Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.3811 | 0.3811 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0339 | 0.5738 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0339 | 0.5738 | 0.5 |
Onchocerca volvulus | 0.0104 | 0.0902 | 0.5 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0546 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0546 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0546 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.2964 | 0.2267 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.3811 | 0.3811 |
Schistosoma mansoni | dihydrofolate reductase | 0.0546 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0339 | 0.5738 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.0902 | 0.0902 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.0902 | 0.0902 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0546 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.2964 | 0.2267 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0546 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0339 | 0.5738 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0339 | 0.5738 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0546 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0546 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0339 | 0.5738 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0546 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC T (ADMET) | = 30 nM hr-1 | The Plasma area under the compound concentration -time curve was measured in rats after oral administration of 1 mg/kg dose | ChEMBL. | 10072681 |
B/P (ADMET) | = 0 | The Brain concentration of the compound compared to plasma concentration of the compound in rats after oral administration of 1 mg/kg dose | ChEMBL. | 10072681 |
cLogP (ADMET) | = 4.85 | The calculated logp value of the compound was measured in rats after oral administration of 1 mg/kg dose | ChEMBL. | 10072681 |
Cmax (ADMET) | = 19.9 nM | The Peak plasma concentration of the compound was measured in rats after oral administration of 1 mg/kg dose | ChEMBL. | 10072681 |
F (ADMET) | = 7 % | Oral bioavailability in rat (dose 1 mg/kg) | ChEMBL. | 10072681 |
Ki (binding) | = 8 nM | Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells | ChEMBL. | 10072681 |
Ki (binding) | = 8 nM | Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells | ChEMBL. | 10072681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.