Detailed information for compound 288693

Basic information

Technical information
  • TDR Targets ID: 288693
  • Name: 4-[3-[[4-(dimethylamino)benzoyl]amino]-4-[(4- methoxyphenyl)carbamoyl]anilino]-4-oxobutanoi c acid
  • MW: 504.534 | Formula: C27H28N4O6
  • H donors: 4 H acceptors: 5 LogP: 2.85 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)NC(=O)c1ccc(cc1NC(=O)c1ccc(cc1)N(C)C)NC(=O)CCC(=O)O
  • InChi: 1S/C27H28N4O6/c1-31(2)20-9-4-17(5-10-20)26(35)30-23-16-19(28-24(32)14-15-25(33)34)8-13-22(23)27(36)29-18-6-11-21(37-3)12-7-18/h4-13,16H,14-15H2,1-3H3,(H,28,32)(H,29,36)(H,30,35)(H,33,34)
  • InChiKey: ACRASRSHYKPQFT-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-[3-[[4-(dimethylamino)benzoyl]amino]-4-[(4-methoxyphenyl)carbamoyl]anilino]-4-oxo-butanoic acid
  • 4-[3-[[(4-dimethylaminophenyl)-oxomethyl]amino]-4-[(4-methoxyanilino)-oxomethyl]anilino]-4-oxobutanoic acid
  • 4-[[3-[(4-dimethylaminophenyl)carbonylamino]-4-[(4-methoxyphenyl)carbamoyl]phenyl]amino]-4-oxo-butanoic acid
  • 4-[3-[[4-(dimethylamino)benzoyl]amino]-4-[(4-methoxyphenyl)carbamoyl]anilino]-4-keto-butyric acid
  • 4-[[3-[(4-dimethylaminobenzoyl)amino]-4-[(4-methoxyphenyl)carbamoyl]phenyl]amino]-4-oxobutanoic acid
  • 4-[[3-[(4-dimethylaminobenzoyl)amino]-4-[(4-methoxyphenyl)carbamoyl]phenyl]amino]-4-oxo-butanoic acid
  • 4-[[3-[[(4-dimethylaminophenyl)-oxomethyl]amino]-4-[[(4-methoxyphenyl)amino]-oxomethyl]phenyl]amino]-4-oxobutanoic acid
  • 4-[[3-[(4-dimethylaminobenzoyl)amino]-4-[(4-methoxyphenyl)carbamoyl]phenyl]amino]-4-keto-butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619
Echinococcus granulosus beta tubulin 0.0025 0.0739 0.0739
Entamoeba histolytica tubulin family protein 0.0025 0.0739 0.0739
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Plasmodium vivax proteasome subunit beta type-7, putative 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0023 0.0619 0.0619
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0023 0.0619 0.0619
Trypanosoma brucei beta tubulin 0.0025 0.0739 0.0739
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0023 0.0619 0.0619
Loa Loa (eye worm) BEN-1 protein 0.0025 0.0739 0.0739
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0739 0.0739
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0023 0.0619 0.0619
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0023 0.0619 0.0619
Brugia malayi Proteasome subunit alpha type 1 0.0023 0.0619 0.0619
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0166 1 1
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Brugia malayi Proteasome subunit alpha type 7-1 0.0023 0.0619 0.0619
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0023 0.0619 0.0619
Brugia malayi Tubulin beta-1 chain 0.0025 0.0739 0.0739
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0166 1 1
Schistosoma mansoni tubulin subunit beta 0.0025 0.0739 0.0739
Trypanosoma cruzi beta tubulin, putative 0.0025 0.0739 0.0739
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0025 0.0739 0.0739
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0023 0.0619 0.0619
Schistosoma mansoni tubulin subunit beta 0.0025 0.0739 0.0739
Trichomonas vaginalis tubulin epsilon chain, putative 0.0025 0.0739 0.0739
Plasmodium falciparum tubulin beta chain 0.0025 0.0739 0.0739
Plasmodium vivax proteasome subunit beta type-6, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0023 0.0619 0.0619
Giardia lamblia Proteasome subunit beta type 2 0.0074 0.3945 0.3945
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0023 0.0619 0.0619
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0166 1 1
Brugia malayi Proteasome A-type and B-type family protein 0.0023 0.0619 0.0619
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0023 0.0619 0.0619
Toxoplasma gondii peptidase, T1 family protein 0.0023 0.0619 0.0619
Echinococcus granulosus proteasome subunit alpha type 2 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0023 0.0619 0.0619
Trypanosoma brucei proteasome beta 7 subunit 0.0023 0.0619 0.0619
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0074 0.3945 0.3945
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0166 1 1
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0023 0.0619 0.5
Mycobacterium ulcerans proteasome PrcA 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0023 0.0619 0.0619
Giardia lamblia Beta tubulin 0.0025 0.0739 0.0739
Toxoplasma gondii beta tubulin 0.0025 0.0739 0.0739
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0739 0.0739
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0166 1 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Echinococcus multilocularis proteasome subunit beta type 6 0.0023 0.0619 0.0619
Loa Loa (eye worm) BEN-1 protein 0.0025 0.0739 0.0739
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0023 0.0619 0.0619
Onchocerca volvulus Notchless protein homolog 0.0023 0.0619 0.5
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0023 0.0619 0.0619
Echinococcus granulosus beta tubulin 0.0025 0.0739 0.0739
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0023 0.0619 0.0619
Giardia lamblia 20S proteasome alpha subunit 6 0.0023 0.0619 0.0619
Loa Loa (eye worm) tubulin beta-2A chain 0.0025 0.0739 0.0739
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0023 0.0619 0.0619
Loa Loa (eye worm) tubulin beta-1 chain 0.0025 0.0739 0.0739
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0023 0.0619 0.0619
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0023 0.0619 0.0619
Trypanosoma brucei beta tubulin 0.0025 0.0739 0.0739
Schistosoma mansoni tubulin subunit beta 0.0025 0.0739 0.0739
Plasmodium vivax proteasome subunit beta type-3, putative 0.0023 0.0619 0.0619
Trypanosoma brucei proteasome beta 6 subunit 0.0023 0.0619 0.0619
Loa Loa (eye worm) tubulin beta-4 chain 0.0025 0.0739 0.0739
Entamoeba histolytica tubulin family protein 0.0025 0.0739 0.0739
Loa Loa (eye worm) beta-tubulin 0.0025 0.0739 0.0739
Giardia lamblia Beta tubulin 0.0025 0.0739 0.0739
Brugia malayi Proteasome A-type and B-type family protein 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619
Trichomonas vaginalis tubulin epsilon chain, putative 0.0025 0.0739 0.0739
Toxoplasma gondii proteasome subunit 0.0023 0.0619 0.0619
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0023 0.0619 0.0619
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0166 1 1
Brugia malayi proteasome subunit alpha type 4 0.0023 0.0619 0.0619
Schistosoma mansoni tubulin subunit beta 0.0025 0.0739 0.0739
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619
Echinococcus multilocularis proteasome subunit alpha type 2 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0023 0.0619 0.0619
Brugia malayi proteasome subunit alpha type 3 0.0023 0.0619 0.0619
Trichomonas vaginalis tubulin beta chain, putative 0.0025 0.0739 0.0739
Toxoplasma gondii proteasome subunit beta type, putative 0.0166 1 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0166 1 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0074 0.3945 0.3945
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0074 0.3945 0.3945
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0023 0.0619 0.0619
Echinococcus granulosus proteasome subunit beta type 7 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0023 0.0619 0.0619
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome subunit beta type 1 0.0023 0.0619 0.0619
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0739 0.0739
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0739 0.0739
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0023 0.0619 0.0619
Brugia malayi proteasome subunit beta type 1 0.0023 0.0619 0.0619
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0074 0.3945 0.3945
Echinococcus multilocularis beta tubulin 0.0025 0.0739 0.0739
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Echinococcus multilocularis tubulin subunit beta 0.0025 0.0739 0.0739
Loa Loa (eye worm) proteasome subunit beta type 3 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0023 0.0619 0.0619
Brugia malayi proteasome subunit alpha type 1 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0023 0.0619 0.0619
Toxoplasma gondii beta-1 tubulin, putative 0.0025 0.0739 0.0739
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0023 0.0619 0.0619
Trichomonas vaginalis tubulin, putative 0.0025 0.0739 0.0739
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0023 0.0619 0.0619
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0023 0.0619 0.0619
Giardia lamblia 20S proteasome alpha subunit 2 0.0023 0.0619 0.0619
Brugia malayi 20S proteasome alpha5 subunit 0.0023 0.0619 0.0619
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0023 0.0619 0.0619
Trichomonas vaginalis tubulin alpha chain, putative 0.0025 0.0739 0.0739
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0023 0.0619 0.0619
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0739 0.0739
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome subunit beta type 2 0.0074 0.3945 0.3945
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0023 0.0619 0.0619
Echinococcus granulosus tubulin subunit beta 0.0025 0.0739 0.0739
Toxoplasma gondii proteasome subunit alpha type, putative 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0023 0.0619 0.0619
Leishmania major proteasome beta 5 subunit, putative 0.0166 1 1
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Echinococcus granulosus subfamily T1A non peptidase ue 0.0023 0.0619 0.0619
Plasmodium vivax tubulin beta chain, putative 0.0025 0.0739 0.0739
Brugia malayi beta-tubulin, identical 0.0025 0.0739 0.0739
Echinococcus granulosus proteasome subunit beta t family 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0023 0.0619 0.0619
Schistosoma mansoni tubulin subunit beta 0.0025 0.0739 0.0739
Mycobacterium ulcerans proteasome PrcB 0.0166 1 1
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0023 0.0619 0.0619
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0739 0.0739
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0023 0.0619 0.0619
Trichomonas vaginalis tubulin gamma chain, putative 0.0025 0.0739 0.0739
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0023 0.0619 0.0619
Echinococcus granulosus proteasome subunit beta type 6 0.0023 0.0619 0.0619
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0023 0.0619 0.0619
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0023 0.0619 0.0619
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0074 0.3945 0.3945
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0023 0.0619 0.0619
Toxoplasma gondii proteasome subunit alpha1, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0739 0.0739
Echinococcus granulosus Proteasome subunit alpha beta 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0023 0.0619 0.0619
Brugia malayi proteasome subunit beta type 3 0.0023 0.0619 0.0619
Echinococcus granulosus proteasome prosome macropain 0.0166 1 1
Trypanosoma brucei beta tubulin 0.0025 0.0739 0.0739
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0023 0.0619 0.0619
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0023 0.0619 0.0619
Echinococcus granulosus tubulin beta 4A class IVa 0.0025 0.0739 0.0739
Echinococcus granulosus tubulin beta 1 chain 0.0025 0.0739 0.0739
Plasmodium vivax proteasome subunit beta type-1, putative 0.0023 0.0619 0.0619
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0166 1 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0074 0.3945 0.3945
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0023 0.0619 0.0619
Brugia malayi proteasome subunit alpha type 2 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0166 1 1
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0023 0.0619 0.0619
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0023 0.0619 0.0619
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0074 0.3945 0.3945
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0023 0.0619 0.0619
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0023 0.0619 0.0619
Giardia lamblia Proteasome subunit beta type 3 0.0023 0.0619 0.0619
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0023 0.0619 0.0619
Brugia malayi proteasome subunit alpha type 6 0.0023 0.0619 0.0619
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi 20S proteasome subunit 0.0074 0.3945 0.3945
Echinococcus multilocularis tubulin beta 1 chain 0.0025 0.0739 0.0739
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0023 0.0619 0.0619
Brugia malayi proteasome subunit beta type 2 0.0074 0.3945 0.3945
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0023 0.0619 0.0619
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis proteasome subunit beta type 7 0.0023 0.0619 0.0619
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0739 0.0739
Giardia lamblia Beta tubulin 0.0025 0.0739 0.0739
Plasmodium vivax proteasome subunit beta type-4, putative 0.0023 0.0619 0.0619
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0023 0.0619 0.0619
Giardia lamblia 20S proteasome alpha subunit 5 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0023 0.0619 0.0619
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0074 0.3945 0.3945
Echinococcus granulosus proteasome subunit alpha type 6 0.0023 0.0619 0.0619
Plasmodium falciparum proteasome subunit beta type-4 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0074 0.3945 0.3945
Echinococcus granulosus Proteasome subunit alpha type 7 0.0023 0.0619 0.0619
Giardia lamblia 20S proteasome alpha subunit 4 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Echinococcus multilocularis proteasome subunit alpha type 6 0.0023 0.0619 0.0619
Echinococcus multilocularis proteasome (prosome, macropain) 0.0166 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619
Giardia lamblia 20S proteasome alpha subunit 1 0.0023 0.0619 0.0619
Schistosoma mansoni tubulin subunit beta 0.0025 0.0739 0.0739
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0023 0.0619 0.0619
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0023 0.0619 0.0619
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0023 0.0619 0.0619
Giardia lamblia 20S proteasome alpha subunit 7 0.0023 0.0619 0.0619
Giardia lamblia Proteasome subunit beta type 1 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Toxoplasma gondii beta-tubulin, putative 0.0025 0.0739 0.0739
Toxoplasma gondii heat shock protein hslv, putative 0.0023 0.0619 0.0619
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0023 0.0619 0.0619
Giardia lamblia 20S proteasome alpha subunit 3 0.0023 0.0619 0.0619
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0023 0.0619 0.0619
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0074 0.3945 0.3945
Trypanosoma brucei proteasome alpha 7 subunit 0.0023 0.0619 0.0619
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0023 0.0619 0.0619
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0023 0.0619 0.0619
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0074 0.3945 0.3945
Loa Loa (eye worm) tubulin beta chain 0.0025 0.0739 0.0739
Toxoplasma gondii proteasome beta subunit 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619
Leishmania major beta tubulin 0.0025 0.0739 0.0127
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0023 0.0619 0.0619
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0739 0.0739
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0023 0.0619 0.0619
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0023 0.0619 0.0619
Plasmodium falciparum proteasome subunit beta type-5 0.0166 1 1
Brugia malayi Proteasome A-type and B-type family protein 0.0023 0.0619 0.0619
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0739 0.0739
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0023 0.0619 0.0619
Loa Loa (eye worm) PAS-3 protein 0.0023 0.0619 0.0619
Trypanosoma brucei beta tubulin 0.0025 0.0739 0.0739
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0023 0.0619 0.0619
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0166 1 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0023 0.0619 0.0619
Leishmania major proteasome beta 2 subunit, putative 0.0074 0.3945 0.3546
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0023 0.0619 0.0619
Plasmodium vivax proteasome subunit beta type-5, putative 0.0166 1 1
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0074 0.3945 0.3945
Echinococcus multilocularis beta tubulin 0.0025 0.0739 0.0739
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0023 0.0619 0.0619
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0023 0.0619 0.0619

Activities

Activity type Activity value Assay description Source Reference
K ass (binding) = 9600000 l M-1 Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. ChEMBL. 10715154
K ass (binding) = 9600000 l M-1 Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. ChEMBL. 10715154

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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