Detailed information for compound 289731

Basic information

Technical information
  • TDR Targets ID: 289731
  • Name: [5-tert-butyl-4-[[2-cyclohexyl-6-hydroxy-2-[2 -(4-hydroxyphenyl)ethyl]-4-oxo-3H-pyran-5-yl] sulfanyl]-2-methylphenyl] 4-fluorobenzenesulf onate
  • MW: 668.835 | Formula: C36H41FO7S2
  • H donors: 2 H acceptors: 5 LogP: 9.54 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc(cc1)CCC1(CC(=O)C(=C(O1)O)Sc1cc(C)c(cc1C(C)(C)C)OS(=O)(=O)c1ccc(cc1)F)C1CCCCC1
  • InChi: 1S/C36H41FO7S2/c1-23-20-32(29(35(2,3)4)21-31(23)44-46(41,42)28-16-12-26(37)13-17-28)45-33-30(39)22-36(43-34(33)40,25-8-6-5-7-9-25)19-18-24-10-14-27(38)15-11-24/h10-17,20-21,25,38,40H,5-9,18-19,22H2,1-4H3
  • InChiKey: VEYNVXDUDSWBKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-tert-butyl-4-[[2-cyclohexyl-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-4-oxo-3H-pyran-5-yl]sulfanyl]-2-methyl-phenyl] 4-fluorobenzenesulfonate
  • 4-fluorobenzenesulfonic acid [5-tert-butyl-4-[[2-cyclohexyl-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-4-oxo-3H-pyran-5-yl]thio]-2-methylphenyl] ester
  • 4-fluorobenzenesulfonic acid [5-tert-butyl-4-[[2-cyclohexyl-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-4-keto-3H-pyran-5-yl]thio]-2-methyl-phenyl] ester
  • [5-tert-butyl-4-[[6-cyclohexyl-2-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-4-oxo-5H-pyran-3-yl]sulfanyl]-2-methylphenyl] 4-fluorobenzenesulfonate
  • [5-tert-butyl-4-[[6-cyclohexyl-2-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-4-oxo-5H-pyran-3-yl]sulfanyl]-2-methyl-phenyl] 4-fluorobenzenesulfonate
  • 4-fluorobenzenesulfonic acid [5-tert-butyl-4-[[6-cyclohexyl-2-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-4-oxo-5H-pyran-3-yl]thio]-2-methylphenyl] ester
  • 4-fluorobenzenesulfonic acid [5-tert-butyl-4-[[6-cyclohexyl-2-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-4-keto-5H-pyran-3-yl]thio]-2-methyl-phenyl] ester
  • 263842-93-9
  • (+/-)-Benzenesulfonic acid, 4-fluoro-, 4-[[6-cyclohexyl-5,6-dihydro-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-2-oxo-2H-pyran-3-yl]thio]-5-(1,1-dimethylethyl)-2-methylphenyl ester
  • Dihydropyran-2-one deriv. 49
  • (+-)-Benzenesulfonic acid, 4-fluoro-, 4-((6-cyclohexyl-5,6-dihydro-4-hydroxy-6-(2-(4-hydroxyphenyl)ethyl)-2-oxo-2H-pyran-3-yl)thio)-5-(1,1-dimethylethyl)-2-methylphenyl ester
  • AIDS089247
  • AIDS-089247

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Echinococcus multilocularis neuropeptide receptor A26 0.034 0.0901 0.09
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0016 0.0006 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0025 0.0044
Trypanosoma cruzi Heat shock protein 83, putative 0.0042 0.0079 0.0074
Echinococcus multilocularis neuropeptide s receptor 0.034 0.0901 0.09
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0073 0.0164 0.0164
Brugia malayi hypothetical protein 0.002 0.0018 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.054 0.054
Brugia malayi Glycosyl hydrolases family 31 protein 0.0135 0.0334 0.0334
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0011 0.001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0156 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.007 0.0156 0.0151
Brugia malayi Patched protein homolog 1 0.002 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0055
Echinococcus granulosus importin subunit beta 1 0.0043 0.008 0.0079
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0175 0.5938
Trichomonas vaginalis replication factor C large subunit, putative 0.0016 0.0006 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0091 0.0213 0.0209
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0016 0.0016
Schistosoma mansoni endoplasmin 0.0042 0.0079 0.0074
Entamoeba histolytica hypothetical protein 0.0089 0.0208 0.2283
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.02 0.02
Schistosoma mansoni heat shock protein 0.0042 0.0079 0.0074
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.3632 1 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0026 0.0032 0.0767
Schistosoma mansoni hypothetical protein 0.014 0.0347 0.0343
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0023 0.0025 0.0025
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0044 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0016 0.0016
Trypanosoma brucei heat shock protein 90, putative 0.0042 0.0079 0.0074
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0026 0.0032 0.0028
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0032 0.0048 0.0048
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.006 0.0126 0.3025
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0006 0.0004
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0024 0.002
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0011 0.001
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Brugia malayi hypothetical protein 0.002 0.0018 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0026 0.0032 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0006 0.0004
Echinococcus multilocularis lysosomal alpha glucosidase 0.0135 0.0334 0.0334
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Schistosoma mansoni nuclear hormone receptor 0.002 0.0016 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0111 0.0269 0.0265
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0024 0.0023
Leishmania major heat shock protein, putative 0.0028 0.0039 0.0035
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0026 0.0032 0.0028
Brugia malayi steroid hormone receptor 0.002 0.0016 0.0016
Brugia malayi Uncoordinated protein 44 0.0026 0.0034 0.0034
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0032 0.0048 0.0044
Schistosoma mansoni DNA ligase IV 0.0016 0.0006 0.0002
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0016 0.0006 0.0004
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0258 0.0674 0.0673
Brugia malayi DKFZp564C0469 protein 0.0016 0.0006 0.0006
Entamoeba histolytica Ran family GTPase 0.0032 0.0048 0.0496
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0024 0.0541
Schistosoma mansoni DNA polymerase eta 0.0018 0.0011 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Echinococcus multilocularis lamin dm0 0.0073 0.0164 0.0164
Echinococcus granulosus Ankyrin 0.0026 0.0034 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0016 0.0015
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0011 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0078 0.0074
Schistosoma mansoni alpha glucosidase 0.003 0.0044 0.004
Echinococcus granulosus nibrin 0.0016 0.0006 0.0005
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Loa Loa (eye worm) patched family protein 0.002 0.0018 0.0017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0156 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0016 0.0016
Toxoplasma gondii HEAT repeat-containing protein 0.0043 0.008 0.1879
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0026 0.0034 0.003
Toxoplasma gondii aldehyde dehydrogenase 0.0111 0.0269 0.6593
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0175 0.0171
Schistosoma mansoni ankyrin 23/unc44 0.0026 0.0034 0.003
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0024 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0175 0.1913
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0062 0.0057
Brugia malayi hypothetical protein 0.0016 0.0006 0.0006
Brugia malayi topoisomerase 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0078 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.02 0.02
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.006 0.0126 0.0122
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0121 0.2897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0016 0.0015
Schistosoma mansoni thyroid hormone receptor 0.002 0.0016 0.0012
Echinococcus granulosus lamin 0.0073 0.0164 0.0164
Brugia malayi CXXC zinc finger family protein 0.0042 0.0079 0.0079
Echinococcus multilocularis heat shock protein 90 0.0042 0.0079 0.0078
Echinococcus multilocularis netrin receptor unc 5 0.0026 0.0034 0.0033
Echinococcus granulosus sterol regulatory element binding protein 0.164 0.4495 0.4495
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.007 0.0156 0.0155
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0025 0.0044
Echinococcus multilocularis neutral alpha glucosidase AB 0.003 0.0044 0.0043
Mycobacterium tuberculosis Conserved protein 0.0023 0.0025 0.0566
Echinococcus multilocularis geminin 0.054 0.1455 0.1455
Echinococcus multilocularis cpg binding protein 0.0045 0.0085 0.0085
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0026 0.0034 0.0824
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.012 0.0292 0.0287
Schistosoma mansoni hypothetical protein 0.0053 0.0106 0.0102
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0026 0.0034 0.0033
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0024 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0046 0.0042
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0028 0.0039 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0269 0.0265
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3411 0.939 0.939
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Trypanosoma brucei importin beta-1 subunit, putative 0.0043 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0023
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0024 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0106 0.0106
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.007 0.0156 0.0325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0016 0.0015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0135 0.0334 0.0334
Onchocerca volvulus 0.0023 0.0025 0.0307
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0046 0.105
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0111 0.0269 0.0265
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0111 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0005
Trypanosoma brucei heat shock protein 90, putative 0.0042 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.007 0.0156 0.0155
Brugia malayi Cytochrome P450 family protein 0.0042 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0016 0.0016
Loa Loa (eye worm) heat shock protein 90 0.0042 0.0079 0.0078
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0026 0.0032 0.0767
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0026 0.0032 0.0767
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0021 0.0018 0.034
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0024 0.0541
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0087 0.02 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Onchocerca volvulus 0.0042 0.0079 0.1183
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0032 0.0693
Echinococcus granulosus death domain containing protein 0.0026 0.0034 0.0033
Onchocerca volvulus 0.002 0.0018 0.0193
Loa Loa (eye worm) RNA binding protein 0.0116 0.0281 0.0281
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0016 0.0015
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.007 0.0156 0.0151
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0024 0.0023
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.007 0.0156 0.0155
Echinococcus granulosus Niemann Pick C1 protein 0.0338 0.0895 0.0895
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0116 0.0281 0.0281
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0035 0.0059 0.0059
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0024 0.0221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0089 0.0208 0.0207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0024 0.0541
Echinococcus granulosus expressed conserved protein 0.0317 0.0838 0.0838
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0011 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0026 0.0032 0.0767
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0026 0.0032 0.0767
Brugia malayi intermediate filament protein 0.0073 0.0164 0.0164
Brugia malayi Endoplasmin precursor 0.0042 0.0079 0.0079
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0032 0.0048 0.11
Brugia malayi CHE-14 protein 0.164 0.4495 0.4495
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0175 0.1913
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0026 0.0034 0.0033
Toxoplasma gondii heat shock protein HSP90 0.0042 0.0079 0.185
Schistosoma mansoni survival motor neuron protein 0.012 0.0292 0.0287
Loa Loa (eye worm) hypothetical protein 0.0077 0.0175 0.0174
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0016 0.0006 0.0006
Brugia malayi hypothetical protein 0.002 0.0018 0.0018
Brugia malayi Patched related family protein 12 0.002 0.0018 0.0018
Mycobacterium leprae Probable lipase LipE 0.0023 0.0025 0.0663
Loa Loa (eye worm) hypothetical protein 0.0077 0.0175 0.0174
Echinococcus multilocularis survival motor neuron protein 1 0.0586 0.1581 0.1581
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0016 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0024
Loa Loa (eye worm) endoplasmin 0.0042 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0044 0.0085
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0085 0.0195 0.4749
Echinococcus granulosus dna polymerase eta 0.0018 0.0011 0.001
Mycobacterium ulcerans hypothetical protein 0.0023 0.0025 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.006 0.0127 0.1377
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0005
Toxoplasma gondii hypothetical protein 0.002 0.0018 0.0338
Onchocerca volvulus Huntingtin homolog 0.0113 0.0273 0.4345
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0011 0.0011
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0026 0.0034 0.003
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0029 0.0054
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0026 0.0032 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0023 0.0025 0.0024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0175 0.0171
Schistosoma mansoni hypothetical protein 0.0458 0.1227 0.1223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.02 0.0196
Loa Loa (eye worm) hypothetical protein 0.3632 1 1
Echinococcus granulosus intermediate filament protein 0.0073 0.0164 0.0164
Mycobacterium ulcerans heat shock protein 90 0.004 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0026 0.0032 0.0767
Echinococcus granulosus cpg binding protein 0.0045 0.0085 0.0085
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0079 0.0074
Echinococcus granulosus nuclear factor of activated T cells 5 0.0258 0.0674 0.0673
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0016 0.0015
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0024 0.002
Onchocerca volvulus 0.002 0.0016 0.0164
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0024 0.002
Toxoplasma gondii MAPEG family protein 0.0052 0.0106 0.2538
Mycobacterium ulcerans beta-lactamase 0.0023 0.0025 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0026 0.0032 0.0767
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0024 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0112 0.2967
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0026 0.0032 0.0767
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0106 0.0106
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0026 0.0034 0.003
Toxoplasma gondii isocitrate dehydrogenase 0.0026 0.0034 0.0745
Echinococcus multilocularis beta LACTamase domain containing family member 0.0023 0.0025 0.0024
Toxoplasma gondii ABC1 family protein 0.0023 0.0025 0.0511
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Echinococcus multilocularis 0.0026 0.0032 0.0032
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.3632 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0026 0.0034 0.0034
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0024 0.0631
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0024 0.0541
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0026 0.0032 0.0028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0011 0.0177
Loa Loa (eye worm) hypothetical protein 0.164 0.4495 0.4495
Trichomonas vaginalis heat shock protein, putative 0.004 0.0071 0.0144
Onchocerca volvulus 0.002 0.0018 0.0193
Schistosoma mansoni chromosome transmission fidelity factor 0.0016 0.0006 0.0002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0338 0.0895 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.003 0.0044 0.0987
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0024 0.002
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0021 0.0018 0.0421
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0106 0.0106
Loa Loa (eye worm) patched family protein 0.002 0.0018 0.0017
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.006 0.0126 0.1929
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0041 0.004
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0085 0.0195 0.0409
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0024 0.0631
Brugia malayi heat shock protein 90 0.0042 0.0079 0.0079
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0024 0.0541
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0078 0.0176 0.2726
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0044 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0016 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.003 0.0044 0.0043
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0078 0.0176 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Loa Loa (eye worm) patched family protein 0.002 0.0018 0.0017
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0024 0.002
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0026 0.0032 0.0028
Entamoeba histolytica hypothetical protein 0.0089 0.0208 0.2283
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0024 0.0541
Brugia malayi RNA, U transporter 1 0.0122 0.0298 0.0298
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0026 0.0034 0.003
Echinococcus granulosus heat shock protein 0.0042 0.0079 0.0078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0035 0.0057 0.0114
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0011 0.0006
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0028 0.0039 0.0393
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.006 0.0126 0.3025
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Leishmania major GTP-binding protein, putative 0.0032 0.0048 0.0044
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.006 0.0126 0.3025
Echinococcus multilocularis snurportin 1 0.0458 0.1227 0.1227
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0111 0.0269 0.0269
Brugia malayi hypothetical protein 0.0586 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0005
Echinococcus multilocularis heat shock protein 0.0042 0.0079 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0033
Plasmodium vivax heat shock protein 90, putative 0.0028 0.0039 0.087
Schistosoma mansoni cytochrome P450 0.0026 0.0032 0.0028
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0729 0.0725
Onchocerca volvulus Netrin receptor homolog 0.0026 0.0034 0.0458
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.004 0.0071 0.1849
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0016 0.0006 0.0002
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0028 0.0039 0.0541
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Echinococcus multilocularis protein dispatched 1 0.1661 0.4551 0.4551
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0085 0.0195 0.0409
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Echinococcus multilocularis endoplasmin 0.004 0.0071 0.0071
Toxoplasma gondii ATPase, AAA family protein 0.0016 0.0006 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0026 0.0032 0.0767
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0026 0.0032 0.0028
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0026 0.0032 0.0767
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.007 0.0156 0.0325
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0089 0.0208 0.0207
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0025 0.0021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0016 0.0012
Mycobacterium tuberculosis Conserved protein 0.0023 0.0025 0.0566
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0025 0.0044
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0078 0.0176 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0016 0.0016
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0024 0.002
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Brugia malayi Niemann-Pick C1 protein precursor 0.0338 0.0895 0.0895
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0024 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Echinococcus multilocularis Ankyrin 0.0026 0.0034 0.0034
Loa Loa (eye worm) CXXC zinc finger family protein 0.0042 0.0079 0.0078
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0085 0.0195 0.0409
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0026 0.0034 0.003
Brugia malayi Cytochrome P450 family protein 0.0026 0.0032 0.0032
Schistosoma mansoni topbp1 0.0016 0.0006 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0023 0.0025 0.0566
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0035 0.0059 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.3632 1 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0024 0.002
Leishmania major DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.006 0.0126 0.0125
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0016 0.0164
Mycobacterium tuberculosis Probable lipase LipD 0.0023 0.0025 0.0566
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0026 0.0032 0.0028
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0039 0.0069 0.2223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0016 0.0016
Trypanosoma cruzi FHA domain containing protein, putative 0.0016 0.0006 0.0002
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0026 0.0034 0.0033
Schistosoma mansoni importin beta-1 0.0043 0.008 0.0076
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0175 0.4693
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0044 0.0044
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0034 0.0034
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0023 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Leishmania major cytochrome p450-like protein 0.0026 0.0032 0.0028
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0024 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0016 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0052 0.0106 0.0106
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0016 0.0015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.006 0.0126 0.4219
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0046 0.0046
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0016 0.0015
Schistosoma mansoni cpg binding protein 0.0045 0.0085 0.0081
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0078 0.0176 0.0175
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0026 0.0032 0.0028
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0016 0.0012
Plasmodium vivax SET domain protein, putative 0.0031 0.0046 0.105
Loa Loa (eye worm) intermediate filament protein 0.0073 0.0164 0.0164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0016 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0016 0.0012
Echinococcus granulosus GPCR family 2 0.0053 0.0106 0.0106
Brugia malayi Isocitrate dehydrogenase 0.0026 0.0034 0.0034
Onchocerca volvulus Huntingtin homolog 0.0113 0.0273 0.4345
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0024 0.002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0026 0.0034 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0026 0.0034 0.003
Brugia malayi Cytochrome P450 family protein 0.0077 0.0173 0.0173
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1704 0.4671 1
Brugia malayi beta-lactamase 0.0023 0.0025 0.0025
Brugia malayi beta-lactamase family protein 0.0023 0.0025 0.0025
Mycobacterium ulcerans lipase LipD 0.0023 0.0025 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0044 0.0085
Leishmania major importin beta-1 subunit, putative 0.0035 0.0057 0.0053
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.004 0.0071 0.5524
Plasmodium falciparum endoplasmin, putative 0.0031 0.0046 0.1049
Leishmania major cytochrome p450-like protein 0.0042 0.0078 0.0074
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0026 0.0032 0.0767
Brugia malayi Patched related family protein 10 0.002 0.0018 0.0018
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0016 0.0016
Schistosoma mansoni peptidase Clp (S14 family) 0.006 0.0126 0.0122
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0025 0.0663
Mycobacterium tuberculosis Conserved protein 0.0023 0.0025 0.0566
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1704 0.4671 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0273 0.0272
Echinococcus granulosus neutral alpha glucosidase AB 0.003 0.0044 0.0043
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0119 0.029 0.7871
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0044 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0027 0.0036 0.0867
Plasmodium falciparum importin beta, putative 0.0043 0.008 0.1879
Giardia lamblia Grp94/Hsp90 0.004 0.0071 0.0144
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Plasmodium falciparum heat shock protein 90, putative 0.0025 0.0029 0.0627
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0078 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0175 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0016 0.0016
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0016 0.0006 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0269 0.0265
Schistosoma mansoni intermediate filament proteins 0.0073 0.0164 0.016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0016 0.0016
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0039 0.0069 0.1786
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0016 0.0015
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0032 0.0048 0.0095
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.0011 0.0177
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0072 0.016 0.016
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Echinococcus granulosus Protein patched homolog 1 0.164 0.4495 0.4495
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0175 0.0171
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0015 0.0301
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.006 0.0126 1
Schistosoma mansoni transcription factor LCR-F1 0.0089 0.0208 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0011 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0016 0.0016
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Brugia malayi protein C24B5.3 0.002 0.0018 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0116 0.0281 0.0277
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0147 0.0367 1
Schistosoma mansoni hypothetical protein 0.0053 0.0106 0.0102
Schistosoma mansoni ran 0.0032 0.0048 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0025 0.0511
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0044 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0006 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0112 0.2967
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0025 0.0044
Brugia malayi RNA binding protein 0.0116 0.0281 0.0281
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0113 0.0273 0.0272
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0005
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.164 0.4495 0.4495
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Schistosoma mansoni cpg binding protein 0.0045 0.0085 0.0081
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.007 0.0156 0.0151
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0119 0.029 1
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0586 0.1581 0.1581
Schistosoma mansoni hypothetical protein 0.054 0.1455 0.1452
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0078 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0112 0.2967
Entamoeba histolytica heat shock protein 90, putative 0.0042 0.0079 0.0835
Loa Loa (eye worm) hypothetical protein 0.0166 0.042 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0046 0.0042
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0016 0.0006 0.0002
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0016 0.0006 0.0004
Loa Loa (eye worm) oxidoreductase 0.0023 0.0024 0.0023
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0044 0.0446
Brugia malayi hypothetical protein 0.0113 0.0273 0.0273
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0078 0.0176 0.0172
Onchocerca volvulus 0.002 0.0018 0.0193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0173 0.0172
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0078 0.0176 0.0175
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0085 0.0195 0.4749
Brugia malayi ecdysteroid receptor 0.002 0.0016 0.0016
Echinococcus granulosus heat shock protein 90 0.0036 0.0062 0.0061
Schistosoma mansoni microtubule-associated protein tau 0.3592 0.9889 0.9889
Brugia malayi isocitrate dehydrogenase 0.0026 0.0034 0.0034
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0244 0.0634 0.7075
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0026 0.0034 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.004 0.0071 0.2303
Schistosoma mansoni thyroid hormone receptor 0.002 0.0016 0.0012
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0011 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0106 0.0106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0046 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0018 0.034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0175 0.5938
Schistosoma mansoni hypothetical protein 0.0053 0.0106 0.0102
Onchocerca volvulus 0.002 0.0018 0.0193
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0024 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0046 0.0042
Mycobacterium ulcerans hypothetical protein 0.0077 0.0175 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0116 0.0281 0.0277
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0024 0.002
Plasmodium falciparum lipid/sterol:H+ symporter 0.002 0.0018 0.0338
Brugia malayi Muscleblind-like protein 0.015 0.0375 0.0375
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0023 0.0025 0.0566
Trichomonas vaginalis ran, putative 0.0032 0.0048 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0112 0.2967
Onchocerca volvulus 0.012 0.0292 0.465
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0026 0.0032 0.0767
Loa Loa (eye worm) hypothetical protein 0.0073 0.0164 0.0164
Onchocerca volvulus 0.0023 0.0024 0.0292
Schistosoma mansoni alpha-glucosidase 0.0116 0.0282 0.0278
Echinococcus multilocularis lamin 0.0073 0.0164 0.0164
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0011 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi cytochrome P450 0.0026 0.0032 0.0032
Brugia malayi glucose-6-phosphate dehydrogenase 0.0078 0.0176 0.0176
Echinococcus multilocularis expressed conserved protein 0.0317 0.0838 0.0838
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0024 0.002
Trichomonas vaginalis endoplasmin, putative 0.0031 0.0046 0.009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0178 0.0452 0.0452
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0032 0.0028
Schistosoma mansoni hypothetical protein 0.0113 0.0275 0.0271
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0026 0.0032 0.0028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0004 0.0004
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.3632 1 1
Trypanosoma cruzi heat shock protein, putative 0.0028 0.0039 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0011 0.0006
Echinococcus multilocularis muscleblind protein 0.015 0.0375 0.0375
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0175 0.0171
Echinococcus granulosus peptidase Clp S14 family 0.0039 0.0069 0.0069
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0024
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0026 0.0032 0.0028
Trypanosoma brucei Heat shock protein 83, putative 0.0042 0.0079 0.0074
Leishmania major alpha glucosidase II subunit, putative 0.003 0.0044 0.004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0032 0.0048 0.0048
Onchocerca volvulus 0.002 0.0018 0.0193
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0032 0.0048 0.0044
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0079 0.0074
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1704 0.4671 1
Loa Loa (eye worm) patched family protein 0.002 0.0018 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0004 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.042 0.042
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0024 0.0541
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Loa Loa (eye worm) patched family protein 0.002 0.0018 0.0017
Toxoplasma gondii patched family protein 0.002 0.0018 0.0338
Plasmodium vivax endoplasmin, putative 0.0042 0.0079 0.185
Giardia lamblia Fructose-bisphosphate aldolase 0.0244 0.0634 0.1351
Echinococcus granulosus neuropeptide s receptor 0.034 0.0901 0.09
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0024 0.0541
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0026 0.0032 0.0767
Echinococcus multilocularis heat shock protein 90 0.0036 0.0062 0.0061
Brugia malayi beta-lactamase family protein 0.0023 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.007 0.0156 0.17
Echinococcus granulosus FTZ F1 alpha 0.002 0.0016 0.0015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0016 0.0012
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0062 0.0057
Brugia malayi protein C24B5.3 0.002 0.0018 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0016 0.0015
Trypanosoma brucei importin beta-1 subunit, putative 0.0043 0.008 0.0076
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0025 0.003 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0026 0.0032 0.0767
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0026 0.0032 0.0028
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0039 0.0069 0.1786
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Schistosoma mansoni netrin receptor unc5 0.0026 0.0034 0.003
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Onchocerca volvulus Protein patched homolog 0.002 0.0018 0.0193
Brugia malayi Cytochrome P450 family protein 0.0042 0.0078 0.0078
Onchocerca volvulus 0.0238 0.062 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0051 0.0101 0.242
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0035 0.0057 0.0114
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0026 0.0032 0.0028
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0024 0.002
Schistosoma mansoni alpha-glucosidase 0.0116 0.0282 0.0278
Echinococcus multilocularis sterol regulatory element binding protein 0.164 0.4495 0.4495
Mycobacterium tuberculosis Probable lipase LipE 0.0023 0.0025 0.0566
Plasmodium vivax patched family protein, putative 0.002 0.0018 0.0338
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0016 0.0012
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0175 0.0171
Trichomonas vaginalis esterase, putative 0.0023 0.0025 0.0044
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0044 0.0085
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0051 0.0101 0.0097
Brugia malayi hypothetical protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.015 0.0375 0.0375
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0032 0.0028
Trichomonas vaginalis set domain proteins, putative 0.0238 0.062 0.132
Schistosoma mansoni heat shock protein 0.0042 0.0079 0.0074
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0032 0.0028
Trypanosoma brucei glucosidase, putative 0.003 0.0044 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0016 0.0012
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Echinococcus multilocularis ubiquitin specific protease 41 0.007 0.0156 0.0155
Entamoeba histolytica hypothetical protein 0.0016 0.0006 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0026 0.0032 0.0767
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0023 0.0025 0.0566
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0011 0.001
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0175 0.0175
Echinococcus granulosus netrin receptor unc 5 0.0026 0.0034 0.0033
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0026 0.0032 0.0028
Brugia malayi hypothetical protein 0.0089 0.0208 0.0208
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0016 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0116 0.0281 0.0277
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0175 0.0171
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Brugia malayi nuclear hormone receptor 0.002 0.0016 0.0016
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Loa Loa (eye worm) heat shock protein 75 0.0028 0.0039 0.0039
Onchocerca volvulus 0.0023 0.0024 0.0292
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0026 0.0032 0.0028
Schistosoma mansoni hypothetical protein 0.054 0.1455 0.1452
Onchocerca volvulus 0.0078 0.0177 0.2782
Leishmania major DNA polymerase eta, putative 0.0018 0.0011 0.0006
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0032 0.0919
Echinococcus granulosus ubiquitin specific protease 41 0.007 0.0156 0.0155
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0011 0.0006
Plasmodium vivax importin-beta 2, putative 0.0043 0.008 0.1879
Echinococcus granulosus geminin 0.054 0.1455 0.1455
Leishmania major cytochrome p450-like protein 0.0026 0.0032 0.0028
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Echinococcus granulosus tar DNA binding protein 0.0116 0.0281 0.0281
Mycobacterium tuberculosis Probable hydrolase 0.0023 0.0025 0.0566
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0026 0.0032 0.0767
Echinococcus granulosus endoplasmin 0.004 0.0071 0.0071
Brugia malayi nuclear receptor NHR-88 0.002 0.0016 0.0016
Entamoeba histolytica heat shock protein 90, putative 0.0042 0.0079 0.0835
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0016 0.0006 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.0079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0016 0.0164
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0024 0.0541
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0024 0.0024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0062 0.0123
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.006 0.0126 0.3025
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0024 0.002
Echinococcus multilocularis muscleblind protein 1 0.015 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0024 0.0541
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0016 0.0015
Giardia lamblia Heat shock protein HSP 90-alpha 0.0042 0.0079 0.0159
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.007 0.0156 0.0155
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0026 0.0032 0.0028
Toxoplasma gondii heat shock protein 90, putative 0.0042 0.0079 0.185
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0026 0.0032 0.0767
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0024 0.0024
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.006 0.0126 0.0125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0026 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.0126 0.0125
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0006 0.0002
Entamoeba histolytica hypothetical protein 0.0089 0.0208 0.2283
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Onchocerca volvulus 0.0031 0.0046 0.0659
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0175 0.1913
Echinococcus multilocularis microtubule associated protein 2 0.3592 0.9889 0.9889
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0028
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1704 0.4671 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0032 0.0048 0.11
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0079 0.0074
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0032 0.0048 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Trypanosoma brucei unspecified product 0.0018 0.0011 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.012 0.0292 0.0292
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0024 0.0042
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0026 0.0032 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0016 0.0016
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0244 0.0634 0.7075
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.007 0.0156 0.0155
Leishmania major hypothetical protein, conserved 0.0023 0.0025 0.0021
Echinococcus multilocularis nibrin 0.0016 0.0006 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.02 0.0196
Echinococcus granulosus snurportin 1 0.0458 0.1227 0.1227
Echinococcus multilocularis peptidase Clp (S14 family) 0.0039 0.0069 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0026 0.0032 0.0767
Giardia lamblia DINP protein human, muc B family 0.0018 0.0011 0.0014
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0085 0.0195 0.4749
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1838 0.5042 0.504
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0024
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.0596
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0032 0.0048 0.0044
Echinococcus multilocularis importin subunit beta 1 0.0043 0.008 0.0079
Echinococcus granulosus muscleblind protein 0.015 0.0375 0.0375
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0024 0.002
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.007 0.0156 0.0156
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Plasmodium vivax replication factor C subunit 1, putative 0.0016 0.0006 0.0043
Echinococcus granulosus lamin dm0 0.0073 0.0164 0.0164
Loa Loa (eye worm) beta-lactamase 0.0023 0.0025 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Plasmodium vivax heat shock protein, putative 0.0161 0.0406 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0016 0.0015
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.006 0.0126 0.7049
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Treponema pallidum fructose-bisphosphate aldolase 0.0244 0.0634 1
Toxoplasma gondii patched family protein 0.002 0.0018 0.0338
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0458 0.1227 0.1227
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.006 0.0126 0.0122
Echinococcus granulosus dna polymerase kappa 0.0018 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.014 0.0347 0.0343
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.006 0.0126 0.7049
Echinococcus multilocularis isocitrate dehydrogenase 0.0026 0.0034 0.0034
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0026 0.0032 0.0028
Toxoplasma gondii patched family protein 0.002 0.0018 0.0338
Schistosoma mansoni tar DNA-binding protein 0.0116 0.0281 0.0277
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0024 0.0489
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0024 0.002
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0078 0.0074
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0062 0.0123
Echinococcus multilocularis GPCR, family 2 0.0053 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0006 0.0004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0011 0.0006
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0026 0.0032 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Trypanosoma brucei heat shock protein, putative 0.0042 0.0079 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0011 0.0006
Brugia malayi Pre-SET motif family protein 0.021 0.054 0.054
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0024 0.0541
Plasmodium vivax heat shock protein 86, putative 0.0042 0.0079 0.185
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0026 0.0032 0.0767
Plasmodium falciparum heat shock protein 90, putative 0.0161 0.0406 1
Schistosoma mansoni hypothetical protein 0.0089 0.0208 0.0204
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0175 0.0171
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0011 0.0006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0035 0.0059 0.0059
Onchocerca volvulus 0.0073 0.0164 0.2578
Onchocerca volvulus 0.002 0.0018 0.0193
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0026 0.0032 0.0028
Echinococcus granulosus microsomal glutathione S transferase 3 0.0052 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.014 0.0347 0.0343
Loa Loa (eye worm) cytochrome P450 0.0026 0.0032 0.0032
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0024 0.002
Onchocerca volvulus 0.0077 0.0175 0.2747
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0106 0.0106
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0085 0.0195 0.0409
Entamoeba histolytica hypothetical protein 0.0089 0.0208 0.2283
Echinococcus multilocularis Niemann Pick C1 protein 0.0338 0.0895 0.0895
Onchocerca volvulus 0.0023 0.0024 0.0292
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.012
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.3632 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0032 0.0048 0.0048
Onchocerca volvulus 0.0073 0.0164 0.2578
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0016 0.0006 0.0004
Brugia malayi Pre-SET motif family protein 0.0031 0.0046 0.0046
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0121 0.6748
Loa Loa (eye worm) hypothetical protein 0.015 0.0375 0.0375
Trichomonas vaginalis importin beta-1, putative 0.0035 0.0057 0.0114
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0016 0.0006 0.0004
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0028 0.0039 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0269 0.0265
Onchocerca volvulus 0.0023 0.0024 0.0292
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0023 0.0024 0.0631
Echinococcus granulosus lysosomal alpha glucosidase 0.0135 0.0334 0.0334
Echinococcus granulosus Niemann Pick C1 protein 0.1978 0.5429 0.5429
Trichomonas vaginalis sucrase-isomaltase, putative 0.003 0.0044 0.0085
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0026 0.0034 0.0034
Echinococcus multilocularis musashi 0.0073 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0005
Brugia malayi Pax transcription activation domain interacting protein 0.0016 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0044 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0175 0.0171
Toxoplasma gondii patched family protein 0.002 0.0018 0.0338
Echinococcus granulosus neuropeptide receptor A26 0.034 0.0901 0.09
Brugia malayi TAR-binding protein 0.0116 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.006 0.0127 0.0126
Giardia lamblia Replication factor C, subunit 1 0.0016 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0023
Echinococcus granulosus replication factor c subunit 1 0.0016 0.0006 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0078 0.0078
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0011 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0025 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0025 0.0021
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Echinococcus multilocularis protein patched 0.164 0.4495 0.4495
Brugia malayi Intermediate filament tail domain containing protein 0.0073 0.0164 0.0164
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0024 0.002
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.004 0.0071 0.0067
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0026 0.0032 0.0028
Brugia malayi hypothetical protein 0.0233 0.0605 0.0605
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0175 0.0175
Toxoplasma gondii isocitrate dehydrogenase 0.0026 0.0034 0.0745
Schistosoma mansoni cpg binding protein 0.0042 0.0079 0.0074
Mycobacterium ulcerans esterase/lipase LipP 0.0023 0.0025 0.0021
Toxoplasma gondii Hsp90 domain-containing protein 0.0161 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.02 0.0196
Trypanosoma cruzi heat shock protein 90, putative 0.0018 0.001 0.0006
Brugia malayi Protein kinase domain containing protein 0.0026 0.0034 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0016 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0116 0.0281 0.0281
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0024 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0026 0.0034 0.0034
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0078 0.0176 0.0172
Echinococcus granulosus survival motor neuron protein 1 0.0586 0.1581 0.1581
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0044 0.0446
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0121 0.3207
Echinococcus multilocularis dna polymerase eta 0.0018 0.0011 0.001
Schistosoma mansoni lamin 0.0073 0.0164 0.016
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.006 0.0127 0.1377
Treponema pallidum heat shock protein 90 0.004 0.0071 0.1066
Trichomonas vaginalis conserved hypothetical protein 0.164 0.4495 0.9623
Toxoplasma gondii heat shock protein 75, putative 0.0028 0.0039 0.087
Schistosoma mansoni heat shock protein 0.0028 0.0039 0.0035
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0078 0.0176 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0024 0.002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0111 0.0269 0.7298
Loa Loa (eye worm) hypothetical protein 0.0233 0.0605 0.0605
Trichomonas vaginalis heat shock protein, putative 0.004 0.0071 0.0144
Leishmania major heat shock protein 83-1 0.0042 0.0079 0.0074
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0026 0.0034 0.0745
Echinococcus multilocularis tar DNA binding protein 0.0116 0.0281 0.0281
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0046 0.009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.0011 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.007 0.0156 0.0325
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0004 0.0004
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0024 0.002
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Schistosoma mansoni endoplasmin 0.0042 0.0079 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0016 0.0015
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0032 0.0048 0.11
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0044 0.004
Schistosoma mansoni coup transcription factor 0.002 0.0016 0.0012
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.4184 0.4182
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0024 0.002
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0119 0.029 0.0286
Loa Loa (eye worm) TAR-binding protein 0.0116 0.0281 0.0281
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0024 0.0489
Schistosoma mansoni microsomal glutathione s-transferase 0.0052 0.0106 0.0102
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0036 0.0062 0.0061
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.3632 1 1
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0175 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0116 0.0281 0.0277
Brugia malayi Death domain containing protein 0.0026 0.0034 0.0034
Echinococcus granulosus heat shock protein 90 0.0042 0.0079 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0156 0.0325
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0079 0.0159
Brugia malayi Patched related family protein 4 0.002 0.0018 0.0018
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0156 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0006 0.0004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0026 0.0034 0.0745
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0018 0.0217
Schistosoma mansoni hypothetical protein 0.0053 0.0106 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0175 0.4693
Onchocerca volvulus 0.002 0.0018 0.0193
Brugia malayi Importin beta-1 subunit 0.0043 0.008 0.008
Brugia malayi Probable ClpP-like protease 0.006 0.0126 0.0126
Toxoplasma gondii hypothetical protein 0.0021 0.0018 0.034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0106 0.0106
Schistosoma mansoni aldehyde dehydrogenase 0.0111 0.0269 0.0265
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0175 0.0171
Onchocerca volvulus Protein patched homolog 0.002 0.0018 0.0193
Echinococcus multilocularis Niemann Pick C1 protein 0.1978 0.5429 0.5429
Loa Loa (eye worm) hypothetical protein 0.0338 0.0895 0.0895
Brugia malayi Patched family protein 0.002 0.0018 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0077 0.0175 0.0174
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0016 0.0012
Onchocerca volvulus 0.0233 0.0605 0.9757
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.3632 1 1
Trypanosoma brucei heat shock protein 84, putative 0.0028 0.0039 0.0035
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0026 0.0032 0.0028
Schistosoma mansoni patched 1 0.164 0.4495 0.4493
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.02 0.02
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0025 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0016 0.0012
Echinococcus granulosus microtubule associated protein 2 0.3592 0.9889 0.9889
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0016 0.0016
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0229 0.0594 0.059
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0087 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.02 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0046 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0016 0.0012
Plasmodium falciparum replication factor C subunit 1, putative 0.0016 0.0006 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0016 0.0016
Onchocerca volvulus 0.0023 0.0025 0.0307
Brugia malayi hypothetical protein 0.002 0.0018 0.0018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0135 0.0334 0.0334
Echinococcus granulosus beta LACTamase domain containing family member 0.0023 0.0025 0.0024
Schistosoma mansoni ran 0.0032 0.0048 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.042 0.042
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0016 0.0006 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.042 0.0419
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0244 0.0634 0.1351
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0121 0.2897
Loa Loa (eye worm) hypothetical protein 0.0113 0.0275 0.0274
Mycobacterium tuberculosis Probable esterase LipL 0.0023 0.0025 0.0566
Schistosoma mansoni topbp1 0.0016 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0016 0.0015
Trypanosoma cruzi importin beta-1 subunit, putative 0.0035 0.0057 0.0053
Schistosoma mansoni lamin 0.0073 0.0164 0.016
Mycobacterium leprae putative cytochrome p450 0.0026 0.0032 0.0919
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0024 0.0489
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.014 0.0347 0.0343
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0039 0.007 0.0069
Onchocerca volvulus 0.0023 0.0025 0.0307
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0078 0.0176 0.0172
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.3632 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0026 0.0034 0.0034
Plasmodium falciparum heat shock protein 90 0.0042 0.0079 0.185
Echinococcus multilocularis replication factor c subunit 1 0.0016 0.0006 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0082 0.0187 0.4539
Loa Loa (eye worm) isocitrate dehydrogenase 0.0026 0.0034 0.0034
Brugia malayi Hsp90 protein 0.0028 0.0039 0.0039
Brugia malayi Myosin head containing protein 0.002 0.0018 0.0018
Treponema pallidum DNA ligase (lig) 0.0016 0.0006 0.0027
Brugia malayi cytoplasmic intermediate filament protein 0.0039 0.007 0.007
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0032 0.0028
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0078 0.0176 0.0172
Loa Loa (eye worm) hypothetical protein 0.0053 0.0106 0.0106

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 9.5 uM Effective concentration at which 50% of the HIV-IIIB-infected human lymphocyte-derived CEM cells protected from HIV-1 infection ChEMBL. 10715152
IC50 (binding) = 29 nM Activity of potent nonpeptidic inhibitor against protease ChEMBL. 10715152
IC50 (binding) = 29 nM Activity of potent nonpeptidic inhibitor against protease ChEMBL. 10715152
TC50 (ADMET) = 66 uM Concentration which elicits cytotoxicity in 50% of uninfected human lymphocyte derived CEM cells ChEMBL. 10715152
TC50 (ADMET) = 66 uM Concentration which elicits cytotoxicity in 50% of uninfected human lymphocyte derived CEM cells ChEMBL. 10715152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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