Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | caspase | 0.0587 | 0.7381 | 0.7224 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.016 | 0.1129 | 0.1129 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Loa Loa (eye worm) | fibroinase | 0.0121 | 0.0565 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0565 | 0.0565 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Loa Loa (eye worm) | ctsf protein | 0.0121 | 0.0565 | 0.0565 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0121 | 0.0565 | 0.0565 |
Onchocerca volvulus | 0.0121 | 0.0565 | 0.0565 | |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0449 | 0.5363 | 1 |
Brugia malayi | hypothetical protein | 0.0238 | 0.2271 | 0.2271 |
Plasmodium vivax | hypothetical protein, conserved | 0.0303 | 0.3226 | 0.5546 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0565 | 0.1054 |
Echinococcus multilocularis | cathepsin b | 0.016 | 0.1129 | 0.0597 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Onchocerca volvulus | 0.0322 | 0.351 | 0.351 | |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0449 | 0.5363 | 0.5363 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.0565 | 0.0565 |
Mycobacterium ulcerans | proteasome PrcB | 0.0449 | 0.5363 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0303 | 0.3226 | 0.5546 |
Brugia malayi | hypothetical protein | 0.0322 | 0.351 | 0.351 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0303 | 0.3226 | 0.6016 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0587 | 0.7381 | 0.7224 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0121 | 0.0565 | 0.0565 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.016 | 0.1129 | 0.1129 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0449 | 0.5363 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0121 | 0.0565 | 0.0565 |
Trypanosoma brucei | metacaspase | 0.0303 | 0.3226 | 0.5546 |
Echinococcus granulosus | caspase 3 | 0.0284 | 0.295 | 0.295 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0303 | 0.3226 | 0.3226 |
Echinococcus multilocularis | caspase 2 | 0.0766 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0121 | 0.0565 | 0.0565 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0587 | 0.7381 | 0.7381 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0303 | 0.3226 | 0.3226 |
Echinococcus multilocularis | caspase 8 | 0.0303 | 0.3226 | 0.282 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0121 | 0.0565 | 0.1054 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0449 | 0.5363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.351 | 0.351 |
Trypanosoma cruzi | metacaspase, putative | 0.0303 | 0.3226 | 0.6016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0587 | 0.7381 | 0.7381 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Onchocerca volvulus | Cathepsin F homolog | 0.0121 | 0.0565 | 0.0565 |
Echinococcus granulosus | cathepsin l1 | 0.0121 | 0.0565 | 0.0565 |
Trypanosoma brucei | metacaspase 5, putative | 0.0303 | 0.3226 | 0.5546 |
Plasmodium vivax | metacaspase 1, putative | 0.0303 | 0.3226 | 0.5546 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0303 | 0.3226 | 0.6016 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0303 | 0.3226 | 0.6016 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.0565 | 0.0565 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0303 | 0.3226 | 0.6016 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 0.1129 | 0.1129 |
Trypanosoma brucei | Metacaspase-4 | 0.0303 | 0.3226 | 0.5546 |
Echinococcus granulosus | cathepsin b | 0.016 | 0.1129 | 0.1129 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.0565 | 0.0565 |
Onchocerca volvulus | 0.0121 | 0.0565 | 0.0565 | |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0449 | 0.5363 | 1 |
Echinococcus granulosus | cathepsin b | 0.016 | 0.1129 | 0.1129 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0449 | 0.5363 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0121 | 0.0565 | 0.0565 |
Plasmodium falciparum | metacaspase-like protein | 0.0303 | 0.3226 | 0.5546 |
Onchocerca volvulus | 0.0121 | 0.0565 | 0.0565 | |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0303 | 0.3226 | 0.6016 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0449 | 0.5363 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0565 | 0.1054 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.0565 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0766 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0303 | 0.3226 | 0.6016 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0766 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.0565 | 0.0565 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0565 | 0.1054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 0.1129 | 0.1129 |
Echinococcus granulosus | caspase 8 | 0.0303 | 0.3226 | 0.3226 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0449 | 0.5363 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0587 | 0.7381 | 0.7381 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0121 | 0.0565 | 0.0565 |
Echinococcus multilocularis | cathepsin b | 0.016 | 0.1129 | 0.0597 |
Plasmodium falciparum | metacaspase 1 | 0.0303 | 0.3226 | 0.5546 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trypanosoma brucei | metacaspase MCA3 | 0.0303 | 0.3226 | 0.5546 |
Onchocerca volvulus | Cathepsin L homolog | 0.0121 | 0.0565 | 0.0565 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0449 | 0.5363 | 0.5363 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Leishmania major | metacaspase, putative | 0.0303 | 0.3226 | 0.5546 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.3226 | 0.3226 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Echinococcus granulosus | proteasome prosome macropain | 0.0449 | 0.5363 | 0.5363 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0449 | 0.5363 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0449 | 0.5363 | 0.5085 |
Onchocerca volvulus | 0.0121 | 0.0565 | 0.0565 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 0.1129 | 0.1129 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0766 | 1 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0303 | 0.3226 | 0.5546 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1129 | 0.1129 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0449 | 0.5363 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0449 | 0.5363 | 0.5363 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.0565 | 0.1054 |
Onchocerca volvulus | 0.0121 | 0.0565 | 0.0565 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.0565 | 0.0565 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0449 | 0.5363 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0303 | 0.3226 | 0.5546 |
Echinococcus multilocularis | caspase 3 | 0.0284 | 0.295 | 0.2527 |
Onchocerca volvulus | 0.0121 | 0.0565 | 0.0565 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0238 | 0.2271 | 0.1807 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0238 | 0.2271 | 0.2271 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Loa Loa (eye worm) | cysteine protease | 0.0121 | 0.0565 | 0.0565 |
Trypanosoma cruzi | metacaspase, putative | 0.0303 | 0.3226 | 0.6016 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0121 | 0.0565 | 0.0565 |
Schistosoma mansoni | hypothetical protein | 0.0322 | 0.351 | 0.351 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0303 | 0.3226 | 0.6016 |
Trypanosoma cruzi | metacaspase, putative | 0.0303 | 0.3226 | 0.6016 |
Echinococcus granulosus | caspase | 0.0587 | 0.7381 | 0.7381 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0449 | 0.5363 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0303 | 0.3226 | 0.6016 |
Echinococcus granulosus | caspase 2 | 0.0766 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0303 | 0.3226 | 0.6016 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.016 | 0.1129 | 0.2105 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0449 | 0.5363 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0303 | 0.3226 | 0.6016 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0121 | 0.0565 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.2271 | 0.2271 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.0565 | 0.1054 |
Trypanosoma brucei | metacaspase MCA2 | 0.0303 | 0.3226 | 0.5546 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0322 | 0.351 | 0.351 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0322 | 0.351 | 0.3121 |
Onchocerca volvulus | 0.0121 | 0.0565 | 0.0565 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -20 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM | ChEMBL. | 12593659 |
Change (functional) | = -20 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM | ChEMBL. | 12593659 |
Change (functional) | = -17 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM | ChEMBL. | 12593659 |
Change (functional) | = -17 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM | ChEMBL. | 12593659 |
Change (functional) | = -10 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM | ChEMBL. | 12593659 |
Change (functional) | = -10 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM | ChEMBL. | 12593659 |
Change (functional) | = -10 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM | ChEMBL. | 12593659 |
Change (functional) | = -10 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM | ChEMBL. | 12593659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.