Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0152 | 0.5422 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0068 | 0.1295 | 0.2388 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0152 | 0.5422 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0152 | 0.5422 | 0.5422 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0152 | 0.5422 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0068 | 0.1295 | 0.1295 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0152 | 0.5422 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0933 | 0.0933 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0152 | 0.5422 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.7985 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0152 | 0.5422 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0152 | 0.5422 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0152 | 0.5422 | 0.5422 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0152 | 0.5422 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0152 | 0.5422 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0152 | 0.5422 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0152 | 0.5422 | 0.5 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0152 | 0.5422 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0933 | 0.0933 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0068 | 0.1295 | 0.2388 |
Echinococcus granulosus | proteasome prosome macropain | 0.0152 | 0.5422 | 0.6169 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0152 | 0.5422 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0068 | 0.1295 | 0.1295 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0152 | 0.5422 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.7985 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0152 | 0.5422 | 0.6169 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.2 nM | Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells | ChEMBL. | 10072681 |
Ki (binding) | = 2.2 nM | Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells | ChEMBL. | 10072681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.