Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0199 | 0.7264 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0123 | 0.2764 | 0.2407 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0176 | 0.5926 | 0.8159 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0199 | 0.7264 | 0.9366 |
Brugia malayi | flavodoxin family protein | 0.0199 | 0.7264 | 0.7264 |
Brugia malayi | FAD binding domain containing protein | 0.0199 | 0.7264 | 0.7264 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.7568 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0123 | 0.2764 | 0.2764 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0199 | 0.7264 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0199 | 0.7264 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0199 | 0.7264 | 0.9366 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0199 | 0.7264 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0199 | 0.7264 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0176 | 0.5926 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0176 | 0.5926 | 0.8159 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0199 | 0.7264 | 0.7264 |
Trypanosoma cruzi | p450 reductase, putative | 0.0199 | 0.7264 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0199 | 0.7264 | 0.9366 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0099 | 0.1337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0099 | 0.1337 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0199 | 0.7264 | 0.9366 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.7568 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0199 | 0.7264 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0199 | 0.7264 | 1 |
Treponema pallidum | flavodoxin | 0.0076 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0123 | 0.2764 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0199 | 0.7264 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0199 | 0.7264 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0176 | 0.5926 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0176 | 0.5926 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0199 | 0.7264 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.01 | 0.1427 | 0.0151 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0199 | 0.7264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7264 | 0.7264 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0123 | 0.2764 | 0.2764 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0199 | 0.7264 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0199 | 0.7264 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0199 | 0.7264 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 10.5 nM | Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells | ChEMBL. | 10072681 |
Ki (binding) | = 10.5 nM | Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells | ChEMBL. | 10072681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.