Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast growth factor receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0095 | 0.1593 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1593 | 0.1593 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0095 | 0.1593 | 0.1593 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0165 | 0.2856 | 0.1502 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0095 | 0.1593 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0095 | 0.1593 | 0.1593 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0095 | 0.1593 | 0.1593 |
Onchocerca volvulus | 0.0095 | 0.1593 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0562 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0095 | 0.1593 | 0.5 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.016 | 0.277 | 0.277 |
Loa Loa (eye worm) | TK protein kinase | 0.0165 | 0.2856 | 0.2856 |
Echinococcus multilocularis | neuroligin | 0.0095 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | carboxylesterase | 0.0562 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0562 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0095 | 0.1593 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0562 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0095 | 0.1593 | 0.1593 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0095 | 0.1593 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0095 | 0.1593 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0095 | 0.1593 | 0.1593 |
Onchocerca volvulus | 0.0095 | 0.1593 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0095 | 0.1593 | 0.1593 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.016 | 0.277 | 0.277 |
Echinococcus granulosus | carboxylesterase 5A | 0.0562 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0095 | 0.1593 | 0.1593 |
Onchocerca volvulus | 0.0095 | 0.1593 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.016 | 0.277 | 0.277 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1593 | 0.1593 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0095 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1593 | 0.1593 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0095 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1593 | 0.1593 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.016 | 0.277 | 0.277 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1593 | 0.1593 |
Schistosoma mansoni | gliotactin | 0.0095 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0095 | 0.1593 | 0.1593 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0095 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | carboxylesterase | 0.0095 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1593 | 0.1593 |
Onchocerca volvulus | 0.0095 | 0.1593 | 1 | |
Onchocerca volvulus | 0.0095 | 0.1593 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0095 | 0.1593 | 0.1593 |
Echinococcus multilocularis | acetylcholinesterase | 0.0562 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0562 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0562 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0562 | 1 | 1 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.016 | 0.277 | 0.277 |
Schistosoma mansoni | acetylcholinesterase | 0.0095 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1593 | 0.1593 |
Echinococcus multilocularis | acetylcholinesterase | 0.0562 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0095 | 0.1593 | 0.1593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 71 nM | In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line | ChEMBL. | 15012985 |
IC50 (binding) | = 71 nM | In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line | ChEMBL. | 15012985 |
Metabolism (functional) | = 72 % | Percent of the compound remaining after incubation with rat liver microsomes for 10 min | ChEMBL. | 15012985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.