Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0029 | 0.045 | 0.0137 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.045 | 0.0162 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0034 | 0.0588 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0588 | 0.1039 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0366 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0588 | 0.0428 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0914 | 0.1057 |
Echinococcus granulosus | carboxylesterase 5A | 0.0202 | 0.5555 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.5657 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0588 | 0.1039 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0629 | 0.0507 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0366 | 0.0646 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0202 | 0.5555 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0629 | 0.0507 |
Onchocerca volvulus | 0.0034 | 0.0588 | 0.0362 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0034 | 0.0588 | 0.0428 |
Echinococcus granulosus | neuroligin | 0.0034 | 0.0588 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0629 | 0.0507 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0588 | 0.1039 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.045 | 0.0162 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.01 | 0.2543 | 0.2043 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0588 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0366 | 0.0646 |
Onchocerca volvulus | 0.0034 | 0.0588 | 0.0362 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.045 | 0.0162 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Giardia lamblia | DNA repair protein RAD52 | 0.0352 | 1 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0418 | 0.0101 |
Onchocerca volvulus | 0.0034 | 0.0588 | 0.0362 | |
Entamoeba histolytica | hypothetical protein | 0.01 | 0.2543 | 0.2043 |
Schistosoma mansoni | gliotactin | 0.0034 | 0.0588 | 0.0428 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0034 | 0.0588 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0914 | 0.1057 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0034 | 0.0588 | 0.0428 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0914 | 0.1057 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0914 | 0.1616 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.5555 | 0.982 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.045 | 0.0162 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0914 | 0.1057 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.5555 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.5555 | 1 |
Onchocerca volvulus | 0.0234 | 0.6496 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0588 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0202 | 0.5555 | 0.982 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0366 | 0.0646 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.045 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0366 | 0.0646 |
Onchocerca volvulus | 0.0034 | 0.0588 | 0.0362 | |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0588 | 0.1039 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0034 | 0.0588 | 0.0428 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0588 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0588 | 0.1039 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.5555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.5555 | 0.982 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0351 | 0.0621 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0629 | 0.1112 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.045 | 0.0162 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.5657 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0202 | 0.5555 | 0.982 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0034 | 0.0588 | 0.0428 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0629 | 0.0507 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0588 | 0.1039 |
Loa Loa (eye worm) | carboxylesterase | 0.0202 | 0.5555 | 0.982 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0914 | 0.1057 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.045 | 0.0795 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0914 | 0.1057 |
Echinococcus multilocularis | neuroligin | 0.0034 | 0.0588 | 0.0428 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0034 | 0.0588 | 0.0428 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.045 | 0.0162 |
Schistosoma mansoni | acetylcholinesterase | 0.0034 | 0.0588 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.045 | 0.0795 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0914 | 0.1616 |
Onchocerca volvulus | 0.0034 | 0.0588 | 0.0362 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0914 | 0.1057 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.045 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0034 | 0.0588 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0202 | 0.5555 | 0.982 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0202 | 0.5555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0034 | 0.0588 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0034 | 0.0588 | 0.0428 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0588 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0588 | 0.1039 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.045 | 0.0162 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.5555 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.6496 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/I50 (functional) | NR 0 | Inhibition of 50% growth of tobacco callus derived from Nicotiana tabacum var on medium with 0.05 microM kinetin but without anti-cytokinin; NR=not reached to the maximum growth within the concentration range tested | ChEMBL. | 6854586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.