Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0052 | 0.29 | 0.2806 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Echinococcus granulosus | lamin | 0.0031 | 0.1274 | 0.2772 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.1274 | 0.2772 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0052 | 0.29 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0574 | 0.1249 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.0574 | 0.1249 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4597 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.1274 | 0.1741 |
Leishmania major | DNA polymerase eta, putative | 0.0036 | 0.1685 | 0.4775 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0574 | 0.1249 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.1274 | 0.1274 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Echinococcus multilocularis | musashi | 0.0031 | 0.1274 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4597 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.1274 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.29 | 0.29 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.0574 | 0.1249 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.4597 | 0.4525 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.0574 | 0.1904 |
Schistosoma mansoni | lamin | 0.0031 | 0.1274 | 0.1741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0574 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.1274 | 0.1159 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0574 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.0574 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0574 | 0.1904 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4597 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.0574 | 0.0574 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0036 | 0.1685 | 0.4775 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.4597 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4597 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0036 | 0.1685 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.4597 | 0.4597 |
Echinococcus multilocularis | lamin | 0.0031 | 0.1274 | 0.2772 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.0574 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1229 | 0.1229 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0052 | 0.29 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0052 | 0.29 | 0.5783 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0574 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.0574 | 0.5 |
Brugia malayi | RNA binding protein | 0.0073 | 0.4597 | 0.4525 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0574 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.1274 | 0.1274 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0574 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.1274 | 0.1159 |
Echinococcus multilocularis | dna polymerase eta | 0.0052 | 0.29 | 0.631 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0574 | 0.0449 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0052 | 0.29 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1274 | 0.1274 |
Schistosoma mansoni | lamin | 0.0031 | 0.1274 | 0.1741 |
Echinococcus granulosus | dna polymerase eta | 0.0052 | 0.29 | 0.631 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4597 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.4597 | 0.4525 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.4597 | 0.4597 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.4597 | 0.4597 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.1274 | 0.2772 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0131 | 0.0131 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.0574 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0574 | 0.1904 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.4597 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0574 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 84 % | In vitro inhibition of IL-1beta (interleukin-1beta) induced degradation of bovine nasal cartilage in an organ culture assay at 30 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.