Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.08 | 0.08 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.08 | 0.08 |
Echinococcus granulosus | acetylcholinesterase | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0314 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0053 | 0.08 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.08 | 0.08 |
Onchocerca volvulus | 0.0053 | 0.08 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0314 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0053 | 0.08 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Echinococcus multilocularis | neuroligin | 0.0053 | 0.08 | 0.08 |
Echinococcus multilocularis | acetylcholinesterase | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0053 | 0.08 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0053 | 0.08 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0053 | 0.08 | 0.08 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.08 | 0.08 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0053 | 0.08 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0053 | 0.08 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0314 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0053 | 0.08 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0053 | 0.08 | 0.08 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.08 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.08 | 1 | |
Onchocerca volvulus | 0.0053 | 0.08 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0053 | 0.08 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0053 | 0.08 | 0.08 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.08 | 0.08 |
Brugia malayi | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.08 | 0.08 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0314 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.08 | 0.08 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.08 | 0.08 |
Echinococcus granulosus | acetylcholinesterase | 0.0314 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.08 | 0.08 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.08 | 0.08 |
Brugia malayi | Carboxylesterase family protein | 0.0314 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0053 | 0.08 | 0.08 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.08 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0053 | 0.08 | 0.08 |
Schistosoma mansoni | acetylcholinesterase | 0.0053 | 0.08 | 0.08 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0053 | 0.08 | 0.08 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0053 | 0.08 | 0.08 |
Onchocerca volvulus | 0.0053 | 0.08 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MAD (functional) | = 100 mg kg-1 | Anticonvulsant activity against tonic extension produced by maximal electroshock in mice, at 30 min postadministration | ChEMBL. | 2299648 |
MAD (functional) | = 100 mg kg-1 | Anticonvulsant activity against tonic extension produced by maximal electroshock in mice, at 30 min postadministration | ChEMBL. | 2299648 |
MED (functional) | > 300 mg kg-1 | Anticonvulsant activity against tonic extension produced by maximal electroshock in mice at 30 min postadministration | ChEMBL. | 2299648 |
MED (functional) | > 300 mg kg-1 | Anticonvulsant activity against tonic extension produced by maximal electroshock in mice at 30 min postadministration | ChEMBL. | 2299648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.