Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Giardia lamblia | Histone deacetylase | 0.0413 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 8 | 0.0184 | 0.2567 | 0.2179 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0184 | 0.2567 | 0.2567 |
Brugia malayi | Histone deacetylase family protein | 0.0269 | 0.5331 | 0.5114 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0413 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0269 | 0.5331 | 0.4392 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0413 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0288 | 0.5937 | 0.512 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0413 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0184 | 0.2567 | 0.2179 |
Trypanosoma brucei | histone deacetylase 3 | 0.0269 | 0.5331 | 0.3719 |
Mycobacterium leprae | conserved hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0413 | 1 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0413 | 1 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0184 | 0.2567 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0269 | 0.5331 | 0.5087 |
Echinococcus granulosus | histone deacetylase 3 | 0.0413 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0269 | 0.5331 | 0.3719 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0413 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0269 | 0.5331 | 0.3719 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.059 | 0.059 |
Echinococcus multilocularis | histone deacetylase | 0.0269 | 0.5331 | 0.5087 |
Leishmania major | histone deacetylase, putative | 0.0413 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0413 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0413 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.024 | 0.4405 | 0.4405 |
Brugia malayi | Histone deacetylase family protein | 0.0269 | 0.5331 | 0.5114 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0156 | 0.1674 | 0.1286 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2567 | 0.2567 |
Echinococcus granulosus | histone deacetylase 7 | 0.0269 | 0.5331 | 0.5087 |
Entamoeba histolytica | histone deacetylase, putative | 0.0413 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0446 | 0.0446 |
Plasmodium falciparum | histone deacetylase 1 | 0.0413 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0413 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0413 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0184 | 0.2567 | 0.1073 |
Brugia malayi | histone deacetylase 11 | 0.0184 | 0.2567 | 0.2221 |
Echinococcus granulosus | histone deacetylase | 0.0269 | 0.5331 | 0.5087 |
Loa Loa (eye worm) | histone deacetylase | 0.0269 | 0.5331 | 0.5331 |
Trypanosoma brucei | histone deacetylase 1 | 0.0413 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Trypanosoma brucei | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0413 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0413 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0288 | 0.5937 | 0.5724 |
Trypanosoma brucei | histone deacetylase 4 | 0.0269 | 0.5331 | 0.3719 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0333 | 0.7412 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0413 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0184 | 0.2567 | 0.1073 |
Echinococcus granulosus | histone deacetylase 6 | 0.0288 | 0.5937 | 0.5724 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0413 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0269 | 0.5331 | 0.5331 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0269 | 0.5331 | 0.4392 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 5 mg kg-1 | Analgesic activity at 1 min following injection at 1 mg/kg into the lateral tail vein of the rat (55 degree centigrade hot plate assay) | ChEMBL. | 1847432 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.