Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosylhomocysteinase | 0.0126 | 0.2331 | 0.1748 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0126 | 0.2331 | 0.1748 |
Echinococcus granulosus | adenosine deaminase | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.551 | 0.5169 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0284 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0284 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0284 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0284 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.551 | 0.5169 |
Leishmania major | adenine aminohydrolase | 0.0284 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0284 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0284 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0126 | 0.2331 | 0.1748 |
Schistosoma mansoni | AMP deaminase | 0.0093 | 0.0706 | 0.0706 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0126 | 0.2331 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0284 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0284 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0284 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0126 | 0.2331 | 0.1748 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0284 | 1 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0126 | 0.2331 | 0.1748 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0126 | 0.2331 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0126 | 0.2331 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0284 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0284 | 1 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0126 | 0.2331 | 0.1748 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0126 | 0.2331 | 0.1748 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0126 | 0.2331 | 0.1748 |
Schistosoma mansoni | adenosine deaminase-related | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.551 | 0.5169 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0126 | 0.2331 | 0.2331 |
Schistosoma mansoni | adenosine deaminase | 0.0284 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0126 | 0.2331 | 0.1748 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0126 | 0.2331 | 0.1748 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.551 | 0.5169 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0284 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.9 | Competitive inhibition of [3H]-spiperone binding to the human dopamine receptor D3 expressed in CHO cells, expressed as 10log Ki | ChEMBL. | 9083471 |
Log Ki (binding) | = 1.9 nM | Competitive inhibition of [3H]-spiperone binding to the human dopamine receptor D3 expressed in CHO cells, expressed as 10log Ki | ChEMBL. | 9083471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.