 0.1609
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.0059 0.0475
Echinococcus multilocularis fibropellin Ia 0.0095 0.0094 0.1609
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis orexin receptor type 2 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0058 0.003 0.0243
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi RE15519p 0.0074 0.0059 0.0475
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Schistosoma mansoni neuropeptide receptor 0.0074 0.0059 0.0475
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0171 0.2925
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.003 0.0243
Brugia malayi RNA binding protein 0.0073 0.0057 0.0459
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0085 0.0078 0.0623
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Brugia malayi Fibulin-1 precursor 0.0165 0.0216 0.173
Echinococcus multilocularis lamin 0.0058 0.003 0.052
Brugia malayi Calcium binding EGF domain containing protein 0.0095 0.0094 0.0753
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.0059 0.1016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Toxoplasma gondii microneme protein MIC17B 0.0104 0.011 0.1887
Schistosoma mansoni notch 0.0095 0.0094 0.0753
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0059 0.0475
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.0059 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0057 0.0459
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.5836 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.0059 0.0475
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Schistosoma mansoni notch 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0074 0.0059 0.0384
Schistosoma mansoni neuropeptide receptor 0.0074 0.0059 0.0475
Entamoeba histolytica transcription factor BTF3, putative 0.0075 0.006 0.7701
Onchocerca volvulus 0.0074 0.0059 0.0384
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.0059 0.1016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0012 0.0095
Loa Loa (eye worm) PAN domain-containing protein 0.0104 0.011 0.0883
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.0059 0.1016
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0085 0.0078 0.1331
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0057 0.0981
Mycobacterium ulcerans hypothetical protein 0.0128 0.0151 0.0151
Plasmodium falciparum glutathione reductase 0.0062 0.0038 0.0644
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0018 0.0305
Echinococcus granulosus lamin dm0 0.0058 0.003 0.052
Echinococcus granulosus notch 0.0095 0.0094 0.1609
Echinococcus multilocularis neurogenic locus notch protein 0.0095 0.0094 0.1609
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0085 0.0078 0.0623
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.0059 0.1016
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.0059 0.0475
Echinococcus multilocularis neurogenic locus protein delta 0.0095 0.0094 0.1609
Brugia malayi TAR-binding protein 0.0073 0.0057 0.0459
Schistosoma mansoni hypothetical protein 0.0095 0.0094 0.0753
Echinococcus multilocularis neurogenic locus protein delta 0.0095 0.0094 0.1609
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0128 0.0151 0.1209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Schistosoma mansoni hypothetical protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.003 0.0243
Echinococcus granulosus g protein coupled receptor 0.0074 0.0059 0.1016
Onchocerca volvulus 0.0058 0.003 0.015
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.0059 0.1016
Onchocerca volvulus 0.0104 0.011 0.0796
Echinococcus multilocularis Mastin 0.0363 0.0556 0.9527
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0057 0.0459
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0085 0.0078 1
Brugia malayi Thioredoxin reductase 0.0062 0.0038 0.0302
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.0059 0.1016
Onchocerca volvulus 0.0104 0.011 0.0796
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0123 0.2111
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0059 0.0475
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0165 0.0216 0.173
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0123 0.0143 0.2446
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Onchocerca volvulus 0.0074 0.0059 0.0384
Schistosoma mansoni notch 0.0095 0.0094 0.0753
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.0059 0.1016
Echinococcus granulosus neurogenic locus notch protein 4 0.0095 0.0094 0.1609
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus granulosus serotonin receptor 0.0074 0.0059 0.1016
Toxoplasma gondii PAN/Apple domain-containing protein 0.0104 0.011 0.1887
Loa Loa (eye worm) glutathione reductase 0.0062 0.0038 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.006 0.541
Toxoplasma gondii subtilisin SUB12 0.0104 0.011 0.1887
Loa Loa (eye worm) hypothetical protein 0.0097 0.0098 0.0785
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.0059 0.1016
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.0059 0.1016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0059 0.1016
Echinococcus multilocularis neurogenic locus notch protein 0.0095 0.0094 0.1609
Brugia malayi hypothetical protein 0.023 0.0328 0.2628
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Schistosoma mansoni hypothetical protein 0.0362 0.0556 0.4456
Brugia malayi Calcium binding EGF domain containing protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0059 0.0475
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0379 0.0584 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0059 0.1016
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Loa Loa (eye worm) PAN domain-containing protein 0.0104 0.011 0.0883
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi EGF-like domain containing protein 0.0095 0.0094 0.0753
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.0059 0.1016
Onchocerca volvulus Arrow homolog 0.0165 0.0216 0.1651
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.006 0.1025
Toxoplasma gondii calcium binding egf domain-containing protein 0.0165 0.0216 0.3695
Onchocerca volvulus 0.0104 0.011 0.0796
Onchocerca volvulus 0.0074 0.0059 0.0384
Schistosoma mansoni amine GPCR 0.0074 0.0059 0.0475
Echinococcus granulosus intermediate filament protein 0.0058 0.003 0.052
Echinococcus granulosus transcription factor btf3 0.0075 0.006 0.1025
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0002 0.0037
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0059 0.1016
Schistosoma mansoni adenoreceptor 0.0074 0.0059 0.0475
Brugia malayi EGF-like domain containing protein 0.0095 0.0094 0.0753
Schistosoma mansoni biogenic amine receptor 0.0074 0.0059 0.0475
Brugia malayi intermediate filament protein 0.0058 0.003 0.0243
Echinococcus granulosus geminin 0.0362 0.0556 0.9518
Onchocerca volvulus 0.0104 0.011 0.0796
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0128 0.0151 0.2583
Echinococcus granulosus hypothetical protein 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0165 0.0216 0.173
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0128 0.0151 0.2583
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Echinococcus granulosus Tolloid protein 1 0.0165 0.0216 0.3695
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0059 0.1016
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0059 0.1016
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.0438 1
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi sulfakinin receptor protein 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0074 0.0059 0.0384
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0059 0.1016
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0128 0.0151 0.1209
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0059 0.1016
Plasmodium falciparum cysteine repeat modular protein 1 0.0379 0.0584 1
Trypanosoma cruzi hypothetical protein, conserved 0.0379 0.0584 1
Chlamydia trachomatis cysteine--tRNA ligase 0.0085 0.0078 0.5
Onchocerca volvulus 0.0058 0.003 0.015
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.0059 0.1016
Onchocerca volvulus 0.0763 0.1248 1
Brugia malayi putative neuropeptide receptor 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0104 0.011 0.0796
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis geminin 0.0362 0.0556 0.9518
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0074 0.0059 0.0384
Echinococcus granulosus tar DNA binding protein 0.0073 0.0057 0.0981
Onchocerca volvulus 0.0104 0.011 0.0796
Loa Loa (eye worm) hypothetical protein 0.0058 0.003 0.0244
Echinococcus granulosus orexin receptor type 2 0.0074 0.0059 0.1016
Plasmodium falciparum cysteine--tRNA ligase 0.0085 0.0078 0.1331
Onchocerca volvulus 0.0074 0.0059 0.0384
Echinococcus multilocularis somatostatin receptor 0.0074 0.0059 0.1016
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.0059 0.1016
Brugia malayi Trypsin family protein 0.0128 0.0151 0.1209
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0057 0.0459
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0763 0.1248 1
Onchocerca volvulus Slit protein homolog 0.0095 0.0094 0.0664
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.0059 0.0475
Schistosoma mansoni opsin-like receptor 0.0074 0.0059 0.0475
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0002 0.0037
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.0059 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Brugia malayi G-protein coupled receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0104 0.011 0.0883
Onchocerca volvulus 0.0379 0.0584 0.4631
Brugia malayi glutathione reductase 0.0062 0.0038 0.0302
Schistosoma mansoni hypothetical protein 0.0095 0.0094 0.0753
Toxoplasma gondii PAN domain-containing protein 0.0104 0.011 0.1887
Echinococcus granulosus transmembrane protease serine 3 0.0128 0.0151 0.2583
Echinococcus granulosus lamin 0.0058 0.003 0.052
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0763 0.1248 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0057 0.0459
Giardia lamblia High cysteine protein 0.0095 0.0094 1
Onchocerca volvulus Putative cubilin 0.0095 0.0094 0.0664
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0141 0.113
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) notch protein 0.0095 0.0094 0.0753
Toxoplasma gondii microneme protein MIC4 0.0104 0.011 0.1887
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.0059 0.0475
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.0059 0.1016
Echinococcus granulosus enteropeptidase 0.0363 0.0556 0.9527
Echinococcus multilocularis fibrillin 1 0.0165 0.0216 0.3695
Schistosoma mansoni lamin 0.0058 0.003 0.0243
Brugia malayi GnHR receptor homolog 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis transmembrane protease serine 3 0.0128 0.0151 0.2583
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Cadherin domain containing protein 0.0095 0.0094 0.0753
Brugia malayi PAN domain containing protein 0.0104 0.011 0.0883
Brugia malayi hypothetical protein 0.0128 0.0151 0.1209
Echinococcus multilocularis glycoprotein Antigen 5 0.0363 0.0556 0.9527
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0085 0.0078 0.0623
Echinococcus granulosus somatostatin receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0165 0.0216 0.173
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0059 0.1016
Echinococcus multilocularis laminin 0.0165 0.0216 0.3695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0059 0.0475
Plasmodium falciparum thioredoxin reductase 0.0062 0.0038 0.0644
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Toxoplasma gondii thioredoxin reductase 0.0062 0.0038 0.0644
Loa Loa (eye worm) hypothetical protein 0.0379 0.0584 0.4682
Brugia malayi Trypsin-like protease protein 5 0.0128 0.0151 0.1209
Brugia malayi Serotonin receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0104 0.011 0.0883
Brugia malayi neuropeptide F receptor 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0636 0.1028 0.822
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0057 0.0459
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus granulosus g-protein coupled receptor 0.0074 0.0059 0.1016
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0057 0.0459
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0123 0.2111
Loa Loa (eye worm) hypothetical protein 0.0057 0.0029 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Schistosoma mansoni survival motor neuron protein 0.0047 0.0012 0.0095
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Echinococcus granulosus cysteinyl tRNA synthetase 0.0085 0.0078 0.1331
Loa Loa (eye worm) TK/ROR protein kinase 0.0379 0.0584 0.4682
Mycobacterium ulcerans hypothetical protein 0.0155 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.023 0.0328 0.2628
Plasmodium vivax glutathione reductase, putative 0.0062 0.0038 0.0644
Echinococcus multilocularis musashi 0.0058 0.003 0.052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0566 0.0908 0.7276
Loa Loa (eye worm) hypothetical protein 0.0128 0.0151 0.1209
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.0038 0.0038
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0165 0.0216 0.173
Loa Loa (eye worm) hypothetical protein 0.0165 0.0216 0.173
Schistosoma mansoni hypothetical protein 0.0095 0.0094 0.0753
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi notch-like transmembrane receptor 0.0095 0.0094 0.0753
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.0059 0.1016
Brugia malayi hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.003 0.0244
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Brugia malayi Dopamine receptor protein 2 0.0074 0.0059 0.0475
Loa Loa (eye worm) trypsin family protein 0.0128 0.0151 0.1209
Treponema pallidum cysteinyl-tRNA synthetase 0.0085 0.0078 1
Echinococcus granulosus protein jagged 1 0.0095 0.0094 0.1609
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi Dopamine receptor 0.0074 0.0059 0.0475
Brugia malayi Calcium binding EGF domain containing protein 0.0095 0.0094 0.0753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0059 0.1016
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.0059 0.0475
Loa Loa (eye worm) Notch2 0.0095 0.0094 0.0753
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0165 0.0216 0.173
Onchocerca volvulus 0.0104 0.011 0.0796
Echinococcus multilocularis neurogenic locus notch protein 4 0.0095 0.0094 0.1609
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0059 0.1016
Onchocerca volvulus 0.0095 0.0094 0.0664
Echinococcus granulosus Mastin 0.0363 0.0556 0.9527
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0059 0.1016
Brugia malayi EGF-like domain containing protein 0.0095 0.0094 0.0753
Leishmania major hypothetical protein, conserved 0.0379 0.0584 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0133 0.016 0.2737
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.0059 0.0475
Brugia malayi larval opioid receptor 0.0074 0.0059 0.0475
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.0059 0.0475
Schistosoma mansoni myosin xvIII 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Brugia malayi Kringle domain containing protein 0.0379 0.0584 0.4682
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0059 0.0475
Plasmodium falciparum cysteine--tRNA ligase 0.0085 0.0078 0.1331
Schistosoma mansoni cercarial elastase (S01 family) 0.0128 0.0151 0.1209
Trypanosoma brucei trypanothione reductase 0.0062 0.0038 0.0859
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0094 0.0753
Echinococcus multilocularis tissue type plasminogen activator 0.0379 0.0584 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Schistosoma mansoni hypothetical protein 0.0051 0.0018 0.0148
Echinococcus granulosus protein jagged 1 0.0095 0.0094 0.1609
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0059 0.1016
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.0059 0.0475
Onchocerca volvulus 0.0074 0.0059 0.0384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0059 0.0475
Leishmania major trypanothione reductase 0.0062 0.0038 0.0644
Onchocerca volvulus 0.0128 0.0151 0.1125
Loa Loa (eye worm) ICD-1 protein 0.0075 0.006 0.048
Brugia malayi G protein-coupled receptor 0.0074 0.0059 0.0475
Loa Loa (eye worm) RNA binding protein 0.0073 0.0057 0.0459
Loa Loa (eye worm) hypothetical protein 0.0074 0.0059 0.0475
Brugia malayi G-protein coupled receptor 0.0074 0.0059 0.0475
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0128 0.0151 0.2583

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.8 ug ml-1 Tested in vitro for inhibitory activity against L1210 murine leukemia ChEMBL. 8145234
IC50 (functional) = 1.8 ug ml-1 Tested in vitro for inhibitory activity against L1210 murine leukemia ChEMBL. 8145234
IC50 (functional) = 2.5 ug ml-1 Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo) ChEMBL. 8145234
IC50 (functional) = 2.5 ug ml-1 Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo) ChEMBL. 8145234
IC50 (functional) = 2.8 ug ml-1 Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line ChEMBL. 8145234
IC50 (functional) = 2.8 ug ml-1 Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line ChEMBL. 8145234
Ratio (functional) = 1.1 Resistance index is the ratio of IC50 of resistant cell line/IC50 of sensitive cell line ChEMBL. 8145234

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 8145234
Homo sapiens ChEMBL23 8145234

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.