Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Muscarinic acetylcholine receptor M3 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Muscarinic acetylcholine receptor M3 | 587 aa | 504 aa | 26.8 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Muscarinic acetylcholine receptor M3 | 587 aa | 506 aa | 34.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0113 | 0.0023 | 0.0059 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3133 | 0.3832 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.8023 | 1 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.0012 | 0.003 |
Leishmania major | dihydroorotate dehydrogenase | 0.8023 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3133 | 0.3832 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3133 | 0.3832 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.0518 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0115 | 0.0025 | 0.0066 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.3133 | 0.3832 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3133 | 0.3832 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.8023 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.8023 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8023 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.8023 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3133 | 0.3832 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3133 | 0.3832 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3133 | 0.3832 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0153 | 0.0073 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.0518 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.8023 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.3133 | 0.3832 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8023 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8023 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.8023 | 1 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.0012 | 0.003 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.8023 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.8023 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8023 | 1 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0115 | 0.0025 | 0.0066 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.8023 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3133 | 0.3832 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3133 | 0.3832 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 0.0023 | 0.0059 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 5.61 | Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor | ChEMBL. | 2909747 |
Kd (functional) | = 6.79 | Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor | ChEMBL. | 2909747 |
pA2 (functional) | = 5.61 | Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor | ChEMBL. | 2909747 |
pA2 (functional) | = 6.79 | Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor | ChEMBL. | 2909747 |
Ratio (functional) | = 15 | Selectivity ratio between antagonistic potency in atria and ileum | ChEMBL. | 2909747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.