Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0134 | 0.2402 | 0.2402 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0205 | 0.7363 | 0.7264 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.011 | 0.0686 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.011 | 0.0686 | 0.0686 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.011 | 0.0686 | 0.0686 |
Echinococcus granulosus | acetylcholinesterase | 0.0242 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0242 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0242 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.011 | 0.0686 | 0.0686 |
Loa Loa (eye worm) | carboxylesterase | 0.0242 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0105 | 0.0364 | 0.0364 |
Echinococcus multilocularis | glutamate receptor 2 | 0.011 | 0.0686 | 0.0686 |
Echinococcus granulosus | glutamate receptor 2 | 0.011 | 0.0686 | 0.0686 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0242 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0105 | 0.0364 | 0.0364 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0105 | 0.0364 | 0.0364 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.011 | 0.0686 | 0.0686 |
Echinococcus granulosus | acetylcholinesterase | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.011 | 0.0686 | 0.0686 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.011 | 0.0686 | 0.0686 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.011 | 0.0686 | 0.0686 |
Echinococcus multilocularis | acetylcholinesterase | 0.0242 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0242 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0242 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0134 | 0.2402 | 0.2402 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | nM | Displacement of [3H]-prazosin from alpha-1 adrenergic receptor | ChEMBL. | 12617901 |
Ki (binding) | nM | Displacement of [3H]-pirenzepine M1 receptor | ChEMBL. | 12617901 |
Ki (binding) | 0 nM | Displacement of [3H]-prazosin from alpha-1 adrenergic receptor | ChEMBL. | 12617901 |
Ki (binding) | 0 nM | Displacement of [3H]-pirenzepine M1 receptor | ChEMBL. | 12617901 |
Ki (binding) | = 7500 nM | Binding affinity against NMDA receptor by displacement of [3H]-Ro-25-6981 | ChEMBL. | 12617901 |
Ki (binding) | = 7500 nM | Binding affinity against NMDA receptor by displacement of [3H]-Ro-25-6981 | ChEMBL. | 12617901 |
pKa | = 3 | Dissociation constant (pKa) | ChEMBL. | 12617901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.