Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aminopeptidase puromycin sensitive | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Peptidase family M1 containing protein | aminopeptidase puromycin sensitive | 919 aa | 834 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0122 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0054 | 0.0268 | 0.0122 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0149 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0424 | 0.3957 | 0.3957 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0149 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0484 | 0.4547 | 1 |
Brugia malayi | CHE-14 protein | 0.0424 | 0.3957 | 0.3866 |
Onchocerca volvulus | 0.0042 | 0.0148 | 0.5 | |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0054 | 0.0268 | 0.0149 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0424 | 0.3957 | 0.3883 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0424 | 0.3957 | 0.3866 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0054 | 0.0268 | 0.0268 |
Echinococcus multilocularis | protein dispatched 1 | 0.0424 | 0.3957 | 0.3883 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0042 | 0.0148 | 0.0148 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0424 | 0.3957 | 0.3866 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0424 | 0.3957 | 0.3883 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0424 | 0.3957 | 0.8621 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1031 | 1 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0042 | 0.0148 | 0.0028 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0424 | 0.3957 | 0.3866 |
Loa Loa (eye worm) | aminopeptidase N | 0.0054 | 0.0268 | 0.0268 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0054 | 0.0268 | 0.0268 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0122 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.3957 | 0.3957 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0149 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0484 | 0.4547 | 1 |
Schistosoma mansoni | patched 1 | 0.0424 | 0.3957 | 0.3957 |
Echinococcus multilocularis | protein patched | 0.0424 | 0.3957 | 0.3883 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0484 | 0.4547 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1031 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0149 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0122 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0484 | 0.4547 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0.0148 | 0.0148 |
Entamoeba histolytica | aminopeptidase, putative | 0.0054 | 0.0268 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0054 | 0.0268 | 0.0122 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1031 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0054 | 0.0268 | 0.0268 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0424 | 0.3957 | 0.3957 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0054 | 0.0268 | 0.0122 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1031 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0054 | 0.0268 | 0.0122 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1031 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1031 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1031 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1031 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1031 | 1 | 1 |
Onchocerca volvulus | 0.0042 | 0.0148 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.6 uM | Puromycin sensitive aminopeptidase inhibitory activity of the compound was determined by the use of L-Ala AMC with MOLT-4 | ChEMBL. | 12467622 |
IC50 (binding) | = 4.6 uM | Puromycin sensitive aminopeptidase inhibitory activity of the compound was determined by the use of L-Ala AMC with MOLT-4 | ChEMBL. | 12467622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.