TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 271.318 | Formula: C14H17N5O
H donors: 2 H acceptors: 4 LogP: 1.46 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(CNC(=O)Nc1ccnc(n1)c1ccncc1)C
InChi: 1S/C14H17N5O/c1-10(2)9-17-14(20)19-12-5-8-16-13(18-12)11-3-6-15-7-4-11/h3-8,10H,9H2,1-2H3,(H2,16,17,18,19,20)
InChiKey: NCYXRZVDUWADJS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0595	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0106	0.0094
Brugia malayi	G-protein coupled receptor	0.0595	1	1
Brugia malayi	GnHR receptor homolog	0.0595	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0595	1	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0886	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0106	0.0094
Echinococcus granulosus	neuropeptide Y receptor	0.0595	1	1
Echinococcus granulosus	fmrfamide receptor	0.0595	1	1
Brugia malayi	ecdysteroid receptor	0.0011	0.0106	0.0094
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0042	0.5
Schistosoma mansoni	nuclear receptor	0.0005	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Brugia malayi	nuclear receptor RXR	0.0006	0.0022	0.001
Onchocerca volvulus		0.0595	1	1
Schistosoma mansoni	biogenic amine receptor	0.0595	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0595	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0595	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	opsin-like receptor	0.0595	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0595	1	1
Onchocerca volvulus		0.0418	0.701	0.7007
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	myosin xvIII	0.0595	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0595	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0595	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Echinococcus granulosus	G protein coupled receptor 139	0.0595	1	1
Echinococcus multilocularis	dnaJ subfamily B	0.0426	0.7135	0.7132
Schistosoma mansoni	sodium-bile acid cotransporter	0.0249	0.4138	0.4138
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0106	0.0106
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0106	0.0094
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0595	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0595	1	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0022	0.001
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0042	0.5
Schistosoma mansoni	hypothetical protein	0.0595	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0053	0.0042
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0106	0.0094
Brugia malayi	Sodium Bile acid symporter family protein	0.0418	0.701	0.7007
Onchocerca volvulus		0.0595	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0595	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0106	0.0094
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0022	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0106	0.0094
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0595	1	1
Echinococcus multilocularis	sex peptide receptor	0.0595	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0595	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	adenoreceptor	0.0595	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0595	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0106	0.0094
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0106	0.0094
Schistosoma mansoni	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Schistosoma mansoni	amine GPCR	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Brugia malayi	sulfakinin receptor protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0595	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0106	0.0094
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0106	0.0094
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0106	0.0094
Schistosoma mansoni	amine GPCR	0.0595	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0595	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus granulosus	allatostatin A receptor	0.0595	1	1
Brugia malayi	nuclear hormone receptor	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0106	0.0094
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0053	0.0042
Schistosoma mansoni	histamine h1 receptor	0.0595	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0595	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0595	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0595	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0106	0.0094
Onchocerca volvulus		0.0595	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0595	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0595	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0022	0.001
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0022	0.001
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0595	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0595	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0106	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Brugia malayi	steroid hormone receptor	0.0011	0.0106	0.0094
Brugia malayi	G protein-coupled receptor	0.0595	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Brugia malayi	hypothetical protein	0.0006	0.0022	0.001
Echinococcus multilocularis	serotonin receptor	0.0595	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0106	0.0094
Brugia malayi	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.001
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0106	0.0094
Schistosoma mansoni	neuropeptide receptor	0.0595	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0042	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0595	1	1
Echinococcus multilocularis	serotonin receptor	0.0595	1	1
Brugia malayi	hypothetical protein	0.0595	1	1
Schistosoma mansoni	biogenic amine receptor	0.0595	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.0426	0.7135	0.7135
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0106	0.0094
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0106	0.0106
Schistosoma mansoni	sodium-bile acid cotransporter related	0.017	0.2799	0.2799
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0595	1	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0011	0.0011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Schistosoma mansoni	neuropeptide receptor	0.0595	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	neuropeptide receptor	0.0595	1	1
Brugia malayi	hypothetical protein	0.0595	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0595	1	1
Schistosoma mansoni	amine GPCR	0.0595	1	1
Brugia malayi	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0595	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0106	0.0094
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0106	0.0094
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0073
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0595	1	1
Brugia malayi	ORL1-like opioid receptor	0.0595	1	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0084	0.0073
Schistosoma mansoni	biogenic amine receptor	0.0595	1	1
Brugia malayi	hypothetical protein	0.0595	1	1
Brugia malayi	Serotonin receptor	0.0595	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0595	1	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0082	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0106	0.0106
Echinococcus granulosus	sex peptide receptor	0.0595	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0595	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0106	0.0094
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0106	0.0106
Trichomonas vaginalis	helicase, putative	0.0007	0.0042	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0595	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0595	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0595	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0106	0.0094
Brugia malayi	Dopamine receptor protein 2	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	cpg binding protein	0.0032	0.0462	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus granulosus	neuropeptide receptor A26	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.001
Schistosoma mansoni	zinc finger protein	0.0005	0.0011	0.0011
Loa Loa (eye worm)	melatonin receptor type 1A	0.0595	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0595	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0106	0.0106
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Echinococcus granulosus	neuropeptide receptor	0.0595	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0595	1	1
Brugia malayi	neuropeptide F receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	cpg binding protein	0.003	0.0433	0.0433
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0595	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0595	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0106	0.0094
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0106	0.0094
Loa Loa (eye worm)	TYRA-2 protein	0.0595	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0595	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0595	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0595	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Onchocerca volvulus		0.003	0.0433	0.0423
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0433	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0106	0.0094
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0595	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0022	0.001
Brugia malayi	RE15519p	0.0595	1	1
Brugia malayi	hypothetical protein	0.0595	1	1
Schistosoma mansoni	neuropeptide receptor	0.0595	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0106	0.0094
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0106	0.0106
Brugia malayi	hypothetical protein	0.0595	1	1
Echinococcus granulosus	serotonin receptor	0.0595	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Echinococcus multilocularis	neuropeptide receptor	0.0595	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0595	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0595	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1001	0.1001
Echinococcus granulosus	g protein coupled receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0106	0.0094
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0595	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0595	1	1
Brugia malayi	Dopamine receptor	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0106	0.0094
Echinococcus multilocularis	sodium bile acid cotransporter	0.0418	0.701	0.7007
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0106	0.0094
Brugia malayi	hypothetical protein	0.0006	0.0022	0.001
Echinococcus granulosus	neuropeptide s receptor	0.0595	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0022	0.0022
Echinococcus multilocularis	dro:myosuppressin receptor	0.0595	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0106	0.0094
Schistosoma mansoni	hypothetical protein	0.0595	1	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0011	0.0011
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0053	0.0053
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0042	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0595	1	1
Schistosoma mansoni	amine GPCR	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.001
Echinococcus granulosus	orexin receptor type 2	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0595	1	1
Echinococcus granulosus	sodium bile acid cotransporter	0.0418	0.701	0.7007
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0053	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Echinococcus granulosus	g protein coupled receptor	0.0595	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0595	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0595	1	1
Echinococcus granulosus	hypothetical protein	0.0595	1	1
Schistosoma mansoni	opsin-like receptor	0.0595	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0595	1	1
Echinococcus multilocularis	sodium bile acid cotransporter	0.0418	0.701	0.7007
Onchocerca volvulus		0.0595	1	1
Echinococcus granulosus	sodium bile acid cotransporter	0.0418	0.701	0.7007
Echinococcus multilocularis	sodium bile acid cotransporter	0.0418	0.701	0.7007
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Brugia malayi	Serotonin receptor	0.0595	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0106	0.0106
Brugia malayi	larval opioid receptor	0.0595	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0595	1	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0053	0.0042
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0595	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0106	0.0094
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0106	0.0094
Schistosoma mansoni	amine GPCR	0.0595	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0595	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0595	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0106	0.0094
Schistosoma mansoni	cpg binding protein	0.0032	0.0462	0.0462
Brugia malayi	Melatonin receptor type 1A	0.0595	1	1
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0106	0.0094
Schistosoma mansoni	opsin-like receptor	0.0595	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0595	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0022	0.001
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0595	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0595	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0106	0.0094
Echinococcus granulosus	7TM GPCR rhodopsin	0.0595	1	1
Brugia malayi	G-protein coupled receptor	0.0595	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0106	0.0094
Onchocerca volvulus		0.0595	1	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0595	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0595	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0595	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0595	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0595	1	1
Brugia malayi	hypothetical protein	0.0595	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0595	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0595	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0595	1	1
Echinococcus granulosus	sodium bile acid cotransporter	0.0418	0.701	0.7007
Loa Loa (eye worm)	G-protein coupled receptor	0.0595	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0106	0.0106
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0595	1	1
Brugia malayi	CXXC zinc finger family protein	0.003	0.0433	0.0423
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0418	0.701	0.701
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0106	0.0094
Schistosoma mansoni	coup transcription factor	0.0011	0.0106	0.0106
Echinococcus granulosus	tm gpcr rhodopsin	0.0595	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0011	0.0011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0106	0.0094
Echinococcus multilocularis	neuropeptide receptor A26	0.0595	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0595	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0595	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0011	0.0011
Echinococcus multilocularis	g-protein coupled receptor	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0106	0.0094
Echinococcus multilocularis	neuropeptides capa receptor	0.0595	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0106	0.0094
Brugia malayi	AKH receptor	0.0595	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0106	0.0094
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0073
Schistosoma mansoni	neuropeptide F-like receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0595	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0042	0.5
Echinococcus granulosus	neuropeptide receptor	0.0595	1	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0042	0.5
Onchocerca volvulus		0.0595	1	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0011	0.0011
Echinococcus multilocularis	somatostatin receptor	0.0595	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0595	1	1
Brugia malayi	putative neuropeptide receptor	0.0595	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0595	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0042	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0042	0.5
Echinococcus granulosus	g protein coupled receptor	0.0595	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0011	0.0106	0.0094
Brugia malayi	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.001
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0106	0.0106
Schistosoma mansoni	nuclear receptor	0.0005	0.0011	0.0011
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0595	1	1
Brugia malayi	neuropeptide F receptor	0.0595	1	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0462	0.0451
Echinococcus granulosus	rhodopsin orphan GPCR	0.0595	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0595	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0418	0.701	0.7007
Echinococcus granulosus	somatostatin receptor	0.0595	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0042	0.5
Brugia malayi	Dopamine receptor protein 1	0.0595	1	1
Schistosoma mansoni	hypothetical protein	0.0595	1	1
Onchocerca volvulus		0.0595	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0595	1	1
Echinococcus granulosus	dnaJ subfamily B	0.0426	0.7135	0.7132
Schistosoma mansoni	cpg binding protein	0.0032	0.0462	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0022	0.001
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0106	0.0106
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0595	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
PCA shift (functional)	= 2.2	Antiallergic activity against IgE-mediated passive cutaneous anaphylaxis (PCA) in rats	ChEMBL.	6180166

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 288628