Detailed information for compound 290485

Basic information

Technical information
  • TDR Targets ID: 290485
  • Name: (4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy- 10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17- dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ]pentanoic acid
  • MW: 374.557 | Formula: C24H38O3
  • H donors: 2 H acceptors: 3 LogP: 5.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC(=O)O)C)C)C1)C
  • InChi: 1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h5,15,17-21,25H,4,6-14H2,1-3H3,(H,26,27)/t15-,17+,18+,19-,20+,21+,23+,24-/m1/s1
  • InChiKey: HIAJCGFYHIANNA-QIZZZRFXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid
  • 3 beta-hydroxy-delta 5-cholenic acid
  • 5255-17-4
  • 3beta-Hydroxy-5-cholenic acid
  • 3beta-Hydroxy-5-cholenoic acid
  • 3beta-Hydroxy-delta5-cholenic acid
  • 3beta-Hydroxychol-5-en-24-oic acid
  • 3beta-Hydroxy-chol-5-en-24-oic Acid
  • LMST04010201

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 1, group H, member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Bile acid receptor homolog Get druggable targets OG5_134445 All targets in OG5_134445
Brugia malayi ecdysteroid receptor Get druggable targets OG5_134445 All targets in OG5_134445
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134445 All targets in OG5_134445
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor nuclear receptor subfamily 1, group H, member 3 387 aa 321 aa 28.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0497 0.2729 0.4898
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.043
Echinococcus multilocularis thymidylate synthase 0.0112 0.056 0.0558
Brugia malayi glutaminase DH11.1 0.0292 0.1577 0.2828
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0066 0.0116
Mycobacterium tuberculosis Hypothetical protein 0.0053 0.023 0.0382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0066 0.0064
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0052 0.0104
Onchocerca volvulus 0.0024 0.0066 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Mycobacterium ulcerans beta-lactamase 0.0145 0.0746 0.1311
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0238
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0112 0.056 0.0815
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.009
Echinococcus multilocularis cpg binding protein 0.0091 0.0445 0.0443
Echinococcus multilocularis expressed conserved protein 0.0094 0.0461 0.0458
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0052 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.0063
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0052 0.0078
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0066 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0473 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.023 0.1231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0199 0.0197
Echinococcus granulosus p2X purinoceptor 4 0.0269 0.1447 0.2104
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.0063
Schistosoma mansoni hypothetical protein 0.0517 0.2847 0.4145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0066 0.0097
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0046 0.0052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0051 0.0071
Loa Loa (eye worm) dihydrofolate reductase 0.1 0.557 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0066 0.0116
Giardia lamblia DINP protein human, muc B family 0.0021 0.0046 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0066 0.0116
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0052 0.009
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0241 0.0403
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1 0.557 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.1209 0.2168
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0066 0.0116
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.01 0.0177
Echinococcus granulosus bloom syndrome protein 0.0048 0.0203 0.0293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0473 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0046 0.0044
Echinococcus granulosus lamin dm0 0.003 0.01 0.0143
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0018 0.0028
Echinococcus granulosus p2X purinoceptor 4 0.0269 0.1447 0.2104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0002 0.0003
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0081 0.0141
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0088 0.0429 0.0427
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0112 0.056 0.092
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0283 0.0412
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0066 0.0097
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0051 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0046 0.0079
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0018 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0473 0.0471
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0066 0.0097
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0104
Leishmania major mitochondrial DNA polymerase beta 0.0608 0.3359 1
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0046 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0066 0.0064
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0052 0.009
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0046 0.0108
Echinococcus granulosus p2X purinoceptor 4 0.0269 0.1447 0.2104
Schistosoma mansoni DNA helicase recq1 0.002 0.0043 0.0062
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0104
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0139 0.0218
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0104
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0052 0.005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0746 0.1336
Brugia malayi RNA binding protein 0.0133 0.0677 0.1212
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0056 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0608 0.3359 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.023 0.0635
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0043 0.0073
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0066 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0052 0.0112
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0066 0.0097
Brugia malayi nuclear hormone receptor 0.0024 0.0066 0.0116
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0417 0.0746
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0608 0.3359 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0043 0.0059
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0677 0.0675
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0043 0.0073
Schistosoma mansoni hypothetical protein 0.0048 0.0199 0.0289
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0347 0.0593
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0052 0.0063
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0043 0.017 0.0492
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0046 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0473 0.0685
Brugia malayi hypothetical protein 0.0053 0.023 0.0409
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0052 0.0063
Loa Loa (eye worm) hypothetical protein 0.0209 0.111 0.199
Loa Loa (eye worm) RecQ helicase 0.0048 0.0203 0.0361
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0046 0.0052
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0046 0.0038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0052 0.0063
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0088 0.0429 0.0427
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0473 0.0688
Schistosoma mansoni hypothetical protein 0.0088 0.0429 0.0625
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0088 0.0429 0.0622
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0066 0.0097
Echinococcus granulosus cpg binding protein 0.0091 0.0445 0.0645
Loa Loa (eye worm) hypothetical protein 0.0151 0.0779 0.1395
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0677 0.1212
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0052 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Leishmania major DNA polymerase eta, putative 0.0034 0.012 0.0305
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.0746 0.1311
Echinococcus multilocularis lamin 0.003 0.01 0.0098
Trichomonas vaginalis DNA helicase recq1, putative 0.0048 0.0203 0.1059
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0677 0.0986
Echinococcus multilocularis survival motor neuron protein 1 0.0497 0.2729 0.2728
Mycobacterium ulcerans hypothetical protein 0.032 0.1736 0.3095
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0283 0.0281
Loa Loa (eye worm) hypothetical protein 0.0145 0.0746 0.1336
Loa Loa (eye worm) hypothetical protein 0.0043 0.0172 0.0306
Schistosoma mansoni hypothetical protein 0.0517 0.2847 0.4145
Schistosoma mansoni lamin 0.003 0.01 0.0146
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0737 0.107
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0018 0.0022
Loa Loa (eye worm) RNA binding protein 0.0133 0.0677 0.1212
Echinococcus granulosus dna polymerase eta 0.0048 0.02 0.0288
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0052 0.0112
Leishmania major DNA polymerase eta, putative 0.0048 0.02 0.0545
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0066 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0746 0.2179
Brugia malayi beta-lactamase family protein 0.0145 0.0746 0.1336
Loa Loa (eye worm) inositol-1 0.0041 0.0163 0.029
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0212 0.0627
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.051 0.0913
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0412 0.12
Echinococcus multilocularis geminin 0.0517 0.2847 0.2845
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0116
Loa Loa (eye worm) hypothetical protein 0.0074 0.0347 0.0619
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0066 0.0064
Brugia malayi thymidylate synthase 0.0112 0.056 0.1002
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0347 0.0619
Schistosoma mansoni hypothetical protein 0.0077 0.0364 0.053
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0163 0.0436
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0163 0.261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0066 0.0116
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0066 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0066 0.0116
Brugia malayi Pax transcription factor protein 2 0.0237 0.1263 0.2265
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0046 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0046 0.0086
Mycobacterium ulcerans thymidylate synthase 0.0112 0.056 0.0977
Loa Loa (eye worm) hypothetical protein 0.0145 0.0746 0.1336
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0163 0.0436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0066 0.0116
Brugia malayi Cytochrome P450 family protein 0.0016 0.0018 0.0028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0081 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0066 0.0116
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0241 0.0723
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0046 0.0086
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0052 0.0063
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0163 0.0436
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0051 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0177
Brugia malayi Dihydrofolate reductase 0.1 0.557 1
Onchocerca volvulus 0.0145 0.0746 0.5726
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0238
Schistosoma mansoni survival motor neuron protein 0.0101 0.0501 0.073
Onchocerca volvulus 0.0101 0.0501 0.3705
Echinococcus granulosus thymidylate synthase 0.0112 0.056 0.0812
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0066 0.0064
Echinococcus multilocularis protein patched 0.0043 0.0172 0.017
Loa Loa (eye worm) hypothetical protein 0.0088 0.0429 0.0767
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.043
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0347 0.0985
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0746 0.4591
Leishmania major hypothetical protein, conserved 0.0145 0.0746 0.2179
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0076 0.0175
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0288 0.1553 0.4607
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0347 0.0985
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0288 0.1553 0.4595
Brugia malayi hypothetical protein 0.005 0.0212 0.0377
Trichomonas vaginalis DNA helicase recq, putative 0.0048 0.0203 0.1059
Brugia malayi MH2 domain containing protein 0.0116 0.0584 0.1045
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0066 0.0116
Schistosoma mansoni dihydrofolate reductase 0.1 0.557 0.811
Schistosoma mansoni hypothetical protein 0.0048 0.0199 0.0289
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0018 0.0028
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0052 0.0063
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0052 0.0104
Loa Loa (eye worm) hypothetical protein 0.0145 0.0746 0.1336
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0172 0.017
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0012 0.001
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0052 0.0112
Mycobacterium ulcerans glutaminase 0.0292 0.1577 0.2808
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0283 0.0478
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0052 0.0063
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0565 0.3115 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0066 0.0097
Brugia malayi hypothetical protein 0.0032 0.0112 0.0197
Mycobacterium ulcerans hypothetical protein 0.0074 0.0347 0.0593
Schistosoma mansoni blooms syndrome DNA helicase 0.0038 0.0146 0.0212
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0199 0.0286
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0501 0.0896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0224 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0066 0.0116
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0052 0.0104
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0112 0.056 0.0976
Entamoeba histolytica hypothetical protein 0.0077 0.0364 0.7076
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0088 0.0429 0.0625
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0041 0.00000000030262
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0172 0.0859
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0283 0.0478
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0052 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0066 0.0116
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0018 0.0016
Loa Loa (eye worm) pax transcription factor protein 2 0.0237 0.1263 0.2265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0347 0.0593
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0066 0.0094
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.0746 0.1311
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0347 0.0533
Schistosoma mansoni P2X receptor subunit 0.0269 0.1447 0.2106
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0347 0.0593
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0677 0.1212
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0018 0.0028
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0023
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0163 0.5
Loa Loa (eye worm) hypothetical protein 0.01 0.0495 0.0885
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0212 0.0602
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0163 0.08
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0021 0.0035
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0283 0.0794
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0066 0.0116
Echinococcus granulosus intermediate filament protein 0.003 0.01 0.0143
Echinococcus granulosus tar DNA binding protein 0.0133 0.0677 0.0983
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0584 0.1045
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0283 0.0412
Toxoplasma gondii ABC1 family protein 0.0145 0.0746 0.2351
Echinococcus multilocularis GPCR, family 2 0.0048 0.0199 0.0197
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0163 0.0161
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.012 0.0329
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0046 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0199 0.0353
Brugia malayi isocitrate dehydrogenase 0.0016 0.0018 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0199 0.0286
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0041 0.00000000030262
Brugia malayi Cytochrome P450 family protein 0.0016 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0048 0.0199 0.0353
Echinococcus multilocularis p2X purinoceptor 4 0.0269 0.1447 0.1445
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0081 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0041 0.00000000030262
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0172 0.0248
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0347 0.0533
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0066 0.0116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0364 0.0362
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0495 0.0493
Trichomonas vaginalis glutaminase, putative 0.0292 0.1577 1
Chlamydia trachomatis dihydrofolate reductase 0.1 0.557 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0013
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0052 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0677 0.0986
Onchocerca volvulus 0.0237 0.1263 1
Leishmania major hypothetical protein, conserved 0.005 0.0212 0.0581
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0473 0.0685
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0212 0.0627
Schistosoma mansoni lamin 0.003 0.01 0.0146
Brugia malayi hypothetical protein 0.0497 0.2729 0.4898
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0412 0.1181
Schistosoma mansoni cpg binding protein 0.0086 0.0417 0.0608
Loa Loa (eye worm) hypothetical protein 0.0145 0.0746 0.1336
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0043 0.0081
Echinococcus granulosus lamin 0.003 0.01 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0066 0.0116
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0412 0.1181
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0565 0.3115 0.9269
Loa Loa (eye worm) intermediate filament protein 0.003 0.01 0.0177
Schistosoma mansoni P2X receptor subunit 0.0269 0.1447 0.2106
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0347 0.0593
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0046 0.0086
Schistosoma mansoni DNA helicase recq5 0.002 0.0043 0.0062
Schistosoma mansoni hypothetical protein 0.0103 0.051 0.0743
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0052 0.0135
Loa Loa (eye worm) hypothetical protein 0.0048 0.02 0.0355
Brugia malayi beta-lactamase family protein 0.0145 0.0746 0.1336
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0066 0.0094
Onchocerca volvulus 0.0074 0.0347 0.243
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0046 0.0108
Entamoeba histolytica hypothetical protein 0.0077 0.0364 0.7076
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0504 0.0733
Trichomonas vaginalis esterase, putative 0.0145 0.0746 0.4591
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0043 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0116
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.0746 0.1311
Onchocerca volvulus Bile acid receptor homolog 0.0209 0.111 0.8736
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0163 0.0235
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0046 0.0079
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0199 0.0353
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0066 0.0094
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0163 0.08
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0079 0.0138
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0163 0.0471
Brugia malayi TAR-binding protein 0.0133 0.0677 0.1212
Trypanosoma brucei unspecified product 0.0021 0.0046 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0224 0.0372
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0018 0.0028
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0052 0.0112
Loa Loa (eye worm) hypothetical protein 0.005 0.0212 0.0377
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0746 0.4591
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0183 0.0963 0.1403
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0066 0.0097
Schistosoma mansoni glutaminase 0.0292 0.1577 0.2296
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.0746 0.1311
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0224 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0347 0.0619
Onchocerca volvulus 0.0145 0.0746 0.5726
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0172 0.0248
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0283 0.0409
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0066 0.0094
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0066 0.0116
Schistosoma mansoni hypothetical protein 0.0101 0.0501 0.073
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0043 0.0041
Brugia malayi beta-lactamase 0.0145 0.0746 0.1336
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.012 0.0305
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0041 0.00000000030262
Schistosoma mansoni hypothetical protein 0.0088 0.0429 0.0625
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.0746 0.1311
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0046 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0066 0.0116
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0347 0.0593
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0565 0.3115 1
Schistosoma mansoni intermediate filament proteins 0.003 0.01 0.0146
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0288 0.1553 0.4595
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0746 0.1086
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0212 0.0581
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0126
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0347 0.0593
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0018 0.0016
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0347 0.6699
Schistosoma mansoni microtubule-associated protein tau 0.0737 0.4087 0.5951
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.0063
Loa Loa (eye worm) beta-lactamase 0.0145 0.0746 0.1336
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0584 0.1045
Brugia malayi steroid hormone receptor 0.0024 0.0066 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.009
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.02 0.0355
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0066 0.0094
Onchocerca volvulus 0.0145 0.0746 0.5726
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0347 0.0593
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1 0.557 1
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0066 0.0064
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0212 0.0627
Loa Loa (eye worm) hypothetical protein 0.0103 0.051 0.0913
Schistosoma mansoni P2X receptor subunit 0.0269 0.1447 0.2106
Schistosoma mansoni DNA polymerase eta 0.0048 0.02 0.0291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0473 0.0845
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0347 0.0593
Loa Loa (eye worm) thymidylate synthase 0.0112 0.056 0.1002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.043
Schistosoma mansoni hypothetical protein 0.0048 0.0199 0.0289
Loa Loa (eye worm) apoptosis regulator protein 0.0088 0.0429 0.0767
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0163 0.0263
Brugia malayi Bloom's syndrome protein homolog 0.0048 0.0203 0.0361
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0163 0.08
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.043
Echinococcus multilocularis dnaJ subfamily B 0.1231 0.6868 0.6868
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.0746 0.1336
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0364 0.053
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0043 0.0081
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0283 0.0478
Schistosoma mansoni inositol monophosphatase 0.0041 0.0163 0.0238
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0066 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.02 0.0545
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.0746 0.1311
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.0746 0.1311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0066 0.0116
Echinococcus granulosus geminin 0.0517 0.2847 0.4143
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0113 0.0307
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0283 0.0857
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Mycobacterium tuberculosis Conserved protein 0.0145 0.0746 0.1311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0116
Mycobacterium leprae Probable lipase LipE 0.0145 0.0746 0.1257
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0066 0.0116
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0677 0.1212
Schistosoma mansoni hypothetical protein 0.0088 0.0429 0.0625
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0224 0.0372
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0565 0.3115 0.9269
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0066 0.0064
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0052 0.009
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0052 0.009
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0212 0.0627
Loa Loa (eye worm) hypothetical protein 0.0074 0.0347 0.0619
Schistosoma mansoni cpg binding protein 0.0091 0.0445 0.0648
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0052 0.0126
Echinococcus granulosus survival motor neuron protein 1 0.0497 0.2729 0.3972
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0043 0.0081
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.0746 0.1311
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0088 0.0429 0.0622
Echinococcus multilocularis bloom syndrome protein 0.0048 0.0203 0.0201
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0066 0.0097
Loa Loa (eye worm) oxidoreductase 0.0022 0.0052 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0473 0.0845
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0052 0.0104
Echinococcus granulosus expressed conserved protein 0.0094 0.0461 0.0668
Echinococcus granulosus dnaJ subfamily B 0.1231 0.6868 1
Schistosoma mansoni inositol monophosphatase 0.0041 0.0163 0.0238
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0056 0.0079
Schistosoma mansoni coup transcription factor 0.0024 0.0066 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0746 0.2196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0041 0.00000000030262
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0066 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0347 0.0619
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0677 0.0986
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0746 0.4591
Echinococcus multilocularis protein dispatched 1 0.0049 0.0207 0.0205
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0746 0.4591
Brugia malayi ecdysteroid receptor 0.0209 0.111 0.199
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0116
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0746 0.4591
Toxoplasma gondii hypothetical protein 0.0098 0.0483 0.1503
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0052 0.0112
Mycobacterium ulcerans lipase LipD 0.0145 0.0746 0.1311
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0495 1
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1 0.557 1
Schistosoma mansoni hypothetical protein 0.0022 0.0056 0.0082
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0052 0.0063
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0495 0.0717
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0565 0.3115 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0412 0.1181
Echinococcus granulosus dihydrofolate reductase 0.1 0.557 0.8109
Mycobacterium tuberculosis Conserved protein 0.0145 0.0746 0.1311
Schistosoma mansoni P2X receptor subunit 0.0269 0.1447 0.2106
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0924 0.5142 0.9228
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0088 0.0429 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0677 0.0986
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0052 0.0063
Mycobacterium tuberculosis Conserved protein 0.0145 0.0746 0.1311
Echinococcus multilocularis dna polymerase eta 0.0048 0.02 0.0198
Echinococcus granulosus dna polymerase kappa 0.0021 0.0046 0.0064
Echinococcus multilocularis p2X purinoceptor 4 0.0269 0.1447 0.1445
Schistosoma mansoni cpg binding protein 0.0091 0.0445 0.0648
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0347 0.6699
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0677 0.0986
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0018 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.0746 0.1311
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0347 0.0593
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0066 0.0116
Echinococcus granulosus GPCR family 2 0.0048 0.0199 0.0286
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0746 0.1257
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.0746 0.0744
Brugia malayi hypothetical protein 0.0077 0.0364 0.0649
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.0063
Brugia malayi CXXC zinc finger family protein 0.0086 0.0417 0.0746
Schistosoma mansoni hypothetical protein 0.0048 0.0199 0.0289
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.0063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0199 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0066 0.0097
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0018 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0076 0.0231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0779 0.1395
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0041 0.00000000030262
Echinococcus multilocularis dihydrofolate reductase 0.1 0.557 0.5569
Brugia malayi nuclear receptor NHR-88 0.0024 0.0066 0.0116
Entamoeba histolytica hypothetical protein 0.0077 0.0364 0.7076
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0737 0.0735
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0565 0.3115 0.9271
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0066 0.0116
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.02 0.0566
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0779 0.1395
Onchocerca volvulus 0.003 0.01 0.0396
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0051 0.0074
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0043 0.0073
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0066 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0041 0.00000000030262
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0002 0.0003
Schistosoma mansoni patched 1 0.0043 0.0172 0.0251
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0347 0.6699
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0066 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0066 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0066 0.0094
Toxoplasma gondii histone lysine methyltransferase SET1 0.0164 0.0853 0.2697
Echinococcus multilocularis p2X purinoceptor 4 0.0269 0.1447 0.1445
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.0746 0.1336
Onchocerca volvulus 0.003 0.01 0.0396
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0076 0.0662
Echinococcus granulosus microtubule associated protein 2 0.0737 0.4087 0.5949
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0066 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0066 0.0094
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0046 0.0068
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0076 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0066 0.0064
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0046 0.0086
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0052 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0364 0.0527
Mycobacterium ulcerans hypothetical protein 0.0145 0.0746 0.1311
Schistosoma mansoni hypothetical protein 0.1231 0.6868 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0139 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0746 0.1086
Echinococcus multilocularis lamin dm0 0.003 0.01 0.0098
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0052 0.0063
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0076 0.0175
Mycobacterium tuberculosis Conserved hypothetical protein 0.032 0.1736 0.3095
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0172 0.0306
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0074 0.0347 0.0619
Schistosoma mansoni apoptosis regulator bax 0.0088 0.0429 0.0625
Loa Loa (eye worm) glutaminase 2 0.0292 0.1577 0.2828
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0052 0.0073
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0052 0.0063
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0163 0.0457
Onchocerca volvulus 0.0086 0.0417 0.3013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0104 0.0518 0.1497
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0746 0.2179
Leishmania major DNA polymerase kappa, putative 0.0021 0.0046 0.0086
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0347 0.0985
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0018 0.0026
Brugia malayi follicle stimulating hormone receptor 0.0227 0.1209 0.2168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0041 0.00000000030262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0066 0.0116
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0241 0.0403
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0052 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0046 0.0086
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0033 0.0115 0.0314
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.0746 0.1083
Loa Loa (eye worm) hypothetical protein 0.0147 0.0761 0.1362
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0046 0.0068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0199 0.0353
Loa Loa (eye worm) hypothetical protein 0.003 0.0097 0.0171
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0052 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0473 0.0688
Echinococcus multilocularis microtubule associated protein 2 0.0737 0.4087 0.4086
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0021 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0066 0.0116
Loa Loa (eye worm) glutaminase 0.0292 0.1577 0.2828
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.043
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0495 0.0885
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0779 0.1395
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0116
Loa Loa (eye worm) hypothetical protein 0.0145 0.0746 0.1336
Echinococcus multilocularis musashi 0.003 0.01 0.0098
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0116
Brugia malayi dihydrofolate reductase family protein 0.1 0.557 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0051 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0608 0.3359 1
Entamoeba histolytica hypothetical protein 0.0077 0.0364 0.7076
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0052 0.0063
Onchocerca volvulus 0.0112 0.056 0.419
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0043 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0212 0.0581
Loa Loa (eye worm) hypothetical protein 0.0053 0.0227 0.0404
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.01 0.0177
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0035 0.0032
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0046 0.0064
Brugia malayi Inositol-1 0.0041 0.0163 0.029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0283 0.0478
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0241 0.0723
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0066 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0746 0.2351
Brugia malayi intermediate filament protein 0.003 0.01 0.0177
Brugia malayi CHE-14 protein 0.0043 0.0172 0.0306

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization at 10 uM after 24 hrs by fluorescence microscopy ChEMBL. 24928400
EC50 (binding) = 3000 nM Concentration required for half maximal activity was calculated in human nuclear oxysterol receptor liver X receptor-alpha in LiSA. ChEMBL. 11300870
EC50 (binding) = 3000 nM Concentration required for half maximal activity was calculated in human nuclear oxysterol receptor liver X receptor-alpha in LiSA. ChEMBL. 11300870
IC50 (binding) = 4.4 Displacement of biotinylated-ephrin-A1-Fc from EphA2-Fc receptor (unknown origin) preincubated for 1 hr followed by biotinylated-ephrin-A1-Fc addition measured after 4 hrs by ELISA ChEMBL. 26363867
Inhibition (binding) Inhibition of STAR in mouse MA-10 cells assessed as inhibition of dbcAMP-stimulated cholesterol synthesis at 10 uM after 2 hrs by RIA ChEMBL. 22575868
RE (binding) = 0.2 Tested for its ability to activate Liver X receptor-alpha expressed as Relative efficacy determined by maximal increase in relative fluorescence in LiSA ChEMBL. 11300870

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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