Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.043 |
Leishmania major | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.043 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0043 | 0.0759 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0074 | 0.2622 | 1 |
Echinococcus multilocularis | geminin | 0.0196 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0045 | 0.0839 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0045 | 0.0839 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Echinococcus granulosus | dna polymerase eta | 0.0074 | 0.2622 | 0.1947 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0045 | 0.0839 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0045 | 0.0839 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0839 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Giardia lamblia | DINP protein human, muc B family | 0.0045 | 0.0839 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0839 | 0.3199 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0045 | 0.0839 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.043 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.043 |
Echinococcus multilocularis | dna polymerase eta | 0.0074 | 0.2622 | 0.1947 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2622 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0045 | 0.0839 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0839 | 0.3199 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0045 | 0.0839 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0045 | 0.0839 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0074 | 0.2622 | 0.1947 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0074 | 0.2622 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0074 | 0.2622 | 1 |
Trypanosoma brucei | unspecified product | 0.0045 | 0.0839 | 0.3199 |
Leishmania major | DNA polymerase eta, putative | 0.0074 | 0.2622 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.3199 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.0839 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 46 mg kg-1 | Antiinflammatory activity was determined by inhibition of carrageenan-induced edema in rat paw with respect to phenylbutazone | ChEMBL. | 3572970 |
ED50 (functional) | = 121 mg kg-1 | Analgesic activity in mice by phenyl quinone-induced writhing assay with respect to aspirin. | ChEMBL. | 3572970 |
ED50 (functional) | = 121 mg kg-1 | Analgesic activity in mice by phenyl quinone-induced writhing assay with respect to aspirin. | ChEMBL. | 3572970 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.