Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Onchocerca volvulus | 0.0092 | 0.2914 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0092 | 0.2914 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0092 | 0.2914 | 0.2914 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0092 | 0.2914 | 0.2914 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0092 | 0.2914 | 0.2914 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0092 | 0.2914 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0092 | 0.2914 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0092 | 0.2914 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0092 | 0.2914 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0092 | 0.2914 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0092 | 0.2914 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0092 | 0.2914 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0092 | 0.2914 | 1 |
Brugia malayi | steroid hormone receptor | 0.0092 | 0.2914 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0092 | 0.2914 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0092 | 0.2914 | 0.2914 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0092 | 0.2914 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0092 | 0.2914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0092 | 0.2914 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0092 | 0.2914 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0092 | 0.2914 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0092 | 0.2914 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0092 | 0.2914 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0092 | 0.2914 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0092 | 0.2914 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0092 | 0.2914 | 0.2914 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0092 | 0.2914 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0092 | 0.2914 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0092 | 0.2914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0092 | 0.2914 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0092 | 0.2914 | 0.2914 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0092 | 0.2914 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0092 | 0.2914 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0092 | 0.2914 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0092 | 0.2914 | 0.2914 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0092 | 0.2914 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0092 | 0.2914 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0092 | 0.2914 | 0.2914 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0092 | 0.2914 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0092 | 0.2914 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0092 | 0.2914 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0092 | 0.2914 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0092 | 0.2914 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0092 | 0.2914 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0092 | 0.2914 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0092 | 0.2914 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0092 | 0.2914 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0092 | 0.2914 | 0.2914 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0092 | 0.2914 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0092 | 0.2914 | 0.2914 |
Schistosoma mansoni | coup transcription factor | 0.0092 | 0.2914 | 0.2914 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0092 | 0.2914 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0092 | 0.2914 | 0.2914 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0092 | 0.2914 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0092 | 0.2914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2914 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0092 | 0.2914 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0092 | 0.2914 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0092 | 0.2914 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0092 | 0.2914 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0092 | 0.2914 | 0.2914 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0092 | 0.2914 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0092 | 0.2914 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0092 | 0.2914 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.