Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Complex formation (functional) | = 0 % | Effect on cellular protein DNA complex formation(%) at 10 microM in comparison with etoposide | ChEMBL. | 1312600 |
IC50 (functional) | > 7.5 uM | Concentration required for 50% reduction in KB cell number after 3-day incubation | ChEMBL. | 1312600 |
ID50 (binding) | > 100 uM | Evaluated for the inhibition of human DNA Topoisomerase II | ChEMBL. | 1312600 |
ID50 (binding) | > 100 uM | Evaluated for the inhibition of human DNA Topoisomerase II | ChEMBL. | 1312600 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.