Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.0499 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0499 | 0.0329 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0101 | 0.2883 | 1 |
Onchocerca volvulus | 0.0062 | 0.0175 | 0.5 | |
Brugia malayi | Thioredoxin reductase | 0.0204 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0499 | 0.0499 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0204 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0204 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.0499 | 0.0499 |
Toxoplasma gondii | thioredoxin reductase | 0.0204 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0204 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0204 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0204 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0071 | 0.0752 | 0.0752 |
Plasmodium falciparum | thioredoxin reductase | 0.0204 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0204 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0071 | 0.0752 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0141 | 0.5628 | 0.5628 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0071 | 0.0752 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.0499 | 0.0499 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.0499 | 0.0499 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.0499 | 0.0329 |
Leishmania major | trypanothione reductase | 0.0204 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0204 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0071 | 0.0752 | 0.0587 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0204 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0071 | 0.0752 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0141 | 0.5628 | 0.5628 |
Echinococcus multilocularis | serotonin transporter | 0.0062 | 0.0175 | 0.0175 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0101 | 0.2883 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.0499 | 0.0499 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0062 | 0.0175 | 0.0175 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0101 | 0.2883 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0101 | 0.2883 | 0.2304 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0071 | 0.0752 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.0499 | 0.0329 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.0499 | 0.0499 |
Treponema pallidum | NADH oxidase | 0.0071 | 0.0752 | 0.2131 |
Chlamydia trachomatis | glutamine binding protein | 0.0101 | 0.2883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0499 | 0.0329 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0499 | 0.0329 |
Plasmodium falciparum | glutathione reductase | 0.0204 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0141 | 0.5628 | 0.5628 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0071 | 0.0752 | 0.0752 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0071 | 0.0752 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0204 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0071 | 0.0752 | 0.0752 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0071 | 0.0752 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0499 | 0.0329 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0062 | 0.0175 | 0.0175 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0101 | 0.2883 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0062 | 0.0175 | 0.0175 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 37 % | Inhibition of passive cutaneous anaphylaxis following 1 mg/kg p.o. administration. | ChEMBL. | 6229634 |
Inhibition (functional) | = 65 % | Inhibition of passive cutaneous anaphylaxis following 3 mg/kg p.o. administration. | ChEMBL. | 6229634 |
Inhibition (functional) | = 72 % | Inhibition of passive cutaneous anaphylaxis following 3 mg/kg p.o. (5 min pretreatment) administration. | ChEMBL. | 6229634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.