Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 97 % | The inhibitory activity was determined on L1210 mouse leukemia cell in presence of thymidine | ChEMBL. | 2231607 |
Control (functional) | = 97 % | The compound was tested in vitro for the inhibition of L1210 cell growth in the presence of thymidine | ChEMBL. | 1613755 |
Control (functional) | = 97 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
Control (functional) | = 97 % | The inhibitory activity was determined on L1210 mouse leukemia cell in presence of thymidine | ChEMBL. | 2231607 |
Control (functional) | = 97 % | The compound was tested in vitro for the inhibition of L1210 cell growth in the presence of thymidine | ChEMBL. | 1613755 |
Control (functional) | = 97 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
IC50 (binding) | = 7.7 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (binding) | = 0.02 uM | Concentration of the compound required to inhibit 50% activity of Thymidylate synthase was determined | ChEMBL. | 2231607 |
IC50 (binding) | = 0.02 uM | Inhibition of thymidylate synthase from L1210 cells | ChEMBL. | 1613755 |
IC50 (binding) | = 0.02 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (binding) | = 0.02 uM | Concentration of the compound required to inhibit 50% activity of Thymidylate synthase was determined | ChEMBL. | 2231607 |
IC50 (binding) | = 0.02 uM | Inhibition of thymidylate synthase from L1210 cells | ChEMBL. | 1613755 |
IC50 (binding) | = 0.02 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (functional) | = 0.027 uM | Concentration of the compound required to inhibit 50% growth of L1210 mouse leukemia cells was determined | ChEMBL. | 2231607 |
IC50 (functional) | = 0.027 uM | The compound was tested in vitro for the inhibition of L1210 cell growth in culture | ChEMBL. | 1613755 |
IC50 (functional) | = 0.027 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (functional) | = 0.027 uM | Concentration of the compound required to inhibit 50% growth of L1210 mouse leukemia cells was determined | ChEMBL. | 2231607 |
IC50 (functional) | = 0.027 uM | The compound was tested in vitro for the inhibition of L1210 cell growth in culture | ChEMBL. | 1613755 |
IC50 (functional) | = 0.027 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (functional) | = 0.11 uM | Concentration of the compound required to inhibit 50% growth of L1210 of R7A mutant mouse leukemia cell line was determined | ChEMBL. | 2231607 |
IC50 (functional) | = 0.11 uM | Concentration of the compound required to inhibit 50% growth of L1210 of R7A mutant mouse leukemia cell line was determined | ChEMBL. | 2231607 |
IC50 (functional) | = 2.2 uM | Concentration of the compound required to inhibit 50% growth of L1210 /1565 mutant mouse leukemia cell line was determined | ChEMBL. | 2231607 |
Ki (binding) | = 10.4 nM | Inhibition of thymidylate synthase, partially purified from L1210 mouse leukemia cells overexpressing TS | ChEMBL. | 1372358 |
Ki app (binding) | = 10.4 nM | Inhibition of thymidylate synthase, partially purified from L1210 mouse leukemia cells overexpressing TS | ChEMBL. | 1372358 |
Relative resistance (functional) | = 4 | Compound was tested for relative resistance to L1210 (R7A) cell line | ChEMBL. | 2231607 |
Relative resistance (functional) | = 81 | Compound was tested for relative resistance to L1210 (1565) cell line | ChEMBL. | 2231607 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 1613755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
5 literature references were collected for this gene.