Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.167 | 0.4601 | 1 |
Onchocerca volvulus | 0.006 | 0 | 0.5 | |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3561 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.167 | 0.4601 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1466 | 0.4016 | 0.4016 |
Echinococcus multilocularis | protein dispatched 1 | 0.1466 | 0.4016 | 0.4016 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.167 | 0.4601 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.167 | 0.4601 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1466 | 0.4016 | 0.4016 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0274 | 0.061 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1466 | 0.4016 | 0.4016 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3561 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3561 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3561 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.1466 | 0.4016 | 0.4016 |
Loa Loa (eye worm) | hypothetical protein | 0.3561 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3561 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3561 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.1466 | 0.4016 | 0.4016 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3561 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.006 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3561 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1466 | 0.4016 | 0.4016 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1466 | 0.4016 | 0.4016 |
Loa Loa (eye worm) | hypothetical protein | 0.1466 | 0.4016 | 0.4016 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1466 | 0.4016 | 0.4016 |
Brugia malayi | CHE-14 protein | 0.1466 | 0.4016 | 0.4016 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1466 | 0.4016 | 0.4016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.92 RFU min-1 | Nucleocapsid p7 protein (NCp7) zinc finger domain reactivity was measured by Trp37 fluorescence assay expressed as the average decrease in relative fluorescence units over 30 min | ChEMBL. | 9888834 |
EC50 (functional) | = 1 uM | Effective antiviral concentration against HIV-1 infected CEM-SS cells | ChEMBL. | 9888834 |
IC50 (functional) | = 81.5 uM | Antiviral activity against HIV-1 infected CEM-SS cells was determined in XTT cytoprotection assay | ChEMBL. | 9888834 |
TI (ADMET) | = 81.5 | Therapeutic index (EC50 / IC50) | ChEMBL. | 9888834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.