Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0385 | 0.1365 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0385 | 0.1365 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2281 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0385 | 0.1365 | 0.1365 |
Echinococcus granulosus | neuroligin | 0.0385 | 0.1365 | 0.1365 |
Brugia malayi | Carboxylesterase family protein | 0.0385 | 0.1365 | 0.1365 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0385 | 0.1365 | 0.1365 |
Echinococcus granulosus | acetylcholinesterase | 0.2281 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0385 | 0.1365 | 0.1365 |
Loa Loa (eye worm) | carboxylesterase | 0.2281 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0385 | 0.1365 | 0.1365 |
Brugia malayi | Carboxylesterase family protein | 0.0385 | 0.1365 | 0.1365 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0385 | 0.1365 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0385 | 0.1365 | 0.1365 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0162 | 0.0347 | 0.0347 |
Echinococcus multilocularis | acetylcholinesterase | 0.2281 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0385 | 0.1365 | 0.5 |
Brugia malayi | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Echinococcus granulosus | carboxylesterase 5A | 0.2281 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2281 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2281 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0385 | 0.1365 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2281 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0385 | 0.1365 | 0.1365 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Onchocerca volvulus | 0.0385 | 0.1365 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.2281 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0385 | 0.1365 | 0.1365 |
Brugia malayi | Carboxylesterase family protein | 0.0385 | 0.1365 | 0.1365 |
Onchocerca volvulus | 0.0385 | 0.1365 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0385 | 0.1365 | 0.1365 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0385 | 0.1365 | 0.1365 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Onchocerca volvulus | 0.0385 | 0.1365 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.2281 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0162 | 0.0347 | 0.0347 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0385 | 0.1365 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.1365 | 0.1365 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0385 | 0.1365 | 0.1365 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0385 | 0.1365 | 0.1365 |
Loa Loa (eye worm) | hypothetical protein | 0.2281 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0385 | 0.1365 | 0.1365 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0385 | 0.1365 | 0.1365 |
Loa Loa (eye worm) | carboxylesterase | 0.0385 | 0.1365 | 0.1365 |
Echinococcus multilocularis | neuroligin | 0.0385 | 0.1365 | 0.1365 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0385 | 0.1365 | 0.1365 |
Schistosoma mansoni | lipoxygenase | 0.0162 | 0.0347 | 0.0347 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0385 | 0.1365 | 0.1365 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0385 | 0.1365 | 0.5 |
Onchocerca volvulus | 0.0385 | 0.1365 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.2281 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K ass (binding) | = 80000 l M-1 | Apparent association constant of the compound against Coagulation factor II | ChEMBL. | 10715153 |
K ass (binding) | = 80000 l M-1 | Apparent association constant of the compound against Coagulation factor II | ChEMBL. | 10715153 |
K ass (binding) | = 3990000 l M-1 | Apparent association constant against coagulation factor X | ChEMBL. | 10715153 |
K ass (binding) | = 3990000 l M-1 | Apparent association constant against coagulation factor X | ChEMBL. | 10715153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.