Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1035 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0188 | 0.0188 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1035 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1035 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1035 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1035 | 1 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0048 | 0.0048 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1035 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0027 | 0.0027 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.1035 | 1 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0042 | 0.03 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0188 | 0.0188 |
Echinococcus multilocularis | protein patched | 0.0426 | 0.4051 | 0.4051 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0188 | 0.0188 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0485 | 0.4631 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1035 | 1 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.03 | 0.03 |
Onchocerca volvulus | 0.0031 | 0.0188 | 1 | |
Echinococcus multilocularis | lamin | 0.0031 | 0.0188 | 0.0188 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0485 | 0.4631 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0183 | 0.0183 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0042 | 0.03 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0027 | 0.0027 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.03 | 0.03 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0426 | 0.4051 | 0.4051 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0485 | 0.4631 | 1 |
Brugia malayi | CHE-14 protein | 0.0426 | 0.4051 | 0.4051 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.4051 | 0.8659 |
Echinococcus multilocularis | protein dispatched 1 | 0.0426 | 0.4051 | 0.4051 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1035 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0188 | 0.0188 |
Onchocerca volvulus | 0.0031 | 0.0188 | 1 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.0426 | 0.4051 | 0.4051 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0042 | 0.03 | 0.03 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.03 | 0.03 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0188 | 0.0188 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0032 | 0.0032 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0042 | 0.03 | 0.03 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0032 | 0.0032 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0042 | 0.03 | 0.03 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0426 | 0.4051 | 0.4051 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0426 | 0.4051 | 0.4051 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0426 | 0.4051 | 0.4051 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0032 | 0.0032 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0188 | 0.0188 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0426 | 0.4051 | 0.4051 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.4051 | 0.4051 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0426 | 0.4051 | 0.4051 |
Schistosoma mansoni | lamin | 0.0031 | 0.0188 | 0.0188 |
Echinococcus granulosus | lamin | 0.0031 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0188 | 0.0188 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.03 | 0.03 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0042 | 0.03 | 0.03 |
Schistosoma mansoni | patched 1 | 0.0426 | 0.4051 | 0.4051 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.03 | 0.03 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0485 | 0.4631 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.06 uM | Binding affinity towards human recombinant adenosine A2A receptor by displacement of [3H]-SCH-58,261 radioligand. | ChEMBL. | 14741297 |
Ki (binding) | = 0.06 uM | Binding affinity towards human recombinant adenosine A2A receptor by displacement of [3H]-SCH-58,261 radioligand. | ChEMBL. | 14741297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.