Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5079 | 0.6814 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7417 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7417 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7417 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Brugia malayi | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 1 |
Brugia malayi | hypothetical protein | 0.0726 | 0.0884 | 0.0773 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Echinococcus granulosus | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7417 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7417 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Echinococcus granulosus | dihydrofolate reductase | 0.7417 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Schistosoma mansoni | dihydrofolate reductase | 0.7417 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7417 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0726 | 0.0884 | 0.1142 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0726 | 0.0884 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.7417 | 1 | 1 |
Onchocerca volvulus | 0.1526 | 0.1974 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1526 | 0.1974 | 0.1196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38.6 nM | Inhibition of solubilized, purified rat liver HMG-CoA reductase. | ChEMBL. | 3634830 |
Relative potency (binding) | = 14 | Inhibition of solubilized, purified rat liver HMG-CoA reductase, relative to compactin(100). | ChEMBL. | 3634830 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.