Detailed information for compound 289602

Basic information

Technical information
  • TDR Targets ID: 289602
  • Name: 3-[4-amino-7-[1-(2-hydroxyethyl)piperidin-4-y l]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
  • MW: 353.418 | Formula: C19H23N5O2
  • H donors: 3 H acceptors: 4 LogP: 1.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCC(CC1)n1cc(c2c1ncnc2N)c1cccc(c1)O
  • InChi: 1S/C19H23N5O2/c20-18-17-16(13-2-1-3-15(26)10-13)11-24(19(17)22-12-21-18)14-4-6-23(7-5-14)8-9-25/h1-3,10-12,14,25-26H,4-9H2,(H2,20,21,22)
  • InChiKey: WJSCDYSIDGEWEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-amino-7-[1-(2-hydroxyethyl)-4-piperidyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
  • 3-[4-amino-7-[1-(2-hydroxyethyl)-4-piperidinyl]-5-pyrrolo[2,3-d]pyrimidinyl]phenol
  • 3-[4-azanyl-7-[1-(2-hydroxyethyl)piperidin-4-yl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
  • 3-[4-amino-7-[1-(2-hydroxyethyl)piperidin-4-yl]pyrrolo[5,4-d]pyrimidin-5-yl]phenol
  • 3-[4-amino-7-[1-(2-hydroxyethyl)-4-piperidyl]pyrrolo[5,4-d]pyrimidin-5-yl]phenol
  • 3-[4-amino-7-[1-(2-hydroxyethyl)-4-piperidinyl]-5-pyrrolo[5,4-d]pyrimidinyl]phenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Gallus gallus Tyrosine-protein kinase SRC Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni tyrosine kinase Tyrosine-protein kinase SRC   533 aa 501 aa 35.3 %
Schistosoma mansoni serine/threonine protein kinase Tyrosine-protein kinase SRC   533 aa 473 aa 24.5 %
Echinococcus multilocularis tyrosine protein kinase Btk29A Tyrosine-protein kinase SRC   533 aa 500 aa 35.0 %
Onchocerca volvulus Tyrosine-protein kinase SRC   533 aa 435 aa 27.4 %
Echinococcus multilocularis tyrosine protein kinase Abl Tyrosine-protein kinase SRC   533 aa 506 aa 36.6 %
Brugia malayi Tyrosine-protein kinase abl-1 Tyrosine-protein kinase SRC   533 aa 455 aa 44.4 %
Onchocerca volvulus Cyclin-H homolog Tyrosine-protein kinase SRC   533 aa 453 aa 44.8 %
Echinococcus granulosus c src tyrosine kinase Tyrosine-protein kinase SRC   533 aa 513 aa 33.7 %
Echinococcus granulosus tyrosine protein kinase ABL1 Tyrosine-protein kinase SRC   533 aa 473 aa 39.5 %
Echinococcus multilocularis tyrosine protein kinase ABL1 Tyrosine-protein kinase SRC   533 aa 473 aa 39.1 %
Echinococcus multilocularis c src tyrosine kinase Tyrosine-protein kinase SRC   533 aa 513 aa 33.9 %
Echinococcus granulosus tyrosine protein kinase Btk29A Tyrosine-protein kinase SRC   533 aa 500 aa 35.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0097 0.1065 0.0672
Echinococcus granulosus tyrosine protein kinase Lyn 0.011 0.1324 0.1324
Schistosoma mansoni gliotactin 0.0097 0.1065 0.1065
Echinococcus multilocularis epidermal growth factor receptor 0.0185 0.2725 0.2725
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0272 0.4366 0.4366
Echinococcus granulosus tyrosine protein kinase Blk 0.0094 0.1007 0.1007
Schistosoma mansoni tyrosine kinase 0.0096 0.1048 0.1048
Echinococcus multilocularis BC026374 protein (S09 family) 0.0097 0.1065 0.1065
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0062 0.0421 0.0421
Schistosoma mansoni tyrosine kinase 0.0102 0.1159 0.1159
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0094 0.1007 0.1007
Echinococcus granulosus epidermal growth factor receptor 0.0102 0.1159 0.1159
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0097 0.1065 0.1065
Brugia malayi Carboxylesterase family protein 0.0572 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1065 0.0672
Echinococcus granulosus para nitrobenzyl esterase 0.0097 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0097 0.1065 0.0672
Loa Loa (eye worm) hypothetical protein 0.0101 0.1149 0.076
Echinococcus multilocularis acetylcholinesterase 0.0572 1 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0097 0.1065 0.1065
Loa Loa (eye worm) TK/ABL protein kinase 0.0272 0.4366 0.4118
Schistosoma mansoni neuroligin 3 (S09 family) 0.0097 0.1065 0.1065
Echinococcus granulosus carboxylesterase 5A 0.0572 1 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0185 0.2725 0.2405
Entamoeba histolytica protein kinase, putative 0.0076 0.0683 0.5
Loa Loa (eye worm) hypothetical protein 0.0572 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.011 0.1324 0.1324
Brugia malayi Tyrosine-protein kinase abl-1 0.0135 0.1791 0.1429
Onchocerca volvulus 0.0097 0.1065 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 0.1324 0.1324
Loa Loa (eye worm) carboxylesterase 0.0097 0.1065 0.0672
Echinococcus multilocularis carboxylesterase 5A 0.0572 1 1
Echinococcus granulosus acetylcholinesterase 0.0572 1 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0097 0.1065 0.5
Brugia malayi Carboxylesterase family protein 0.0097 0.1065 0.0672
Loa Loa (eye worm) hypothetical protein 0.0097 0.1065 0.0672
Echinococcus multilocularis tyrosine protein kinase Src64B 0.011 0.1324 0.1324
Loa Loa (eye worm) carboxylesterase 0.0097 0.1065 0.0672
Schistosoma mansoni BC026374 protein (S09 family) 0.0097 0.1065 0.1065
Schistosoma mansoni tyrosine kinase 0.0096 0.1048 0.1048
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0088 0.0897 0.0897
Echinococcus granulosus tyrosine protein kinase ABL1 0.0272 0.4366 0.4366
Schistosoma mansoni tyrosine kinase 0.0255 0.4042 0.4042
Brugia malayi Carboxylesterase family protein 0.0097 0.1065 0.0672
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.2141 0.1795
Echinococcus granulosus tyrosine protein kinase HCK 0.0076 0.0683 0.0683
Schistosoma mansoni tyrosine kinase 0.011 0.1324 0.1324
Schistosoma mansoni tyrosine kinase 0.0102 0.1159 0.1159
Echinococcus multilocularis tyrosine protein kinase Fgr 0.011 0.1324 0.1324
Onchocerca volvulus 0.0097 0.1065 0.5
Onchocerca volvulus 0.0097 0.1065 0.5
Brugia malayi hypothetical protein 0.0097 0.1065 0.0672
Brugia malayi Carboxylesterase family protein 0.0097 0.1065 0.0672
Onchocerca volvulus 0.0097 0.1065 0.5
Echinococcus granulosus BC026374 protein S09 family 0.0097 0.1065 0.1065
Echinococcus granulosus tyrosine protein kinase Fyn 0.011 0.1324 0.1324
Echinococcus multilocularis tyrosine protein kinase Abl 0.0135 0.1791 0.1791
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 0.1324 0.1324
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 0.1324 0.1324
Echinococcus multilocularis acetylcholinesterase 0.0572 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.011 0.1324 0.1324
Brugia malayi Furin-like cysteine rich region family protein 0.0185 0.2725 0.2405
Loa Loa (eye worm) acetylcholinesterase 1 0.0572 1 1
Echinococcus granulosus insulin receptor 0.0062 0.0421 0.0421
Mycobacterium ulcerans carboxylesterase, LipT 0.0097 0.1065 0.5
Echinococcus granulosus neuroligin 0.0097 0.1065 0.1065
Echinococcus multilocularis neuroligin 0.0097 0.1065 0.1065
Echinococcus multilocularis epidermal growth factor receptor 0.0102 0.1159 0.1159
Echinococcus multilocularis 0.0056 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0572 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0062 0.0421 0.0421
Schistosoma mansoni tyrosine kinase 0.0096 0.1048 0.1048
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.011 0.1324 0.1324
Echinococcus granulosus acetylcholinesterase 0.0572 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.011 0.1324 0.1324
Loa Loa (eye worm) carboxylesterase 0.0572 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0097 0.1065 0.1065
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.011 0.1324 0.1324
Echinococcus multilocularis insulin receptor 0.0062 0.0421 0.0421
Loa Loa (eye worm) TK protein kinase 0.0094 0.1007 0.0612
Brugia malayi protein-tyrosine kinase 0.0094 0.1007 0.0612
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0097 0.1065 0.1065
Loa Loa (eye worm) SRC-1 0.011 0.1324 0.0942
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.011 0.1324 0.1324
Trichomonas vaginalis spcc417.12 protein, putative 0.0097 0.1065 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0097 0.1065 0.1065
Echinococcus granulosus tyrosine kinase 0.0094 0.1007 0.1007
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0097 0.1065 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.1065 0.0672
Brugia malayi SRC-1 0.011 0.1324 0.0942
Brugia malayi Carboxylesterase family protein 0.0097 0.1065 0.0672
Schistosoma mansoni tyrosine kinase 0.0185 0.2725 0.2725
Onchocerca volvulus 0.0097 0.1065 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.1065 0.0672
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.011 0.1324 0.1324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0572 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1065 0.0672
Echinococcus multilocularis tyrosine protein kinase Srms 0.0094 0.1007 0.1007
Echinococcus multilocularis tyrosine protein kinase Blk 0.0094 0.1007 0.1007
Schistosoma mansoni tyrosine kinase 0.0062 0.0421 0.0421
Echinococcus granulosus tyrosine protein kinase Fyn 0.011 0.1324 0.1324
Schistosoma mansoni tyrosine kinase 0.011 0.1324 0.1324
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0102 0.1159 0.1159
Loa Loa (eye worm) TK protein kinase 0.0076 0.0683 0.0273
Schistosoma mansoni acetylcholinesterase 0.0097 0.1065 0.1065
Mycobacterium tuberculosis Carboxylesterase LipT 0.0097 0.1065 0.5
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0097 0.1065 0.5
Schistosoma mansoni tyrosine kinase 0.0062 0.0421 0.0421
Echinococcus granulosus epidermal growth factor receptor 0.0185 0.2725 0.2725
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0094 0.1007 0.1007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0097 0.1065 0.1065
Echinococcus multilocularis tyrosine protein kinase HCK 0.0076 0.0683 0.0683
Echinococcus granulosus tyrosine protein kinase Fyn 0.011 0.1324 0.1324
Echinococcus granulosus tyrosine protein kinase Src42A 0.0088 0.0897 0.0897
Echinococcus multilocularis tyrosine protein kinase Src42A 0.011 0.1324 0.1324

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9 Inhibition of c-Src ChEMBL. 18722033
IC50 (binding) = 0.001 uM Inhibition of p60 c-Src tyrosine kinase ChEMBL. 11277536
IC50 (binding) = 0.001 uM Inhibition of p60 c-Src tyrosine kinase ChEMBL. 11277536
IC50 (binding) = 0.098 uM Concentration required for inhibition of v-Abl receptor by tyrosine kinase enzyme assay ChEMBL. 11277536
IC50 (binding) = 0.098 uM Concentration required for inhibition of v-Abl receptor by tyrosine kinase enzyme assay ChEMBL. 11277536
IC50 (binding) = 0.36 uM Tested for inhibitory activity against Epidermal growth factor receptor ChEMBL. 11277536
IC50 (binding) = 0.36 uM Tested for inhibitory activity against Epidermal growth factor receptor ChEMBL. 11277536
IC50 (functional) = 0.6 uM Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assay ChEMBL. 11277536
IC50 (functional) = 0.6 uM Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assay ChEMBL. 11277536
IC50 (binding) = 2.54 uM Concentration required for inhibition of epidermal growth factor receptor (EGF-R) by tyrosine kinase enzyme activity ChEMBL. 11277536
IC50 (binding) = 2.54 uM Concentration required for inhibition of epidermal growth factor receptor (EGF-R) by tyrosine kinase enzyme activity ChEMBL. 11277536
IC50 (functional) > 10 uM Inhibition of autophosphorylation of epidermal growth factor receptor (EGF-R) in a cellular assay ChEMBL. 11277536
IC50 (functional) > 10 uM Inhibition of autophosphorylation of epidermal growth factor receptor (EGF-R) in a cellular assay ChEMBL. 11277536

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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