TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 257.645 | Formula: C11H9ClFNO3
H donors: 1 H acceptors: 2 LogP: 2.34 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C(=N)/C=C(/c1ccc(c(c1)Cl)F)\O
InChi: 1S/C11H9ClFNO3/c1-17-11(16)9(14)5-10(15)6-2-3-8(13)7(12)4-6/h2-5,14-15H,1H3/b10-5-,14-9?
InChiKey: WERFMBBJFFIZIC-BIIQMUQRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0027	0.0999	0.1199
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0999	0.1091
Onchocerca volvulus		0.0108	0.6707	0.9781
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0381	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0019	0.0495	0.0334
Brugia malayi	Dihydrofolate reductase	0.0045	0.2281	0.238
Echinococcus granulosus	lamin	0.0027	0.0999	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1351	0.1474
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0495	0.0521
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0033	0.1449	0.16
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Brugia malayi	hypothetical protein	0.0015	0.0202	0.0076
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.2082	0.6869
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.1633	0.1631
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0033	0.1449	0.155
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0019	0.0495	0.054
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0637	0.0704
Onchocerca volvulus		0.0108	0.6707	0.9781
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0033	0.1449	0.16
Echinococcus multilocularis	glycine receptor subunit beta	0.0033	0.1449	0.155
Brugia malayi	hypothetical protein	0.0052	0.2806	0.2961
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Schistosoma mansoni	glucose transport protein	0.0019	0.0495	0.0366
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0019	0.0495	0.0505
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0033	0.1449	0.1427
Trypanosoma brucei	sugar transporter, putative	0.0019	0.0495	0.0334
Brugia malayi	hypothetical protein	0.0019	0.0495	0.0401
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0033	0.1449	0.16
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0018	0.0381	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0999	0.1091
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0033	0.1449	0.1458
Echinococcus granulosus	solute carrier family 22	0.0019	0.0495	0.0521
Loa Loa (eye worm)	thymidylate synthase	0.011	0.6853	0.7481
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Brugia malayi	Sugar transporter family protein	0.0019	0.0495	0.0401
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0316	0.0153
Schistosoma mansoni	sugar transporter	0.0019	0.0495	0.0366
Onchocerca volvulus		0.0019	0.0495	0.044
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0155	1	1
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	ACC-1 protein	0.0033	0.1449	0.1582
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0202	0.0076
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0033	0.1449	0.155
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0637	0.0478
Entamoeba histolytica	hypothetical protein	0.0036	0.1633	0.878
Loa Loa (eye worm)	hypothetical protein	0.0093	0.5639	0.6156
Onchocerca volvulus		0.011	0.6853	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0108	0.6707	0.7272
Onchocerca volvulus		0.0019	0.0495	0.044
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0033	0.1449	0.155
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.1633	0.1808
Onchocerca volvulus		0.0019	0.0495	0.044
Loa Loa (eye worm)	acetyltransferase	0.0143	0.916	1
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0637	0.1056
Brugia malayi	Cation transporter family protein	0.0033	0.1449	0.1458
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.2082	0.2316
Onchocerca volvulus		0.0019	0.0495	0.044
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.011	0.6853	1
Onchocerca volvulus		0.0018	0.0381	0.027
Echinococcus multilocularis	musashi	0.0027	0.0999	0.1058
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0381	0.0275
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0019	0.0495	0.0492
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0033	0.1449	0.1427
Loa Loa (eye worm)	ACC-1 protein	0.0033	0.1449	0.1582
Echinococcus granulosus	nAChR subunit	0.0033	0.1449	0.16
Loa Loa (eye worm)	GABA receptor subunit	0.0018	0.0381	0.0416
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.1449	0.1458
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0033	0.1449	0.155
Brugia malayi	Major Facilitator Superfamily protein	0.0019	0.0495	0.0401
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.1633	0.1752
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Brugia malayi	Sugar transporter family protein	0.0019	0.0495	0.0401
Brugia malayi	hypothetical protein	0.0015	0.0202	0.0076
Echinococcus multilocularis	dihydrofolate reductase	0.0045	0.2281	0.2462
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0045	0.2281	0.281
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0033	0.1449	0.16
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0019	0.0495	0.0505
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0019	0.0495	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.2806	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0495	0.0521
Brugia malayi	Cation transporter family protein	0.0033	0.1449	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Onchocerca volvulus		0.0033	0.1449	0.1875
Brugia malayi	major facilitator superfamily protein	0.0019	0.0495	0.0401
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0019	0.0495	0.0334
Trypanosoma brucei	unspecified product	0.0035	0.1592	0.145
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.1592	0.145
Onchocerca volvulus		0.0027	0.0999	0.1199
Schistosoma mansoni	nAChR subunit	0.0033	0.1449	0.1427
Echinococcus granulosus	solute carrier family 22	0.0019	0.0495	0.0521
Echinococcus granulosus	intermediate filament protein	0.0027	0.0999	0.1091
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0999	0.096
Schistosoma mansoni	lamin	0.0027	0.0999	0.0926
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0042	0.2062	0.6783
Brugia malayi	hypothetical protein	0.0015	0.0202	0.0076
Schistosoma mansoni	nAChR subunit	0.0033	0.1449	0.1427
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0316	0.0153
Brugia malayi	polk-prov protein	0.0032	0.1351	0.1349
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0155	1	1
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0033	0.1449	0.1458
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0033	0.1449	0.155
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Leishmania major	glucose transporter, lmgt3	0.0019	0.0495	0.0334
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0015	0.0202	0.019
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.2082	0.167
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.2082	0.167
Brugia malayi	Sugar transporter family protein	0.0019	0.0495	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Loa Loa (eye worm)	sugar transporter	0.0019	0.0495	0.054
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Echinococcus multilocularis	dna polymerase eta	0.0015	0.0166	0.0145
Schistosoma mansoni	nAChR subunit	0.0033	0.1449	0.1427
Echinococcus granulosus	nAChR subunit	0.0018	0.0381	0.0392
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0015	0.0202	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0052	0.2806	0.2684
Schistosoma mansoni	sugar transporter	0.0019	0.0495	0.0366
Onchocerca volvulus	Putative nachr subunit	0.0033	0.1449	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0037
Entamoeba histolytica	hypothetical protein	0.0036	0.1633	0.878
Schistosoma mansoni	lamin	0.0027	0.0999	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Trichomonas vaginalis	DNA polymerase eta, putative	0.0042	0.2062	0.6783
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.1351	0.1204
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0033	0.1449	0.1427
Trypanosoma cruzi	hexose transporter	0.0019	0.0495	0.0334
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Chlamydia trachomatis	dihydrofolate reductase	0.0045	0.2281	0.5
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0019	0.0495	0.0505
Schistosoma mansoni	hypothetical protein	0.0019	0.0495	0.0366
Schistosoma mansoni	dihydrofolate reductase	0.0045	0.2281	0.2352
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.1449	0.1458
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0015	0.0202	0.0184
Onchocerca volvulus		0.0019	0.0495	0.044
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0033	0.1449	0.1458
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0015	0.0202	0.0076
Schistosoma mansoni	nAChR subunit	0.0033	0.1449	0.1427
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0033	0.1449	0.16
Onchocerca volvulus		0.0108	0.6707	0.9781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.916	1
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.2062	0.2222
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0033	0.1449	0.1458
Schistosoma mansoni	nAChR subunit	0.0033	0.1449	0.1427
Echinococcus granulosus	solute carrier family 22	0.0019	0.0495	0.0521
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0202	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Echinococcus granulosus	lamin dm0	0.0027	0.0999	0.1091
Echinococcus multilocularis	thymidylate synthase	0.011	0.6853	0.7472
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0033	0.1449	0.1458
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0015	0.0166	0.0149
Echinococcus granulosus	glycine receptor subunit beta	0.0033	0.1449	0.16
Schistosoma mansoni	sugar transporter	0.0019	0.0495	0.0366
Schistosoma mansoni	neurotransmitter gated ion channel	0.0015	0.0202	0.004
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0033	0.1449	0.1582
Brugia malayi	hypothetical protein	0.0019	0.0495	0.0401
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0033	0.1449	0.155
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Leishmania major	hypothetical protein, conserved	0.0019	0.0495	0.0334
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0108	0.6707	0.7272
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0015	0.0202	0.0076
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0033	0.1449	0.155
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0019	0.0495	0.0492
Brugia malayi	hypothetical protein	0.0015	0.0202	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.2082	0.6869
Onchocerca volvulus		0.0019	0.0495	0.044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.2062	0.1928
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0015	0.0202	0.022
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0033	0.1449	0.155
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0033	0.1449	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Schistosoma mansoni	glucose transporter	0.0019	0.0495	0.0366
Echinococcus multilocularis	lamin dm0	0.0027	0.0999	0.1058
Schistosoma mansoni	hypothetical protein	0.0036	0.1633	0.1631
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.916	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Onchocerca volvulus		0.0019	0.0495	0.044
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Echinococcus granulosus	synaptic vesicle 2 protein	0.0019	0.0495	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Echinococcus multilocularis	nAChR subunit	0.0018	0.0381	0.038
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.1837	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0033	0.1449	0.1582
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0019	0.0495	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Schistosoma mansoni	acetylcholine receptor-related	0.0015	0.0202	0.004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0637	0.0478
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0033	0.1449	0.16
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.1449	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0133	0.0145
Onchocerca volvulus		0.0019	0.0495	0.044
Onchocerca volvulus		0.0019	0.0495	0.044
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.2062	0.2466
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0033	0.1449	0.1458
Schistosoma mansoni	glucose transport protein	0.0019	0.0495	0.0366
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0015	0.0202	0.004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.1449	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0033	0.1449	0.1427
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0999	0.1091
Brugia malayi	dihydrofolate reductase family protein	0.0045	0.2281	0.238
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0202	0.0076
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0033	0.1449	0.16
Echinococcus granulosus	dna polymerase kappa	0.0042	0.2062	0.2293
Onchocerca volvulus		0.0019	0.0495	0.044
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0019	0.0495	0.0505
Echinococcus granulosus	dna polymerase eta	0.0015	0.0166	0.0149
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0015	0.0166	0.0145
Echinococcus granulosus	dihydrofolate reductase	0.0045	0.2281	0.2541
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0381	0.0416
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0033	0.1449	0.1582
Schistosoma mansoni	neurotransmitter gated ion channel	0.0018	0.0381	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Onchocerca volvulus		0.0019	0.0495	0.044
Loa Loa (eye worm)	hypothetical protein	0.0108	0.6707	0.7322
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0033	0.1449	0.16
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0495	0.0505
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Schistosoma mansoni	nAChR subunit	0.0015	0.0202	0.004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.1449	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.1449	0.1458
Leishmania major	myo-inositol/proton symporter (MIT)	0.0019	0.0495	0.0334
Leishmania major	glucose transporter, lmgt1	0.0019	0.0495	0.0334
Trypanosoma brucei	glucose transporter 1E	0.0019	0.0495	0.0334
Loa Loa (eye worm)	acetylcholine receptor protein	0.0015	0.0202	0.022
Mycobacterium tuberculosis	Hypothetical protein	0.0052	0.2806	0.3948
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0637	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0166	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0965	0.1054
Trypanosoma brucei	glucose transporter 2A	0.0019	0.0495	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0495	0.0505
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0155	1	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.011	0.6853	0.7434
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.2062	0.1928
Schistosoma mansoni	nAChR subunit	0.0033	0.1449	0.1427
Mycobacterium ulcerans	thymidylate synthase	0.011	0.6853	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Onchocerca volvulus		0.0019	0.0495	0.044
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0033	0.1449	0.1458
Brugia malayi	excitatory GABA receptor EXP-1A	0.0033	0.1449	0.1458
Leishmania major	glucose transporter, lmgt2	0.0019	0.0495	0.0334
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.2082	0.167
Trypanosoma cruzi	glucose transporter, putative	0.0019	0.0495	0.0334
Brugia malayi	thymidylate synthase	0.011	0.6853	0.7444
Brugia malayi	major facilitator superfamily protein	0.0019	0.0495	0.0401
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0033	0.1449	0.155
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0045	0.2281	0.3163
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0033	0.1449	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Brugia malayi	Major Facilitator Superfamily protein	0.0019	0.0495	0.0401
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.1837	1
Echinococcus granulosus	glycine receptor subunit beta	0.0033	0.1449	0.16
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0202	0.022
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.2062	0.2466
Brugia malayi	Major Facilitator Superfamily protein	0.0019	0.0495	0.0401
Onchocerca volvulus	Putative transporter	0.0019	0.0495	0.044
Loa Loa (eye worm)	LGC-31 protein	0.0033	0.1449	0.1582
Brugia malayi	hypothetical protein	0.0036	0.1633	0.1661
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0495	0.0505
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Schistosoma mansoni	nAChR subunit	0.0015	0.0202	0.004
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0166	0.0036
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.8879	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0019	0.0495	0.0334
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0495	0.0334
Onchocerca volvulus		0.0019	0.0495	0.044
Onchocerca volvulus		0.0018	0.0381	0.027
Schistosoma mansoni	nAChR subunit	0.0033	0.1449	0.1427
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0202	0.019
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.916	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0033	0.1449	0.1458
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0033	0.1449	0.1458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0316	0.0153
Onchocerca volvulus		0.0033	0.1449	0.1875
Brugia malayi	intermediate filament protein	0.0027	0.0999	0.096
Trypanosoma cruzi	sugar transporter, putative	0.0019	0.0495	0.0334
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0999	0.0926
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0018	0.0381	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Echinococcus multilocularis	glycine receptor subunit beta	0.0033	0.1449	0.155
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0018	0.0381	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0033	0.1449	0.1582
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0033	0.1449	0.16
Onchocerca volvulus		0.0019	0.0495	0.044
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0019	0.0495	0.5
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0033	0.1449	0.16
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0033	0.1449	0.16
Trypanosoma brucei	glucose transporter, putative	0.0019	0.0495	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Brugia malayi	hypothetical protein	0.0019	0.0495	0.0401
Entamoeba histolytica	hypothetical protein	0.0036	0.1633	0.878
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.1351	0.1204
Brugia malayi	hypothetical protein	0.0015	0.0202	0.0076
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0202	0.0076
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0019	0.0495	0.054
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0033	0.1449	0.1582
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0155	1	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0019	0.0495	0.0505
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.2062	0.1928
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Echinococcus multilocularis	lamin	0.0027	0.0999	0.1058
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0033	0.1449	0.155
Onchocerca volvulus		0.0019	0.0495	0.044
Loa Loa (eye worm)	sugar transporter	0.0019	0.0495	0.054
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0202	0.022
Entamoeba histolytica	hypothetical protein	0.0036	0.1633	0.878
Schistosoma mansoni	glucose transport protein	0.0019	0.0495	0.0366
Echinococcus granulosus	thymidylate synthase	0.011	0.6853	0.7709
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0166	0.0036
Schistosoma mansoni	neurotransmitter gated ion channel	0.0015	0.0202	0.004
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0019	0.0495	0.0505
Brugia malayi	Cation transporter family protein	0.0108	0.6707	0.7282
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0015	0.0166	0.0181
Onchocerca volvulus		0.0019	0.0495	0.044
Entamoeba histolytica	hypothetical protein	0.0018	0.0381	0.1287
Schistosoma mansoni	sugar transporter	0.0019	0.0495	0.0366
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0019	0.0495	0.0334
Onchocerca volvulus		0.0033	0.1449	0.1875
Echinococcus multilocularis	solute carrier family 22	0.0019	0.0495	0.0505
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0015	0.0202	0.0076
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.011	0.6853	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0495	0.054
Echinococcus multilocularis	nAChR subunit	0.0033	0.1449	0.155
Loa Loa (eye worm)	hypothetical protein	0.0108	0.6707	0.7322
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0495	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1449	0.1582
Echinococcus granulosus	solute carrier family 22	0.0019	0.0495	0.0521
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0019	0.0495	0.0521
Loa Loa (eye worm)	dihydrofolate reductase	0.0045	0.2281	0.249
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.1837	0.1412
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0381	0.0239

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 4 %	Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver at 10 microM	ChEMBL.	10633043
Inhibition (binding)	= 4 %	Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver at 10 microM	ChEMBL.	10633043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 28821