Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.8876 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.1014 | 0.0453 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.7379 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.7379 | 0.7362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0082 | 0.1363 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4722 | 0.4688 |
Onchocerca volvulus | 0.003 | 0.4439 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.4722 | 0.6015 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0.0064 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4439 | 0.4403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.7379 | 0.7362 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.1014 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.4439 | 0.5396 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0603 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.7379 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.4439 | 0.5381 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.7379 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4722 | 0.4688 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.7379 | 0.7362 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0191 | 0.0127 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.7379 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.7379 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0711 | 0.0651 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0064 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.7379 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.4722 | 0.6015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Animals dead (ADMET) | > 2 | Antifilarial activity against L. carinii infections in the Jird at dose 100 mg/kg administered subcutaneously; two or more animals died prematurely considered to be drug toxicity. | ChEMBL. | 6887202 |
Reduction of live worms (functional) | = 15 % | Antifilarial activity against L. carinii infections in the Jird at dose 3 mg/kg administered orally | ChEMBL. | 6887202 |
Reduction of live worms (functional) | = 78 % | Antifilarial activity against L. carinii infections in the Jird at dose 25 mg/kg administered orally | ChEMBL. | 6887202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.