Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.1961 | 0.128 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.5538 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4628 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1961 | 0.128 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.4628 | 0.4628 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.4628 | 0.4628 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.5538 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.3752 | 0.3223 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4628 | 0.4172 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.1961 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0015 | 0.0781 | 0.0781 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0035 | 0.4358 | 0.3879 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.5027 | 0.5027 |
Trypanosoma brucei | unspecified product | 0.0035 | 0.4358 | 0.3879 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.7443 | 0.7443 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.5538 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0015 | 0.0781 | 0.0781 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.1961 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0781 | 0.0781 |
Brugia malayi | polk-prov protein | 0.0032 | 0.3752 | 0.3752 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.1158 | 0.0408 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4628 | 0.4172 |
Brugia malayi | hypothetical protein | 0.0037 | 0.4628 | 0.4628 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.1961 | 0.128 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.5538 | 0.516 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0011 | 0.0176 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4628 | 0.4172 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.4628 | 0.4628 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3752 | 0.3752 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.5538 | 0.5538 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0015 | 0.0781 | 0.0781 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.5538 | 0.5538 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.5538 | 0.516 |
Schistosoma mansoni | DNA polymerase eta | 0.0015 | 0.0781 | 0.0781 |
Echinococcus granulosus | dna polymerase eta | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.1158 | 0.0408 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.5538 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.3752 | 0.3223 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.5027 | 0.5027 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.1158 | 0.0408 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.5538 | 0.516 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.4628 | 0.4628 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RLU/well (functional) | = 0.0000026 | Transfection activity of compound was tested in human cervical adenocarcinoma (HeLa) cells (Level of luciferase gene expression is expressed as mean of relative light units (RLU) per well) | ChEMBL. | 10853653 |
RLU/well (functional) | = 0.0000039 | Transfection activity of compound was tested in human embryonic kidney (293) cells (Level of luciferase gene expression is expressed as mean of relative light units (RLU) per well) | ChEMBL. | 10853653 |
RLU/well (functional) | = 0.000027 | Transfection activity of compound was tested in murine embryonic fibroblast (NIH3T3) cells (Level of luciferase gene expression is expressed as mean of relative light units (RLU) per well) | ChEMBL. | 10853653 |
RLU/well (functional) | = 0.00008 | Transfection activity of compound was tested in lewis lung carcinoma (3LL) cells (Level of luciferase gene expression is expressed as mean of relative light units (RLU) per well) | ChEMBL. | 10853653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.