Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Xanthine dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | aldehyde oxidase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0041 | 0.0029 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0041 | 0.0029 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0299 | 0.5294 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0071 | 0.0627 | 0.5229 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0209 | 0.3458 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0041 | 0.0029 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0071 | 0.0627 | 0.3111 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0209 | 0.3458 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0062 | 0.0451 | 0.2238 |
Schistosoma mansoni | thyroid hormone receptor | 0.0299 | 0.5294 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0139 | 0.2015 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.051 | 0.9601 | 0.96 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0258 | 0.4448 | 0.8394 |
Schistosoma mansoni | thyroid hormone receptor | 0.0299 | 0.5294 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0508 | 0.9553 | 0.995 |
Onchocerca volvulus | 0.0041 | 0.0029 | 0.5 | |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0258 | 0.4448 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0099 | 0.1199 | 0.5951 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0099 | 0.1199 | 0.5951 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0209 | 0.3458 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0099 | 0.1199 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.051 | 0.9601 | 0.96 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.051 | 0.9601 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0258 | 0.4448 | 0.8394 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0071 | 0.0627 | 0.3111 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.