Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0824 | 0.8821 | 0.8821 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.0891 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0139 | 0.0883 | 0.0883 |
Echinococcus granulosus | carboxylesterase 5A | 0.0824 | 0.8821 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0139 | 0.0883 | 0.1287 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0139 | 0.0883 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0139 | 0.0883 | 0.1001 |
Echinococcus granulosus | neuroligin | 0.0139 | 0.0883 | 0.1001 |
Leishmania major | hypothetical protein, conserved | 0.0082 | 0.0222 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.0883 | 0.0769 |
Onchocerca volvulus | 0.0139 | 0.0883 | 0.9891 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0139 | 0.0883 | 0.1001 |
Echinococcus granulosus | acetylcholinesterase | 0.0824 | 0.8821 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.0891 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0139 | 0.0883 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.0222 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0082 | 0.0222 | 0.0252 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0139 | 0.0883 | 0.1001 |
Mycobacterium leprae | Probable lipase LipE | 0.0082 | 0.0222 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0082 | 0.0222 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0824 | 0.8821 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0824 | 0.8821 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0139 | 0.0883 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Loa Loa (eye worm) | carboxylesterase | 0.0139 | 0.0883 | 0.0769 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0824 | 0.8821 | 1 |
Onchocerca volvulus | 0.0139 | 0.0883 | 0.9891 | |
Loa Loa (eye worm) | hypothetical protein | 0.0824 | 0.8821 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0525 | 0.5357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0824 | 0.8821 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0139 | 0.0883 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0824 | 0.8821 | 0.8821 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0139 | 0.0883 | 0.1287 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0139 | 0.0883 | 0.1001 |
Schistosoma mansoni | acetylcholinesterase | 0.0139 | 0.0883 | 0.1001 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.0883 | 0.0769 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0082 | 0.0222 | 0.0252 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0891 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0891 | 0.0777 |
Onchocerca volvulus | 0.0139 | 0.0883 | 0.9891 | |
Onchocerca volvulus | 0.0139 | 0.0883 | 0.9891 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0139 | 0.0883 | 0.1001 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0082 | 0.0222 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.0883 | 0.0769 |
Loa Loa (eye worm) | carboxylesterase | 0.0139 | 0.0883 | 0.0769 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0139 | 0.0883 | 0.0883 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0824 | 0.8821 | 1 |
Brugia malayi | hypothetical protein | 0.014 | 0.0891 | 0.0777 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0139 | 0.0883 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0139 | 0.0883 | 0.0883 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0139 | 0.0883 | 0.1001 |
Mycobacterium leprae | conserved hypothetical protein | 0.0082 | 0.0222 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0082 | 0.0222 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.0883 | 0.0769 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0139 | 0.0883 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0082 | 0.0222 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.0824 | 0.8821 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0824 | 0.8821 | 0.8821 |
Brugia malayi | hypothetical protein | 0.0139 | 0.0883 | 0.0769 |
Echinococcus multilocularis | neuroligin | 0.0139 | 0.0883 | 0.0883 |
Echinococcus granulosus | acetylcholinesterase | 0.0824 | 0.8821 | 1 |
Onchocerca volvulus | 0.0139 | 0.0883 | 0.9891 | |
Schistosoma mansoni | gliotactin | 0.0139 | 0.0883 | 0.1001 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0082 | 0.0222 | 0.0252 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.0222 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 2.8 | Ratio of mean % dose/g of brain to that of blood in rats at 5 minutes | ChEMBL. | 8421292 |
Activity (ADMET) | = 3.7 | Ratio of mean % dose/g of brain to that of blood in rats at 30 minutes | ChEMBL. | 8421292 |
Uptake (ADMET) | = 0.57 % | Brain uptake of [99mTc] complexes was evaluated in pentobarbital-anesthetized female Sprague-Dawley rats at 30 minutes, expressed as percent dose/g | ChEMBL. | 8421292 |
Uptake (ADMET) | = 0.64 % | Brain uptake of [99mTc] complexes was evaluated in pentobarbital-anesthetized female Sprague-Dawley rats at 5 minutes, expressed as percent dose/g | ChEMBL. | 8421292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.