Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Toxoplasma gondii | MAPEG family protein | 0.0548 | 0.8039 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0483 | 0.7036 | 0.5 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0548 | 0.8039 | 0.788 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0675 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0324 | 0.4566 | 0.4127 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0483 | 0.7036 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.0077 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0675 | 1 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0077 | 0.0747 | 0.5 |
Loa Loa (eye worm) | doublecortin family protein | 0.0077 | 0.0747 | 0.0747 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0675 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0483 | 0.7036 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0463 | 0.6727 | 0.6462 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0483 | 0.7036 | 0.5 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0548 | 0.8039 | 0.788 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0463 | 0.6727 | 0.6462 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0548 | 0.8039 | 0.788 |
Brugia malayi | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Onchocerca volvulus | 0.0077 | 0.0747 | 0.5 | |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.0483 | 0.7036 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0077 | 0.0747 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0463 | 0.6727 | 0.6462 |
Onchocerca volvulus | 0.0077 | 0.0747 | 0.5 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0675 | 1 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0483 | 0.7036 | 0.5 |
Brugia malayi | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0548 | 0.8039 | 0.788 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
PCA shift (functional) | = 3 | Antiallergic activity against IgE-mediated passive cutaneous anaphylaxis (PCA) in rats | ChEMBL. | 6180166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.