Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0123 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0006 | 0.0218 | 0.1759 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0007 | 0.0277 | 0.2094 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0008 | 0.0356 | 0.0983 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0006 | 0.0218 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6598 | 0.6591 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0017 | 0.1149 | 0.9232 |
Onchocerca volvulus | 0.0006 | 0.0218 | 0.0198 | |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0006 | 0.0218 | 0.0578 |
Entamoeba histolytica | inositol polyphosphate-5-phosphatase, putative | 0.0004 | 0.0021 | 0.017 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0017 | 0.1149 | 0.9232 |
Brugia malayi | hypothetical protein | 0.0011 | 0.064 | 0.062 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0006 | 0.0218 | 0.0578 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0004 | 0.0073 | 0.0426 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3434 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3434 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.1242 | 0.3578 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0637 | 0.5045 |
Loa Loa (eye worm) | TAR-binding protein | 0.0043 | 0.3322 | 0.3308 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0007 | 0.0277 | 0.2094 |
Leishmania major | hypothetical protein, conserved | 0.0017 | 0.1149 | 0.9232 |
Brugia malayi | RasGEF domain containing protein | 0.0004 | 0.0073 | 0.0052 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0006 | 0.0218 | 0.0578 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0004 | 0.0073 | 0.0052 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0017 | 0.1149 | 0.9232 |
Echinococcus multilocularis | ras GTP exchange factor | 0.0004 | 0.0073 | 0.0152 |
Schistosoma mansoni | tar DNA-binding protein | 0.0043 | 0.3322 | 0.9672 |
Schistosoma mansoni | tar DNA-binding protein | 0.0043 | 0.3322 | 0.9672 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Schistosoma mansoni | DNA helicase recq1 | 0.0007 | 0.0277 | 0.0749 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.3434 | 0.342 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Echinococcus multilocularis | Protein son of sevenless | 0.0004 | 0.0073 | 0.0152 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.1242 | 1 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Brugia malayi | RNA binding protein | 0.0043 | 0.3322 | 0.3308 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0004 | 0.0073 | 0.0152 |
Brugia malayi | RasGEF domain containing protein | 0.0004 | 0.0073 | 0.0052 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0013 | 0.0792 | 0.226 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.1149 | 0.113 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0007 | 0.0277 | 0.0749 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0009 | 0.0443 | 0.3455 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0277 | 0.2229 |
Echinococcus granulosus | rap guanine nucleotide exchange factor 1 | 0.0004 | 0.0073 | 0.0152 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0277 | 0.2229 |
Onchocerca volvulus | 0.0004 | 0.0073 | 0.0052 | |
Schistosoma mansoni | dep domain containing protein | 0.0006 | 0.0218 | 0.0578 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0043 | 0.3322 | 0.3308 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0996 | 0.2855 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0017 | 0.1149 | 0.9232 |
Brugia malayi | TAR-binding protein | 0.0043 | 0.3322 | 0.3308 |
Echinococcus granulosus | Protein son of sevenless | 0.0004 | 0.0073 | 0.0152 |
Schistosoma mansoni | ras GTP exchange factor | 0.0004 | 0.0073 | 0.0152 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0004 | 0.0073 | 0.0052 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0006 | 0.0218 | 0.0578 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0996 | 0.2855 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0218 | 0.0198 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0996 | 0.2855 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0007 | 0.0277 | 0.0749 |
Echinococcus multilocularis | bloom syndrome protein | 0.0016 | 0.108 | 0.3103 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1242 | 1 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0426 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0006 | 0.0218 | 0.0578 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0004 | 0.0073 | 0.0052 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.1242 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0008 | 0.0356 | 0.0983 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0006 | 0.0218 | 0.0578 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0016 | 0.108 | 0.1061 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0996 | 0.2855 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0043 | 0.3322 | 0.3308 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3434 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0006 | 0.0218 | 0.0198 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.3768 | 0.3755 |
Echinococcus granulosus | rap guanine nucleotide exchange factor 6 | 0.0004 | 0.0073 | 0.0152 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.1242 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0006 | 0.0218 | 0.0198 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0006 | 0.0218 | 0.0198 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3434 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.1242 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0014 | 0.0914 | 0.7312 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1242 | 0.3578 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0017 | 0.1149 | 0.9245 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0006 | 0.0218 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0996 | 0.0977 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Trypanosoma cruzi | hypothetical protein | 0.0004 | 0.0073 | 0.0426 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0004 | 0.0073 | 0.0152 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0356 | 0.0983 |
Brugia malayi | RasGEF domain containing protein | 0.0004 | 0.0073 | 0.0052 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2485 | 0.7219 |
Echinococcus granulosus | son of sevenless 1 | 0.0004 | 0.0073 | 0.0152 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0004 | 0.0073 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3768 | 0.3755 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0073 | 0.0052 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0626 | 0.504 |
Schistosoma mansoni | dishevelled | 0.0006 | 0.0218 | 0.0578 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0007 | 0.0277 | 0.0256 |
Entamoeba histolytica | recQ family helicase, putative | 0.0009 | 0.0443 | 0.3566 |
Schistosoma mansoni | regulator of G protein signaling | 0.0006 | 0.0218 | 0.0578 |
Brugia malayi | DIX domain containing protein | 0.0006 | 0.0218 | 0.0198 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1242 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0009 | 0.0443 | 0.3455 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase domain containing protein | 0.0004 | 0.0021 | 0.017 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.1242 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0006 | 0.0218 | 0.0198 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.1242 | 0.1224 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0073 | 0.0589 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0996 | 0.0977 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0006 | 0.0218 | 0.0578 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0017 | 0.1149 | 0.9232 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0004 | 0.0073 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0996 | 0.2855 |
Loa Loa (eye worm) | RNA binding protein | 0.0043 | 0.3322 | 0.3308 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0007 | 0.0277 | 0.0749 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0006 | 0.0218 | 0.0198 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3434 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.1242 | 0.1224 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0004 | 0.0073 | 0.0426 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1242 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0009 | 0.0443 | 0.3455 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1242 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.3768 | 0.3755 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0006 | 0.0218 | 0.0578 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.2485 | 0.2469 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0218 | 0.0198 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0996 | 0.2855 |
Echinococcus granulosus | tar DNA binding protein | 0.0043 | 0.3322 | 0.9672 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0016 | 0.108 | 0.8672 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0277 | 0.0256 |
Echinococcus multilocularis | tar DNA binding protein | 0.0043 | 0.3322 | 0.9672 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0004 | 0.0073 | 0.0426 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.3434 | 0.342 |
Echinococcus granulosus | ras GTP exchange factor | 0.0004 | 0.0073 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0073 | 0.0052 |
Brugia malayi | N-terminal motif family protein | 0.0004 | 0.0073 | 0.0052 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.3768 | 0.3755 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0996 | 0.2855 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0996 | 0.2855 |
Brugia malayi | N-terminal motif family protein | 0.0004 | 0.0073 | 0.0052 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0996 | 0.0977 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0004 | 0.0073 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2485 | 0.2469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0043 | 0.3322 | 0.9672 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0218 | 0.0198 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1242 | 0.3578 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0996 | 0.0977 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Echinococcus multilocularis | rap guanine nucleotide exchange factor 6 | 0.0004 | 0.0073 | 0.0152 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0016 | 0.108 | 0.8672 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0017 | 0.1149 | 0.9232 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0007 | 0.0277 | 0.0749 |
Schistosoma mansoni | dishevelled | 0.0006 | 0.0218 | 0.0578 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0021 | 0.017 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.1242 | 1 |
Echinococcus multilocularis | son of sevenless 1 | 0.0004 | 0.0073 | 0.0152 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3434 | 1 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0004 | 0.0073 | 0.0426 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase domain containing protein | 0.0004 | 0.0021 | 0.017 |
Loa Loa (eye worm) | RecQ helicase | 0.0016 | 0.108 | 0.1061 |
Entamoeba histolytica | inositol polyphosphate 5-phosphatase, putative | 0.0004 | 0.0021 | 0.017 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.1242 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.1242 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0009 | 0.0443 | 0.3455 |
Schistosoma mansoni | tar DNA-binding protein | 0.0043 | 0.3322 | 0.9672 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0218 | 0.0198 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0277 | 0.0256 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0996 | 0.2855 |
Trypanosoma cruzi | hypothetical protein | 0.0004 | 0.0073 | 0.0426 |
Echinococcus granulosus | bloom syndrome protein | 0.0016 | 0.108 | 0.3103 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.1242 | 0.3578 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1242 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0996 | 0.2855 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0218 | 0.0198 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0006 | 0.0218 | 0.0578 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1242 | 1 |
Schistosoma mansoni | camp-dependent rap1 guanine-nucleotide exchange factor | 0.0004 | 0.0055 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0277 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1149 | 0.113 |
Schistosoma mansoni | DNA helicase recq5 | 0.0007 | 0.0277 | 0.0749 |
Schistosoma mansoni | tar DNA-binding protein | 0.0043 | 0.3322 | 0.9672 |
Entamoeba histolytica | sphingomyelinase C precursor, putative | 0.0004 | 0.0021 | 0.017 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0004 | 0.0073 | 0.0589 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0006 | 0.0218 | 0.0578 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0006 | 0.0218 | 0.0578 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.1242 | 1 |
Echinococcus multilocularis | rap guanine nucleotide exchange factor 1 | 0.0004 | 0.0073 | 0.0152 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3434 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease in SBP (functional) | NA 0 % | Percentage fall in systolic blood pressure after 1 hr at 25 mg/kg given perorally | ChEMBL. | 6133954 |
Decrease in SBP (functional) | NA 0 % | Percentage fall in systolic blood pressure after 3 hr at 25 mg/kg given perorally | ChEMBL. | 6133954 |
Decrease in SBP (functional) | = 16 % | Percentage fall in systolic blood pressure after 4 hr at 25 mg/kg given perorally | ChEMBL. | 6133954 |
Decrease in SBP (functional) | = 25 % | Percentage fall in systolic blood pressure after 2 hr at 25 mg/kg given perorally | ChEMBL. | 6133954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.