Detailed information for compound 289308

Basic information

Technical information
  • TDR Targets ID: 289308
  • Name: 3-(1a,2,3,7b-tetrahydro-1H-cyclopropa[a]napht halen-1-yl)pyridine
  • MW: 221.297 | Formula: C16H15N
  • H donors: 0 H acceptors: 1 LogP: 3.26 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cn1)C1C2C1CCc1c2cccc1
  • InChi: 1S/C16H15N/c1-2-6-13-11(4-1)7-8-14-15(16(13)14)12-5-3-9-17-10-12/h1-6,9-10,14-16H,7-8H2
  • InChiKey: QRKOWDMRFAGLGC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi cytochrome P450, putative cytochrome P450, family 19, subfamily A, polypeptide 1 503 aa 425 aa 18.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0262 0.1079 0.2217
Trichomonas vaginalis calmodulin, putative 0.0152 0.0597 0.1586
Brugia malayi calpain 7 0.0857 0.367 0.367
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0063
Leishmania major hypothetical protein, unknown function 0.035 0.1463 0.3016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Onchocerca volvulus Peroxidase homolog 0.0064 0.0218 0.0394
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0557 0.2364 0.2352
Leishmania major calcineurin B subunit, putative 0.0124 0.0479 0.0965
Echinococcus multilocularis EF hand domain containing family member A2 0.0124 0.0479 0.0479
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0092 0.0158
Echinococcus granulosus calcium uptake protein 1 0.0127 0.0491 0.0491
Echinococcus granulosus Mastin 0.0033 0.0082 0.0082
Onchocerca volvulus 0.0554 0.2348 0.4908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Onchocerca volvulus 0.0029 0.0064 0.0068
Schistosoma mansoni cytochrome P450 0.0018 0.0016 0.0016
Plasmodium falciparum serine repeat antigen 8 0.02 0.0808 0.2334
Brugia malayi Myosin regulatory light chain 1 0.0027 0.0055 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0179 0.0447
Schistosoma mansoni hypothetical protein 0.0126 0.0488 0.0488
Brugia malayi Cathepsin L-like precursor 0.0795 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0094
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.0079 0.0078
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0302 0.1254 0.124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0197 0.0197
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0022 0.0053
Onchocerca volvulus 0.0029 0.0064 0.0068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.02 0.0808 0.0807
Loa Loa (eye worm) beta-lactamase 0.0036 0.0095 0.0094
Trypanosoma cruzi kinesin, putative 0.0507 0.2144 0.2131
Loa Loa (eye worm) hypothetical protein 0.0047 0.0143 0.0143
Brugia malayi cathepsin F-like cysteine proteinase 0.0241 0.0987 0.0987
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.035 0.1463 0.3981
Echinococcus multilocularis peroxidasin 0.0064 0.0218 0.0218
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0124 0.0479 0.126
Brugia malayi Papain family cysteine protease containing protein 0.02 0.0808 0.0808
Trypanosoma cruzi cysteine peptidase, putative 0.0441 0.1858 0.1845
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0124 0.0479 0.1354
Brugia malayi beta-lactamase family protein 0.0036 0.0095 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0344 0.0344
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Onchocerca volvulus 0.0127 0.0491 0.0974
Onchocerca volvulus 0.0029 0.0064 0.0068
Onchocerca volvulus 0.0027 0.0055 0.005
Brugia malayi calpain family protein 1 0.1963 0.8484 0.8484
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0557 0.2364 0.4895
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0095 0.0201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.0808 0.0808
Trypanosoma cruzi prefoldin subunit, putative 0.0031 0.0071 0.0055
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Entamoeba histolytica cysteine protease, putative 0.02 0.0808 0.2328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Brugia malayi fibroinase precursor 0.02 0.0808 0.0808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Trichomonas vaginalis calcium binding proteins, putative 0.0124 0.0479 0.126
Echinococcus multilocularis cathepsin L cysteine protease 0.0795 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0071 0.0136
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0133 0.0117
Loa Loa (eye worm) papain family cysteine protease containing protein 0.02 0.0808 0.0807
Loa Loa (eye worm) hypothetical protein 0.0124 0.0479 0.0478
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0795 0.3398 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0082 0.0137
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0063
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.02 0.0808 0.22
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0097 0.0097
Trypanosoma brucei Component of motile flagella 41 0.0124 0.0479 0.0965
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0066
Onchocerca volvulus 0.0062 0.0208 0.0373
Echinococcus multilocularis lamin dm0 0.0053 0.017 0.017
Brugia malayi Papain family cysteine protease containing protein 0.02 0.0808 0.0808
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0197 0.0197
Echinococcus multilocularis cathepsin b 0.2311 1 1
Giardia lamblia Hypothetical protein 0.0127 0.0491 0.1295
Trichomonas vaginalis calmodulin-2, putative 0.0124 0.0479 0.126
Trypanosoma brucei Calpain-like protein CALP1.3 0.0557 0.2364 0.4895
Echinococcus multilocularis neurocalcin 0.0124 0.0479 0.0479
Leishmania major small myristoylated protein-1 0.0357 0.1492 0.3076
Schistosoma mansoni calmodulin-related 0.0027 0.0055 0.0055
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0669 0.2851 0.2839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0441 0.1858 0.506
Schistosoma mansoni calmodulin 0.0124 0.0479 0.0479
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0557 0.2364 0.2352
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.0479 0.0965
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.3528 0.3528
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0124 0.0479 0.0463
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0082 0.0181
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0082 0.067
Schistosoma mansoni cathepsin F (C01 family) 0.0554 0.2348 0.2348
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0137
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.02 0.0808 0.0808
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Echinococcus multilocularis calpain 0.0857 0.367 0.367
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Echinococcus granulosus cathepsin l1 0.0795 0.3398 0.3398
Mycobacterium leprae PROBABLE HYDROLASE 0.0026 0.0052 0.0365
Echinococcus granulosus calpain A 0.0857 0.367 0.367
Echinococcus multilocularis geminin 0.017 0.0678 0.0678
Brugia malayi Pre-SET motif family protein 0.0413 0.1735 0.1735
Entamoeba histolytica papain family cysteine protease domain containing protein 0.02 0.0808 0.2328
Onchocerca volvulus Cathepsin L homolog 0.0795 0.3398 0.7134
Brugia malayi Matrixin family protein 0.0022 0.0032 0.0032
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0545 0.0545
Brugia malayi programmed cell death protein 6 0.0124 0.0479 0.0479
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2311 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0095 0.0797
Trypanosoma brucei unspecified product 0.0019 0.0022 0.0011
Leishmania major calmodulin, putative 0.0124 0.0479 0.0965
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0207 0.0838 0.1714
Toxoplasma gondii EF hand domain-containing protein 0.0027 0.0055 0.0107
Echinococcus granulosus calpain 0.0857 0.367 0.367
Schistosoma mansoni hypothetical protein 0.0062 0.0208 0.0208
Loa Loa (eye worm) programmed cell death protein 6 0.0127 0.0491 0.0491
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.0218 0.0217
Plasmodium vivax unspecified product 0.0241 0.0987 0.269
Leishmania major prefoldin subunit, putative 0.0031 0.0071 0.0114
Trichomonas vaginalis calcium binding protein, putative 0.0152 0.0597 0.1586
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0546 0.2315 0.2302
Trichomonas vaginalis centrin, putative 0.0027 0.0055 0.0093
Brugia malayi cathepsin F-like cysteine proteinase 0.02 0.0808 0.0808
Entamoeba histolytica calpain family cysteine protease, putative 0.035 0.1463 0.4269
Toxoplasma gondii thioredoxin reductase 0.0096 0.0356 0.0934
Brugia malayi Cathepsin L-like precursor 0.0795 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0148 0.058 0.0579
Echinococcus multilocularis Mastin 0.0033 0.0082 0.0082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0563 0.2387 0.2375
Plasmodium falciparum plasmepsin I 0.0047 0.0143 0.0368
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0022 0.0011
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0857 0.367 0.366
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0082 0.8406
Leishmania major calpain protease-like protein 0.035 0.1463 0.3016
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.02 0.0808 0.22
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0032 0.0032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0794 0.3395 0.7044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.0808 0.2166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.0808 0.2166
Trypanosoma brucei calpain-like protein, putative 0.1119 0.4812 1
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0479 0.126
Echinococcus granulosus calumenin 0.0127 0.0491 0.0491
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Toxoplasma gondii calmodulin, putative 0.0027 0.0055 0.0107
Loa Loa (eye worm) hypothetical protein 0.1105 0.4751 0.4751
Giardia lamblia Dipeptidyl-peptidase I precursor 0.02 0.0808 0.2166
Entamoeba histolytica hypothetical protein 0.02 0.0808 0.2328
Entamoeba histolytica prefoldin subunit 6, putative 0.0031 0.0071 0.0146
Onchocerca volvulus 0.0033 0.0082 0.0108
Trichomonas vaginalis calcineurin B subunit, putative 0.0124 0.0479 0.126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Plasmodium falciparum serine repeat antigen 7 0.02 0.0808 0.2334
Plasmodium vivax calpain, putative 0.0857 0.367 1
Brugia malayi Papain family cysteine protease containing protein 0.0795 0.3398 0.3398
Echinococcus granulosus neuronal calcium sensor 0.0124 0.0479 0.0479
Leishmania major cathepsin L-like protease 0.0795 0.3398 0.7052
Plasmodium falciparum calpain 0.035 0.1463 0.4273
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0124 0.0479 0.1354
Treponema pallidum NADH oxidase 0.0033 0.0082 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0095 0.0797
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0092 0.0076
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0262 0.1079 0.2217
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.035 0.1463 0.3972
Schistosoma mansoni peroxidasin 0.0064 0.0218 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma cruzi small myristoylated protein 1-2 0.0357 0.1492 0.1478
Brugia malayi Animal haem peroxidase family protein 0.0064 0.0218 0.0218
Echinococcus multilocularis calumenin 0.0127 0.0491 0.0491
Loa Loa (eye worm) calpain 5 0.0507 0.2144 0.2144
Trypanosoma brucei cysteine peptidase, putative 0.0557 0.2364 0.4895
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2311 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.02 0.0808 0.0808
Leishmania major protein kinase, putative 0.0124 0.0479 0.0965
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Plasmodium falciparum cysteine repeat modular protein 1 0.0062 0.0208 0.0558
Onchocerca volvulus 0.047 0.1984 0.4137
Loa Loa (eye worm) hypothetical protein 0.035 0.1463 0.1463
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0082 0.0167
Loa Loa (eye worm) cysteine protease 0.0795 0.3398 0.3398
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0808 0.2166
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Loa Loa (eye worm) hypothetical protein 0.0795 0.3398 0.3398
Schistosoma mansoni calpain (C02 family) 0.0857 0.367 0.367
Loa Loa (eye worm) hypothetical protein 0.0045 0.0133 0.0132
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Giardia lamblia Dipeptidyl-peptidase I precursor 0.02 0.0808 0.2166
Plasmodium falciparum plasmepsin IV 0.0047 0.0143 0.0368
Echinococcus granulosus calpain A 0.209 0.9038 0.9038
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2087 0.9026 0.9026
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0669 0.2851 0.591
Loa Loa (eye worm) matrixin family protein 0.0052 0.0166 0.0165
Echinococcus granulosus cathepsin b 0.2311 1 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0857 0.367 0.367
Trypanosoma brucei hypothetical protein 0.0613 0.2605 0.5398
Leishmania major cathepsin L-like protease 0.0937 0.4017 0.8342
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0853 0.3651 0.3651
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0082 0.0223
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.0808 0.0808
Loa Loa (eye worm) fibroinase 0.0795 0.3398 0.3398
Echinococcus granulosus cathepsin l1 0.0554 0.2348 0.2348
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.02 0.0808 0.22
Brugia malayi Calmodulin-like protein 0.0124 0.0479 0.0479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0344 0.0344
Echinococcus granulosus cathepsin l cysteine peptidase 0.0795 0.3398 0.3398
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0896 0.3841 0.383
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0095 0.0095
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0413 0.1735 0.1735
Onchocerca volvulus 0.0795 0.3398 0.7134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.0808 0.2166
Onchocerca volvulus 0.0795 0.3398 0.7134
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.0808 0.2166
Onchocerca volvulus 0.0795 0.3398 0.7134
Echinococcus granulosus cysteine protease 0.0441 0.1858 0.1858
Brugia malayi Cytochrome P450 family protein 0.0036 0.0092 0.0092
Onchocerca volvulus Peroxidasin homolog 0.0064 0.0218 0.0394
Loa Loa (eye worm) calpain 0.0857 0.367 0.367
Loa Loa (eye worm) myosin regulatory light chain 1 0.0027 0.0055 0.0055
Brugia malayi Trypsin family protein 0.0033 0.0082 0.0082
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Loa Loa (eye worm) matrixin family protein 0.0048 0.0147 0.0146
Trypanosoma brucei calpain-like protein, putative 0.0857 0.367 0.7618
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.02 0.0808 0.22
Brugia malayi Cathepsin L-like precursor 0.0554 0.2348 0.2348
Onchocerca volvulus 0.006 0.0197 0.0351
Schistosoma mansoni neuronal calcium sensor 0.0124 0.0479 0.0479
Leishmania major kinesin, putative 0.0507 0.2144 0.4437
Trypanosoma brucei calpain-like protein, putative 0.0857 0.367 0.7618
Trichomonas vaginalis conserved hypothetical protein 0.035 0.1463 0.3972
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.0892 0.8915
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0064 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1397 0.3791
Schistosoma mansoni neuronal calcium sensor 0.0124 0.0479 0.0479
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0047 0.0128
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0052 0.0365
Onchocerca volvulus 0.0033 0.0082 0.0108
Loa Loa (eye worm) calpain D 0.035 0.1463 0.1463
Trypanosoma cruzi centrin, putative 0.0152 0.0597 0.0582
Plasmodium vivax unspecified product 0.0441 0.1858 0.5062
Leishmania major calmodulin-like protein 0.0124 0.0479 0.0965
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0022
Onchocerca volvulus 0.0029 0.0064 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0838 0.0823
Echinococcus multilocularis calmodulin 0.0124 0.0479 0.0479
Schistosoma mansoni calpain C (C02 family) 0.0857 0.367 0.367
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0022 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0441 0.1858 0.5438
Leishmania major hypothetical protein, conserved 0.0335 0.1397 0.2879
Loa Loa (eye worm) hypothetical protein 0.02 0.0808 0.0807
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0047 0.0031
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0082 0.0082
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0095 0.0797
Schistosoma mansoni ef hand domain family member A2 0.0124 0.0479 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Brugia malayi cytochrome P450 0.0018 0.0016 0.0016
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Toxoplasma gondii microneme protein MIC4 0.0029 0.0064 0.013
Echinococcus granulosus neurocalcin 0.0124 0.0479 0.0479
Echinococcus granulosus EF HAND 1 calcium binding site 0.0124 0.0479 0.0479
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0557 0.2364 0.2352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Echinococcus multilocularis cathepsin L 0.0441 0.1858 0.1858
Leishmania major hypothetical protein, conserved 0.0207 0.0838 0.1714
Giardia lamblia Dipeptidyl-peptidase I precursor 0.02 0.0808 0.2166
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.2087 0.9026 0.9026
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0064 0.0063
Entamoeba histolytica calcium binding family protein 0.0124 0.0479 0.1354
Echinococcus granulosus centrin 2 0.0124 0.0479 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Echinococcus multilocularis bloom syndrome protein 0.0021 0.003 0.003
Echinococcus multilocularis enteropeptidase 0.0033 0.0082 0.0082
Entamoeba histolytica cysteine proteinase, putative 0.0441 0.1858 0.5438
Mycobacterium tuberculosis Probable oxidoreductase 0.0244 0.0998 1
Plasmodium vivax glutathione reductase, putative 0.0096 0.0356 0.0968
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0356 0.0968
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0047 0.0031
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0033 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0063
Brugia malayi Cathepsin L-like precursor 0.0795 0.3398 0.3398
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0005
Mycobacterium ulcerans hydrolase 0.0026 0.0052 0.458
Giardia lamblia Cysteine protease 0.02 0.0808 0.2166
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0095 0.0257
Echinococcus granulosus EF hand domain containing family member A2 0.0124 0.0479 0.0479
Trypanosoma brucei calmodulin, putative 0.0124 0.0479 0.0965
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0095 0.0095
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.02 0.0808 0.2334
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0124 0.0479 0.0965
Plasmodium vivax plasmepsin IV, putative 0.0047 0.0143 0.039
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0557 0.2364 0.2352
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0701 0.2991 0.2979
Entamoeba histolytica hypothetical protein, conserved 0.0127 0.0491 0.1391
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0532 0.0532
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.035 0.1463 0.3972
Giardia lamblia Cathepsin B precursor 0.0853 0.3651 1
Brugia malayi Blistered cuticle protein 3 0.0064 0.0218 0.0218
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0029 0.0064 0.013
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0262 0.1079 0.2217
Onchocerca volvulus 0.0033 0.0082 0.0108
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0095 0.0201
Trichomonas vaginalis calpain, putative 0.035 0.1463 0.3972
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.0892 0.8915
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0539 0.2287 0.2274
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0838 0.0823
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0124 0.0479 0.126
Mycobacterium ulcerans lipase LipD 0.0036 0.0095 1
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Schistosoma mansoni reticulocalbin 0.0124 0.0479 0.0479
Trypanosoma brucei calpain, putative 0.035 0.1463 0.3016
Toxoplasma gondii EFHC1, putative 0.0124 0.0479 0.1273
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0795 0.3398 0.3398
Toxoplasma gondii hypothetical protein 0.0029 0.0064 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0344 0.0344
Brugia malayi Animal haem peroxidase family protein 0.0064 0.0218 0.0218
Leishmania major centrin, putative 0.0124 0.0479 0.0965
Trypanosoma cruzi I/6 autoantigen, putative 0.0124 0.0479 0.0463
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0095 0.0163
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0127 0.0491 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Leishmania major cathepsin L-like protease 0.0795 0.3398 0.7052
Brugia malayi Trypsin family protein 0.0033 0.0082 0.0082
Plasmodium vivax vivapain-2 0.0795 0.3398 0.926
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.0143 0.0143
Leishmania major hypothetical protein, conserved 0.0036 0.0095 0.0163
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0027 0.0055 0.0093
Schistosoma mansoni cpg binding protein 0.003 0.0067 0.0067
Plasmodium falciparum centrin-4 0.0027 0.0055 0.0107
Plasmodium falciparum cysteine proteinase falcipain 3 0.0795 0.3398 1
Trichomonas vaginalis kakapo, putative 0.0027 0.0055 0.0093
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0241 0.0987 0.0987
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0488 0.0488
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4017 0.4008
Giardia lamblia Cathepsin L precursor 0.02 0.0808 0.2166
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0795 0.3398 0.3398
Entamoeba histolytica cysteine proteinase, putative 0.0441 0.1858 0.5438
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0124 0.0479 0.0479
Leishmania major small myristoylated protein-2 0.065 0.277 0.5742
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0669 0.2851 0.2839
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Toxoplasma gondii centrin 0.0124 0.0479 0.1273
Mycobacterium tuberculosis Conserved protein 0.0036 0.0095 0.0797
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1119 0.4812 0.4804
Trichomonas vaginalis calmodulin, putative 0.0027 0.0055 0.0093
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0795 0.3398 0.3398
Trypanosoma cruzi conserved protein 0.0566 0.2403 0.239
Schistosoma mansoni hypothetical protein 0.017 0.0678 0.0678
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0082 0.8406
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0896 0.3841 0.7974
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0031
Mycobacterium tuberculosis Conserved protein 0.0036 0.0095 0.0797
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0047 0.0084
Onchocerca volvulus 0.0036 0.0095 0.0134
Echinococcus granulosus cathepsin L cysteine proteinase 0.0795 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0012
Echinococcus granulosus calcyphosin protein 0.0027 0.0055 0.0055
Leishmania major centrin, putative 0.0124 0.0479 0.0965
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Echinococcus multilocularis EF hand domain containing family member A2 0.0127 0.0491 0.0491
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0011 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0344 0.0344
Echinococcus multilocularis Ankyrin 0.0015 0.0001 0.0001
Schistosoma mansoni peroxidasin 0.0064 0.0218 0.0218
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.035 0.1463 0.3016
Onchocerca volvulus 0.0064 0.0218 0.0394
Plasmodium vivax prefoldin subunit 6, putative 0.0031 0.0071 0.0192
Giardia lamblia Cathepsin B precursor 0.0853 0.3651 1
Schistosoma mansoni hypothetical protein 0.0031 0.0071 0.0071
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0219 0.0892 0.8915
Brugia malayi Matrixin family protein 0.0022 0.0032 0.0032
Plasmodium falciparum cysteine proteinase falcipain 1 0.0441 0.1858 0.5442
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0539 0.2287 0.4734
Onchocerca volvulus 0.0029 0.0064 0.0068
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Onchocerca volvulus 0.0028 0.006 0.0059
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0033 0.0082 0.0082
Trichomonas vaginalis myosin light chain 1, putative 0.0124 0.0479 0.126
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0853 0.3651 0.7578
Trypanosoma cruzi cruzipain precursor, putative 0.0241 0.0987 0.0973
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0302 0.1254 0.2581
Trypanosoma brucei centrin-3 0.0152 0.0597 0.1211
Brugia malayi intermediate filament protein 0.0053 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0062 0.0208 0.0207
Onchocerca volvulus 0.0053 0.017 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0124 0.0479 0.0965
Leishmania major hypothetical protein, conserved 0.0207 0.0838 0.1714
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.017 0.017
Entamoeba histolytica calcium-binding protein, putative 0.0124 0.0479 0.1354
Plasmodium falciparum plasmepsin II 0.0047 0.0143 0.0368
Trypanosoma brucei hypothetical protein, conserved 0.0335 0.1397 0.2879
Trypanosoma cruzi cysteine protease, putative 0.0441 0.1858 0.1845
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.0892 0.8915
Brugia malayi calcium-binding protein 0.0124 0.0479 0.0479
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.02 0.0808 0.22
Brugia malayi Trypsin family protein 0.0033 0.0082 0.0082
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0092 0.9658
Trypanosoma brucei trypanothione reductase 0.0096 0.0356 0.0707
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0127 0.0491 0.0476
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0047 0.0143 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.02 0.0808 0.2166
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0078
Trypanosoma brucei Calpain-like protein 1.1 0.0896 0.3841 0.7974
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.02 0.0808 0.0808
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0027 0.0055 0.005
Trypanosoma cruzi prefoldin subunit, putative 0.0031 0.0071 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0063
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0022 0.0662
Echinococcus multilocularis calcium uptake protein 1 0.0127 0.0491 0.0491
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0022
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0356 0.034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0094
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0027 0.0055 0.005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0207 0.0207
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0062 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0838 0.0823
Loa Loa (eye worm) hypothetical protein 0.1456 0.6277 0.6277
Loa Loa (eye worm) hypothetical protein 0.02 0.0808 0.0807
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0441 0.1858 0.1858
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0557 0.2364 0.2352
Giardia lamblia Hypothetical protein 0.02 0.0808 0.2166
Trypanosoma cruzi unspecified product 0.0357 0.1492 0.1478
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2087 0.9026 0.9026
Brugia malayi hypothetical protein 0.0016 0.0008 0.0008
Toxoplasma gondii centrin family protein 0.0027 0.0055 0.0107
Loa Loa (eye worm) hypothetical protein 0.0124 0.0479 0.0478
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1046 0.4494 0.4485
Trichomonas vaginalis centrin, putative 0.0027 0.0055 0.0093
Loa Loa (eye worm) EF hand family protein 0.0124 0.0479 0.0478
Trypanosoma cruzi hypothetical protein, conserved 0.0335 0.1397 0.1383
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0092 0.0091
Trichomonas vaginalis hypothetical protein 0.035 0.1463 0.3972
Loa Loa (eye worm) hypothetical protein 0.02 0.0808 0.0807
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0033 0.0082 0.0082
Giardia lamblia Hypothetical protein 0.02 0.0808 0.2166
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0095 0.0797
Entamoeba histolytica papain family cysteine protease domain containing protein 0.02 0.0808 0.2328
Echinococcus granulosus programmed cell death protein 0.0152 0.0597 0.0597
Toxoplasma gondii hypothetical protein 0.035 0.1463 0.3981
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0095 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0344 0.0344
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0896 0.3841 0.383
Giardia lamblia Programmed cell death protein-like protein 0.0027 0.0055 0.0093
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.0218 0.0217
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0281 0.0281
Entamoeba histolytica cysteine proteinase, putative 0.0795 0.3398 1
Plasmodium falciparum centrin-1 0.0124 0.0479 0.1361
Plasmodium falciparum serine repeat antigen 4 0.02 0.0808 0.2334
Schistosoma mansoni hypothetical protein 0.0124 0.0479 0.0479
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0033 0.0082 0.0082
Echinococcus multilocularis neuronal calcium sensor 0.0124 0.0479 0.0479
Loa Loa (eye worm) calpain family protein 1 0.1963 0.8484 0.8484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0441 0.1858 0.506
Loa Loa (eye worm) hypothetical protein 0.0053 0.017 0.0169
Brugia malayi Cytochrome P450 family protein 0.0036 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.0808 0.2166
Giardia lamblia Cysteine protease 0.02 0.0808 0.2166
Schistosoma mansoni lamin 0.0053 0.017 0.017
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1963 0.8484 0.8484
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0055 0.0039
Loa Loa (eye worm) hypothetical protein 0.0554 0.2348 0.2348
Brugia malayi Trypsin family protein 0.0033 0.0082 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0011
Plasmodium vivax serine-repeat antigen (SERA) 0.02 0.0808 0.22
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Plasmodium falciparum serine repeat antigen 9 0.02 0.0808 0.2334
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0055
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0613 0.2605 0.5398
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0124 0.0479 0.0463
Trichomonas vaginalis calpain, putative 0.035 0.1463 0.3972
Trypanosoma cruzi calmodulin, putative 0.0124 0.0479 0.0463
Toxoplasma gondii microneme protein MIC17C 0.0029 0.0064 0.013
Plasmodium falciparum serine repeat antigen 3 0.02 0.0808 0.2334
Loa Loa (eye worm) hypothetical protein 0.0554 0.2348 0.2348
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Leishmania major hypothetical protein, conserved 0.0062 0.0208 0.0399
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.006 0.0059
Giardia lamblia Cathepsin L precursor 0.02 0.0808 0.2166
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Schistosoma mansoni calmodulin 0.0124 0.0479 0.0479
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0064 0.0063
Schistosoma mansoni cathepsin S (C01 family) 0.02 0.0808 0.0808
Echinococcus granulosus cathepsin L cysteine protease 0.0441 0.1858 0.1858
Onchocerca volvulus Chorion peroxidase homolog 0.0064 0.0218 0.0394
Toxoplasma gondii microneme protein, putative 0.0029 0.0064 0.013
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1119 0.4812 0.4804
Schistosoma mansoni cathepsin F (C01 family) 0.0795 0.3398 0.3398
Leishmania major cysteine peptidase A (CPA) 0.0795 0.3398 0.7052
Trypanosoma cruzi kinesin, putative 0.0507 0.2144 0.2131
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Entamoeba histolytica cysteine proteinase 1, putative 0.0441 0.1858 0.5438
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0244 0.0998 1
Brugia malayi Hemopexin family protein 0.0031 0.0071 0.0071
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1119 0.4812 1
Brugia malayi Kringle domain containing protein 0.0062 0.0208 0.0208
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0082 0.0223
Entamoeba histolytica cysteine proteinase, putative 0.0795 0.3398 1
Leishmania major programmed cell death 6 protein-like protein 0.0124 0.0479 0.0965
Trichomonas vaginalis calmodulin, putative 0.0124 0.0479 0.126
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0052
Giardia lamblia Cathepsin L precursor 0.02 0.0808 0.2166
Entamoeba histolytica cysteine protease, putative 0.02 0.0808 0.2328
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0857 0.367 0.366
Onchocerca volvulus 0.0795 0.3398 0.7134
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0207 0.0838 0.1714
Entamoeba histolytica cysteine protease, putative 0.0795 0.3398 1
Echinococcus granulosus geminin 0.017 0.0678 0.0678
Brugia malayi EF hand family protein 0.0124 0.0479 0.0479
Schistosoma mansoni neuronal calcium sensor 0.0124 0.0479 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Plasmodium falciparum serine repeat antigen 6 0.02 0.0808 0.2334
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1119 0.4812 0.4804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0441 0.1858 0.384
Brugia malayi Animal haem peroxidase family protein 0.0064 0.0218 0.0218
Loa Loa (eye worm) glutathione reductase 0.0096 0.0356 0.0355
Giardia lamblia Cathepsin L precursor 0.02 0.0808 0.2166
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Echinococcus granulosus calmodulin 0.0124 0.0479 0.0479
Brugia malayi Matrixin family protein 0.0022 0.0032 0.0032
Loa Loa (eye worm) blistered cuticle protein 3 0.0064 0.0218 0.0217
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0137
Trichomonas vaginalis calcium binding protein, putative 0.0124 0.0479 0.126
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.02 0.0808 0.2334
Echinococcus multilocularis cathepsin L cysteine protease 0.0795 0.3398 0.3398
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0095 0.0797
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0441 0.1858 0.1858
Giardia lamblia Cysteine protease 0.02 0.0808 0.2166
Echinococcus granulosus peroxidasin 0.0064 0.0218 0.0218
Onchocerca volvulus 0.0795 0.3398 0.7134
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0207 0.0838 0.1714
Onchocerca volvulus 0.1105 0.4751 1
Leishmania major small myristoylated protein-3, putative 0.0302 0.1254 0.2581
Loa Loa (eye worm) cathepsin B 0.0853 0.3651 0.365
Echinococcus granulosus tissue type plasminogen activator 0.0062 0.0208 0.0208
Brugia malayi Papain family cysteine protease containing protein 0.0441 0.1858 0.1858
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.0808 0.2166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.0808 0.2166
Giardia lamblia Cathepsin L-like protease 0.02 0.0808 0.2166
Loa Loa (eye worm) hypothetical protein 0.1963 0.8484 0.8484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.0808 0.2166
Trypanosoma brucei unspecified product 0.0207 0.0838 0.1714
Brugia malayi EF hand family protein 0.0127 0.0491 0.0491
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0302 0.1254 0.124
Loa Loa (eye worm) hypothetical protein 0.0031 0.0071 0.007
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0095 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Trichomonas vaginalis calcium binding protein, putative 0.0124 0.0479 0.126
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0466 0.0465
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0147 0.0244
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0124 0.0479 0.0479
Leishmania major centrin, putative,caltractin, putative 0.0124 0.0479 0.0965
Echinococcus multilocularis cysteine protease 0.0795 0.3398 0.3398
Trypanosoma cruzi centrin, putative 0.0152 0.0597 0.0582
Brugia malayi hypothetical protein 0.0148 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0241 0.0987 0.0987
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0466 0.0465
Leishmania major cathepsin L-like protease 0.0937 0.4017 0.8342
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.0892 0.8915
Leishmania major hypothetical protein, conserved 0.0124 0.0479 0.0965
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0094
Onchocerca volvulus 0.0036 0.0095 0.0134
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Trichomonas vaginalis centrin, putative 0.0027 0.0055 0.0093
Trypanosoma cruzi cysteine proteinase, putative 0.0441 0.1858 0.1845
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0896 0.3841 0.7974
Trichomonas vaginalis calcium binding protein, putative 0.0027 0.0055 0.0093
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.02 0.0808 0.22
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0356 0.0355
Schistosoma mansoni myosin regulatory light chain 0.0027 0.0055 0.0055
Echinococcus multilocularis cathepsin b 0.2311 1 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0857 0.367 0.367
Schistosoma mansoni hypothetical protein 0.017 0.0678 0.0678
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0075 0.0058
Loa Loa (eye worm) hypothetical protein 0.0241 0.0987 0.0987
Giardia lamblia Cathepsin B precursor 0.02 0.0808 0.2166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0344 0.0344
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Trypanosoma cruzi centrin-3 0.0152 0.0597 0.0582
Trypanosoma brucei calpain, putative 0.0613 0.2605 0.5398
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0795 0.3398 0.3398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0207 0.0838 0.1714
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0476 0.2012 0.1999
Giardia lamblia Cathepsin B precursor 0.02 0.0808 0.2166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0197 0.0197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0066
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0896 0.3841 0.7974
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0082 0.0137
Trypanosoma cruzi calmodulin, putative 0.0124 0.0479 0.0463
Onchocerca volvulus 0.0036 0.0095 0.0134
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0794 0.3395 0.7044
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0022
Echinococcus granulosus lamin 0.0053 0.017 0.017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0005
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.035 0.1463 0.3972
Trichomonas vaginalis caltractin, putative 0.0027 0.0055 0.0093
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.02 0.0808 0.0807
Schistosoma mansoni mitochondrial solute carrier 0.0124 0.0479 0.0479
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0259 0.0259
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0207 0.0838 0.0823
Trichomonas vaginalis calpain, putative 0.035 0.1463 0.3972
Echinococcus multilocularis 0.0018 0.0016 0.0016
Brugia malayi Cathepsin L-like precursor 0.0241 0.0987 0.0987
Mycobacterium tuberculosis Probable reductase 0.0219 0.0892 0.8915
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1046 0.4494 0.4485
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0335 0.1397 0.1383
Onchocerca volvulus 0.0124 0.0479 0.0948
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Echinococcus multilocularis hypothetical protein 0.0857 0.367 0.367
Plasmodium vivax vivapain-3 0.0441 0.1858 0.5062
Brugia malayi hypothetical protein 0.0033 0.0082 0.0082
Trypanosoma brucei protein I/6 0.0124 0.0479 0.0965
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0943 0.944
Onchocerca volvulus 0.0148 0.058 0.1161
Echinococcus granulosus calbindin 32 0.0127 0.0491 0.0491
Echinococcus multilocularis calpain A 0.209 0.9038 0.9038
Toxoplasma gondii prefoldin subunit 6, putative 0.0031 0.0071 0.015
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0241 0.0987 0.0987
Echinococcus multilocularis transmembrane protease serine 3 0.0033 0.0082 0.0082
Trichomonas vaginalis calmodulin, putative 0.0124 0.0479 0.126
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0082 0.5
Trypanosoma brucei mitochondrial calcium uptake 1 0.0124 0.0479 0.0965
Schistosoma mansoni hypothetical protein 0.0033 0.0082 0.0082
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.2087 0.9026 0.9026
Giardia lamblia Hypothetical protein 0.0031 0.0071 0.0136
Toxoplasma gondii EF hand domain-containing protein 0.0124 0.0479 0.1273
Schistosoma mansoni hypothetical protein 0.0033 0.0082 0.0082
Trichomonas vaginalis set domain proteins, putative 0.047 0.1983 0.5406
Schistosoma mansoni hypothetical protein 0.0124 0.0479 0.0479
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0033 0.0082 0.0082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0857 0.367 0.366
Echinococcus multilocularis Calcium binding protein 0.0027 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0857 0.367 0.366
Trypanosoma brucei conserved protein 0.0216 0.0877 0.1794
Brugia malayi Matrixin family protein 0.0022 0.0032 0.0032
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0207 0.0838 0.0823
Toxoplasma gondii calcium binding protein precursor, putative 0.0027 0.0055 0.0107
Echinococcus multilocularis glycoprotein Antigen 5 0.0033 0.0082 0.0082
Giardia lamblia Cathepsin L precursor 0.02 0.0808 0.2166
Brugia malayi Peroxidasin 0.0064 0.0218 0.0218
Toxoplasma gondii preprocathepsin c precursor, putative 0.02 0.0808 0.2177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0066
Toxoplasma gondii ABC1 family protein 0.0036 0.0095 0.0215
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Brugia malayi hypothetical protein 0.0025 0.0047 0.0047
Plasmodium vivax vivapain-2 0.0795 0.3398 0.926
Schistosoma mansoni hypothetical protein 0.0018 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0344 0.0344
Trypanosoma cruzi cysteine peptidase, putative 0.0795 0.3398 0.3388
Brugia malayi MH2 domain containing protein 0.0121 0.0466 0.0466
Entamoeba histolytica grainin 2 0.0152 0.0597 0.1705
Echinococcus granulosus lamin dm0 0.0053 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Onchocerca volvulus 0.0033 0.0082 0.0108
Toxoplasma gondii microneme protein MIC17B 0.0029 0.0064 0.013
Onchocerca volvulus 0.0029 0.0064 0.0068
Trichomonas vaginalis calmodulin, putative 0.0124 0.0479 0.126
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4017 0.4008
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0207 0.0838 0.1714
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0047 0.0085
Giardia lamblia Cathepsin B precursor 0.02 0.0808 0.2166
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.02 0.0808 0.2334
Trypanosoma brucei calmodulin, putative 0.0127 0.0491 0.099
Onchocerca volvulus 0.0029 0.0064 0.0068
Schistosoma mansoni cathepsin C 0.02 0.0808 0.0808
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0064 0.0063
Trypanosoma brucei cysteine peptidase C (CPC) 0.0853 0.3651 0.7578
Leishmania major calpain family cysteine protease-like protein 0.0557 0.2364 0.4895
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.02 0.0808 0.2166
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0082 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0857 0.367 0.7618
Leishmania major hypothetical protein, conserved 0.0207 0.0838 0.1714
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.003 0.003
Echinococcus granulosus dna polymerase eta 0.0045 0.0133 0.0133
Trichomonas vaginalis calmodulin, putative 0.0124 0.0479 0.126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0095 0.0797
Brugia malayi calpain family protein 1 0.1963 0.8484 0.8484
Trichomonas vaginalis calmodulin, putative 0.0124 0.0479 0.126
Schistosoma mansoni cathepsin s 0.0241 0.0987 0.0987
Brugia malayi beta-lactamase family protein 0.0036 0.0095 0.0095
Plasmodium falciparum serine repeat antigen 2 0.02 0.0808 0.2334
Onchocerca volvulus 0.0064 0.0218 0.0394
Trypanosoma brucei centrin, putative 0.0124 0.0479 0.0965
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Brugia malayi cathepsin Z-like cysteine proteinase 0.02 0.0808 0.0808
Schistosoma mansoni hypothetical protein 0.0052 0.0163 0.0163
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0047 0.0143 0.0336
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0545 0.0545
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0259 0.0259
Onchocerca volvulus 0.0124 0.0479 0.0948
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0124 0.0479 0.0463
Echinococcus multilocularis dna polymerase eta 0.0045 0.0133 0.0133
Plasmodium vivax aspartyl proteinase, putative 0.0047 0.0143 0.039
Loa Loa (eye worm) hypothetical protein 0.1612 0.6958 0.6958
Plasmodium falciparum glutathione reductase 0.0096 0.0356 0.0996
Echinococcus multilocularis calcyphosin protein 0.0027 0.0055 0.0055
Echinococcus multilocularis musashi 0.0053 0.017 0.017
Echinococcus granulosus Myosin regulatory light chain 0.0027 0.0055 0.0055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.2348 0.6411
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0207 0.0838 0.1714
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0441 0.1858 0.1858
Brugia malayi Cathepsin L-like precursor 0.0795 0.3398 0.3398
Onchocerca volvulus Peroxidasin homolog 0.0064 0.0218 0.0394
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0045
Onchocerca volvulus 0.0795 0.3398 0.7134
Leishmania major cathepsin L-like protease 0.0795 0.3398 0.7052
Trypanosoma cruzi I/6 autoantigen, putative 0.0124 0.0479 0.0463
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0032 0.0031
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0207 0.0838 0.1714
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0197 0.0197
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1119 0.4812 0.4804
Plasmodium falciparum plasmepsin VI 0.0047 0.0143 0.0368
Giardia lamblia Cathepsin L precursor 0.02 0.0808 0.2166
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.02 0.0808 0.0808
Toxoplasma gondii aspartyl protease ASP1 0.0047 0.0143 0.035
Entamoeba histolytica calmodulin, putative 0.0124 0.0479 0.1354
Entamoeba histolytica protein kinase, putative 0.0507 0.2144 0.6285
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0696 0.2967 0.2956
Onchocerca volvulus 0.0064 0.0218 0.0394
Trypanosoma brucei small myristoylated protein 1-1 0.0357 0.1492 0.3076
Trypanosoma cruzi cysteine proteinase, putative 0.0441 0.1858 0.1845
Loa Loa (eye worm) hypothetical protein 0.0319 0.1325 0.1325
Brugia malayi Cathepsin L-like precursor 0.0795 0.3398 0.3398
Loa Loa (eye worm) calpain family protein 1 0.1456 0.6277 0.6277
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.02 0.0808 0.2166
Leishmania major trypanothione reductase 0.0096 0.0356 0.0707
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0197 0.0498
Schistosoma mansoni intermediate filament proteins 0.0053 0.017 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Plasmodium vivax SET domain protein, putative 0.006 0.0197 0.0537
Echinococcus granulosus dna polymerase kappa 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.0197
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Entamoeba histolytica calmodulin, putative 0.0124 0.0479 0.1354
Brugia malayi Animal haem peroxidase family protein 0.0064 0.0218 0.0218
Entamoeba histolytica cysteine protease, putative 0.02 0.0808 0.2328
Trichomonas vaginalis centrin, putative 0.0124 0.0479 0.126
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0064 0.0063
Trichomonas vaginalis calmodulin, putative 0.0127 0.0491 0.1295
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0092 0.0091
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0095 0.0095
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Echinococcus granulosus calpain 5 0.0857 0.367 0.367
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Trypanosoma brucei calpain-like protein, putative 0.0857 0.367 0.7618
Brugia malayi Cytochrome P450 family protein 0.0037 0.0097 0.0097
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0064 0.013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.0532 0.0532
Onchocerca volvulus 0.0033 0.0082 0.0108
Plasmodium falciparum serine repeat antigen 1 0.02 0.0808 0.2334
Schistosoma mansoni centrin-related 0.0124 0.0479 0.0479
Trypanosoma cruzi major cysteine proteinase, putative 0.02 0.0808 0.0793
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0853 0.3652 0.7581
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0185 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.0808 0.2166
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0082 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0302 0.1254 0.2581
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2311 1 1
Brugia malayi Thioredoxin reductase 0.0096 0.0356 0.0356
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0095 1
Toxoplasma gondii cathepsin B 0.0853 0.3651 1
Leishmania major hypothetical protein, conserved 0.0207 0.0838 0.1714
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0047 0.0084
Plasmodium vivax serine-repeat antigen (SERA), putative 0.02 0.0808 0.22
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Schistosoma mansoni centrin 0.0124 0.0479 0.0479
Schistosoma mansoni cathepsin F (C01 family) 0.0795 0.3398 0.3398
Brugia malayi cathepsin L-like cysteine proteinase 0.02 0.0808 0.0808
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0005
Echinococcus granulosus cathepsin L 0.02 0.0808 0.0808
Schistosoma mansoni myosin regulatory light chain 0.0027 0.0055 0.0055
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.003 0.0025
Onchocerca volvulus Matrilysin homolog 0.0048 0.0147 0.0244
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0027 0.0055 0.015
Entamoeba histolytica grainin, putative 0.0127 0.0491 0.1391
Schistosoma mansoni hypothetical protein 0.0031 0.0071 0.0071
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0082 0.0137
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0082 0.0082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0896 0.3841 0.383
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0082 0.0186
Onchocerca volvulus 0.0029 0.0064 0.0068
Loa Loa (eye worm) hypothetical protein 0.02 0.0808 0.0807
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0853 0.3651 0.364
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.035 0.1463 0.3016
Echinococcus multilocularis cathepsin L 0.02 0.0808 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.2348 0.6411
Onchocerca volvulus Peroxidase homolog 0.0064 0.0218 0.0394
Toxoplasma gondii cathepsin CPC2 0.02 0.0808 0.2177
Echinococcus multilocularis calpain 5 0.0857 0.367 0.367
Leishmania major small myristoylated protein 4, putative 0.0563 0.2387 0.4944
Leishmania major DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0053 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0047
Schistosoma mansoni cathepsin B (C01 family) 0.02 0.0808 0.0808
Echinococcus granulosus cathepsin b 0.2311 1 1
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Trichomonas vaginalis centrin, putative 0.0124 0.0479 0.126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0011
Loa Loa (eye worm) ctsf protein 0.0795 0.3398 0.3398
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.0808 0.2166
Giardia lamblia Cathepsin B precursor 0.0853 0.3651 1
Leishmania major cytochrome p450-like protein 0.0036 0.0092 0.0158
Loa Loa (eye worm) trypsin family protein 0.0033 0.0082 0.0082
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0557 0.2364 0.2352
Brugia malayi cathepsin Z-like cysteine proteinase 0.02 0.0808 0.0808
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0853 0.3652 0.7581
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Entamoeba histolytica cysteine protease, putative 0.02 0.0808 0.2328
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1119 0.4812 1
Onchocerca volvulus 0.0029 0.0064 0.0068
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0047 0.0143 0.035
Loa Loa (eye worm) calmodulin-like protein 0.0124 0.0479 0.0478
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0082 0.0066
Leishmania major i/6 autoantigen-like protein 0.0124 0.0479 0.0965
Brugia malayi Cathepsin L-like precursor 0.0554 0.2348 0.2348
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Echinococcus granulosus cathepsin L 0.0441 0.1858 0.1858
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Onchocerca volvulus 0.0053 0.017 0.0293
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0557 0.2364 0.2352
Loa Loa (eye worm) RecQ helicase 0.0021 0.003 0.003
Trypanosoma brucei antigen, putative 0.0857 0.367 0.7618
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0262 0.1079 0.1065
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0082 0.8406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Schistosoma mansoni calpain-7 (C02 family) 0.0857 0.367 0.367
Trypanosoma brucei kinesin, putative 0.0507 0.2144 0.4437
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0095 0.0201
Trypanosoma brucei small myristoylated protein 1-2 0.0357 0.1492 0.3076
Trichomonas vaginalis calmodulin, putative 0.0124 0.0479 0.126
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0092 0.0091
Brugia malayi beta-lactamase 0.0036 0.0095 0.0095
Giardia lamblia Calmodulin 0.0027 0.0055 0.0093
Leishmania major calmodulin-like protein 0.0124 0.0479 0.0965
Schistosoma mansoni lamin 0.0053 0.017 0.017
Leishmania major DNA polymerase eta, putative 0.0032 0.0075 0.0122
Plasmodium vivax unspecified product 0.02 0.0808 0.22
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Toxoplasma gondii subtilisin SUB12 0.0029 0.0064 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0049
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Loa Loa (eye worm) myosin Light Chain family member 0.003 0.0068 0.0067
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.0441 0.1858 0.5438
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0539 0.2287 0.4734
Toxoplasma gondii troponin c, isotype gamma, putative 0.0124 0.0479 0.1273
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.02 0.0808 0.22
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0011
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0539 0.2287 0.4734
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0197 0.0197
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0197 0.0197
Trichomonas vaginalis esterase, putative 0.0036 0.0095 0.0201
Leishmania major hypothetical protein, conserved 0.0566 0.2403 0.4976
Echinococcus multilocularis calpain family protein 1, d 0.1456 0.6277 0.6277
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0241 0.0987 0.0987
Trichomonas vaginalis calcineurin B subunit, putative 0.0127 0.0491 0.1295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0479 0.126
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0082 0.0066
Schistosoma mansoni reticulocalbin 0.0127 0.0491 0.0491
Brugia malayi cathepsin L-like precursor 0.0554 0.2348 0.2348
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0356 0.3455
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0022 0.0053
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0244 0.0998 1
Echinococcus granulosus Ankyrin 0.0015 0.0001 0.0001
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0064 0.013
Echinococcus granulosus intermediate filament protein 0.0053 0.017 0.017
Schistosoma mansoni DNA polymerase eta 0.0045 0.0133 0.0133
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0047 0.0143 0.0143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2311 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Schistosoma mansoni calmodulin related calcium binding protein 0.0124 0.0479 0.0479
Schistosoma mansoni hypothetical protein 0.035 0.1463 0.1463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0063
Echinococcus multilocularis calbindin 32 0.0127 0.0491 0.0491
Mycobacterium leprae Probable lipase LipE 0.0036 0.0095 0.0797
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0207 0.0838 0.0823
Brugia malayi Cathepsin L-like cysteine proteinase 0.0554 0.2348 0.2348
Entamoeba histolytica cysteine proteinase 2 0.0441 0.1858 0.5438
Brugia malayi Animal haem peroxidase family protein 0.0064 0.0218 0.0218
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0124 0.0479 0.0463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.02 0.0808 0.2166
Echinococcus granulosus Calcium binding protein 0.0027 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.0165
Leishmania major phospholipase c-like protein 0.0124 0.0479 0.0965
Brugia malayi glutathione reductase 0.0096 0.0356 0.0356
Plasmodium vivax hypothetical protein, conserved 0.0127 0.0491 0.1338
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0124 0.0479 0.1304
Echinococcus multilocularis cpg binding protein 0.003 0.0067 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4017 0.4008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.0892 0.8915
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0049 0.0049
Trichomonas vaginalis calmodulin, putative 0.0124 0.0479 0.126
Schistosoma mansoni calpain-7 (C02 family) 0.0857 0.367 0.367
Loa Loa (eye worm) hypothetical protein 0.0554 0.2348 0.2348
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0133 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0066
Mycobacterium ulcerans beta-lactamase 0.0036 0.0095 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0011
Echinococcus granulosus prefoldin subunit 6 0.0031 0.0071 0.0071
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0095 0.0078
Brugia malayi Probable myosin regulatory light chain 0.003 0.0068 0.0068
Trichomonas vaginalis calcium binding protein, putative 0.0124 0.0479 0.126
Loa Loa (eye worm) hypothetical protein 0.2311 1 1
Toxoplasma gondii calcium-dependent protein kinase 0.0127 0.0491 0.1307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.035 0.1463 0.3972
Giardia lamblia Encystation-specific protease 0.02 0.0808 0.2166
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.035 0.1463 0.3972
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0701 0.2991 0.6202
Brugia malayi RasGEF domain containing protein 0.0027 0.0055 0.0055
Plasmodium vivax serine-repeat antigen (SERA), putative 0.02 0.0808 0.22
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0082 0.0167
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Onchocerca volvulus 0.0029 0.0064 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0853 0.3651 1
Plasmodium falciparum glutathione reductase 0.0033 0.0082 0.0186
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.02 0.0808 0.0808
Echinococcus granulosus cpg binding protein 0.003 0.0067 0.0067
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0095 0.0094
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0064 0.013
Mycobacterium ulcerans hypothetical protein 0.0036 0.0095 1
Echinococcus multilocularis prefoldin subunit 6 0.0031 0.0071 0.0071
Toxoplasma gondii PAN/Apple domain-containing protein 0.0029 0.0064 0.013
Brugia malayi Neuronal calcium sensor family protein 1 0.0027 0.0055 0.0055
Trypanosoma brucei caltractin, putative 0.0152 0.0597 0.1211
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Giardia lamblia Cysteine protease 0.02 0.0808 0.2166
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0207 0.0838 0.1714
Echinococcus granulosus glycoprotein Antigen 5 0.0033 0.0082 0.0082
Trichomonas vaginalis caltractin, putative 0.0027 0.0055 0.0093
Echinococcus granulosus bloom syndrome protein 0.0021 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0896 0.3841 0.7974
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0022 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0554 0.2348 0.689
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0092 0.0076
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0082 0.0137
Leishmania major calmodulin, putative 0.0124 0.0479 0.0965
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0047 0.0143 0.0143
Echinococcus granulosus transmembrane protease serine 3 0.0033 0.0082 0.0082
Brugia malayi cathepsin L precursor 0.02 0.0808 0.0808
Trypanosoma brucei Calpain-like protein 2 0.0683 0.2913 0.604
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0808 0.2166
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0557 0.2364 0.4895
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0055 0.0093
Echinococcus granulosus enteropeptidase 0.0033 0.0082 0.0082
Plasmodium falciparum prefoldin subunit 6, putative 0.0031 0.0071 0.0153
Mycobacterium tuberculosis Conserved protein 0.0036 0.0095 0.0797
Brugia malayi calpain 5 0.0507 0.2144 0.2144
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0095 0.0201
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0062 0.0208 0.0565
Schistosoma mansoni calpain-2 (C02 family) 0.035 0.1463 0.1463
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0262 0.1079 0.2217
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0539 0.2287 0.2274
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0302 0.1254 0.124
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0022 0.0662
Brugia malayi Matrixin family protein 0.0052 0.0166 0.0166
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0095 0.0797
Brugia malayi CXXC zinc finger family protein 0.0028 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.02 0.0808 0.2166
Trypanosoma brucei centrin, putative 0.0124 0.0479 0.0965
Plasmodium vivax centrin-1, putative 0.0124 0.0479 0.1304
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0795 0.3398 1
Onchocerca volvulus 0.0031 0.0071 0.0084
Toxoplasma gondii hypothetical protein 0.0029 0.0064 0.013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0795 0.3398 0.9305
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.02 0.0808 0.22
Brugia malayi KE2 family protein 0.0031 0.0071 0.0071
Plasmodium falciparum thioredoxin reductase 0.0096 0.0356 0.0996
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.02 0.0808 0.2166
Brugia malayi Protein kinase domain containing protein 0.0062 0.0208 0.0208
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0124 0.0479 0.0463
Brugia malayi calpain D 0.035 0.1463 0.1463
Schistosoma mansoni cpg binding protein 0.003 0.0067 0.0067
Echinococcus granulosus programmed cell death protein 6 0.003 0.0068 0.0068
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0701 0.2991 0.2979
Echinococcus multilocularis tissue type plasminogen activator 0.0062 0.0208 0.0208
Plasmodium vivax vivapain-1 0.0441 0.1858 0.5062
Mycobacterium ulcerans hypothetical protein 0.0033 0.0082 0.8444
Entamoeba histolytica cysteine protease, putative 0.02 0.0808 0.2328
Echinococcus multilocularis Myosin regulatory light chain 0.0027 0.0055 0.0055
Echinococcus multilocularis lamin 0.0053 0.017 0.017
Entamoeba histolytica calmodulin, putative 0.0027 0.0055 0.01
Onchocerca volvulus 0.0795 0.3398 0.7134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0005
Onchocerca volvulus 0.02 0.0808 0.1644
Leishmania major hypothetical protein, conserved 0.0127 0.0491 0.099
Trypanosoma cruzi small myristoylated protein 1-1 0.0357 0.1492 0.1478
Toxoplasma gondii kringle domain-containing protein 0.0062 0.0208 0.0527
Trypanosoma brucei prefoldin subunit, putative 0.0031 0.0071 0.0114
Brugia malayi hypothetical protein 0.0122 0.047 0.047
Echinococcus granulosus EF hand domain containing family member A2 0.0127 0.0491 0.0491
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.02 0.0808 0.2166
Schistosoma mansoni myosin light chain 0.0027 0.0055 0.0055
Trypanosoma cruzi caltractin, putative 0.0124 0.0479 0.0463
Toxoplasma gondii cathepsin CPC1 0.02 0.0808 0.2177
Giardia lamblia Cathepsin L-like protease 0.02 0.0808 0.2166
Entamoeba histolytica cysteine protease, putative 0.02 0.0808 0.2328
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0613 0.2605 0.5398
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0095 0.0797
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.0218 0.0217
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0557 0.2364 0.2352
Onchocerca volvulus 0.0029 0.0064 0.0068
Leishmania major cathepsin L-like protease 0.0795 0.3398 0.7052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0011
Giardia lamblia Cathepsin B precursor 0.02 0.0808 0.2166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0095 0.0078
Brugia malayi Pre-SET motif family protein 0.006 0.0197 0.0197
Brugia malayi Papain family cysteine protease containing protein 0.0441 0.1858 0.1858
Trypanosoma brucei I/6 autoantigen 0.0124 0.0479 0.0965
Leishmania major receptor-type adenylate cyclase a-like protein 0.0207 0.0838 0.1714
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0075 0.0161
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0356 0.0356
Schistosoma mansoni rab 0.0124 0.0479 0.0479
Brugia malayi Trypsin-like protease protein 5 0.0033 0.0082 0.0082
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1119 0.4812 1
Entamoeba histolytica grainin 2 0.0027 0.0055 0.01
Schistosoma mansoni neuronal calcium sensor 0.0124 0.0479 0.0479
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0094
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.035 0.1463 0.3972
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0557 0.2364 0.4895
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0853 0.3652 0.7581
Leishmania major cathepsin L-like protease 0.0795 0.3398 0.7052
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.0208 0.0207
Trypanosoma cruzi major cysteine proteinase, putative 0.0342 0.1427 0.1413
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.003 0.0025
Toxoplasma gondii calmodulin CAM2 0.0027 0.0055 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0441 0.1858 0.384
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0795 0.3398 0.9305
Toxoplasma gondii microneme protein MIC17A 0.0029 0.0064 0.013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.017 0.0169
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0082 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0082 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1046 0.4494 0.9335
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0262 0.1079 0.2217
Echinococcus granulosus calpain 7 C02 family 0.0857 0.367 0.367
Trypanosoma cruzi cysteine peptidase, putative 0.0241 0.0987 0.0973
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0062 0.0061
Brugia malayi calpain 5 0.035 0.1463 0.1463
Toxoplasma gondii cathepsin CPL 0.0795 0.3398 0.9306
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0683 0.2913 0.604
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0795 0.3398 0.3398
Onchocerca volvulus Cathepsin F homolog 0.0795 0.3398 0.7134
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Loa Loa (eye worm) cytochrome P450 0.0018 0.0016 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.0218 0.0217
Onchocerca volvulus 0.0027 0.0055 0.005
Schistosoma mansoni cpg binding protein 0.0028 0.006 0.006
Brugia malayi PAN domain containing protein 0.0029 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0031
Onchocerca volvulus 0.0033 0.0082 0.0108
Brugia malayi hypothetical protein 0.0064 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0055
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2311 1 1
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0532 0.0532
Leishmania major META domain containing protein 0.0207 0.0838 0.1714
Onchocerca volvulus Dual oxidase homolog 0.0064 0.0218 0.0394
Leishmania major cathepsin L-like protease 0.0937 0.4017 0.8342
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0082 0.0082
Echinococcus multilocularis calmodulin 0.0124 0.0479 0.0479
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0064 0.013
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0082 0.0186
Echinococcus multilocularis programmed cell death protein 0.0152 0.0597 0.0597
Onchocerca volvulus Cathepsin L homolog 0.0795 0.3398 0.7134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Loa Loa (eye worm) hypothetical protein 0.02 0.0808 0.0807
Echinococcus multilocularis centrin 2 0.0124 0.0479 0.0479
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0124 0.0479 0.0479
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0838 0.0823
Giardia lamblia Cathepsin B precursor 0.02 0.0808 0.2166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4017 0.8342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0795 0.3398 0.9305
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0441 0.1858 0.1845
Plasmodium vivax serine-repeat antigen (SERA) 0.02 0.0808 0.22
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0047 0.0065
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0082 0.0181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.02 0.0808 0.0807
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0124 0.0479 0.0479
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0095 0.0095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.0808 0.0808
Brugia malayi Cytochrome P450 family protein 0.0018 0.0016 0.0016
Trypanosoma cruzi cruzipain precursor, putative 0.0937 0.4017 0.4008
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0488 0.0488
Onchocerca volvulus Cathepsin L homolog 0.02 0.0808 0.1644
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0094
Plasmodium falciparum thioredoxin reductase 0.0033 0.0082 0.0186
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0082 0.0137
Leishmania major hypothetical protein, conserved 0.0207 0.0838 0.1714
Leishmania major DNA polymerase eta, putative 0.0045 0.0133 0.0243
Entamoeba histolytica calpain large subunit domain III containing protein 0.0507 0.2144 0.6285
Trypanosoma brucei Calpain-like protein 1.2 0.0701 0.2991 0.6202
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0208 0.0192
Toxoplasma gondii centrin, putative 0.0124 0.0479 0.1273
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0064 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0082 0.0082
Plasmodium falciparum serine repeat antigen 5 0.02 0.0808 0.2334
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0082 0.5
Toxoplasma gondii calmodulin CAM1 0.0127 0.0491 0.1307
Leishmania major hypothetical protein, conserved 0.0025 0.0047 0.0065
Echinococcus multilocularis programmed cell death protein 0.0152 0.0597 0.0597
Echinococcus multilocularis cysteine protease 0.0795 0.3398 0.3398
Entamoeba histolytica cysteine protease, putative 0.0441 0.1858 0.5438
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0082 0.0167
Trypanosoma cruzi calmodulin, putative 0.0124 0.0479 0.0463
Echinococcus multilocularis programmed cell death protein 6 0.003 0.0068 0.0068
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0244 0.0998 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0344 0.0344
Brugia malayi Papain family cysteine protease containing protein 0.02 0.0808 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.02 0.0808 0.2166
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0082 0.0137

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13 uM In vitro inhibitory activity against Cytochrome P450 19A1 using human placental microsomes. ChEMBL. 8632407
IC50 (binding) = 13 uM In vitro inhibitory activity against Cytochrome P450 19A1 using human placental microsomes. ChEMBL. 8632407
IC50 (binding) = 24 uM Inhibitory activity against Steroidgenic Cytochrome P450 C18 using Bovine adrenal mitochondria. ChEMBL. 8632407
IC50 (binding) = 24 uM Inhibitory activity against Steroidgenic Cytochrome P450 C18 using Bovine adrenal mitochondria. ChEMBL. 8632407
IC50 (binding) = 87 uM In vitro inhibitory activity against Steroidgenic Cytochrome P450 17 alpha using rat testicular microsomes. ChEMBL. 8632407
IC50 (binding) = 87 uM In vitro inhibitory activity against Steroidgenic Cytochrome P450 17 alpha using rat testicular microsomes. ChEMBL. 8632407
Inhibition (binding) = 98 % Inhibition of thromboxane A2 synthase in human whole blood. ChEMBL. 8632407
Inhibition (binding) = 98 % Inhibition of thromboxane A2 synthase in human whole blood. ChEMBL. 8632407
Relative potency (binding) = 1.4 Potency of the compound relative to aminoglutethimide against Cytochrome P450 19A1. ChEMBL. 8632407
Relative potency (binding) = 1.4 Potency of the compound relative to aminoglutethimide against Cytochrome P450 19A1. ChEMBL. 8632407

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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