Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Saccharomyces cerevisiae | dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.77 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.77 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.77 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.77 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 9.5 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 9.5 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 9.5 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 9.5 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (functional) | = 10 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (functional) | = 10 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (binding) | = 246 uM | Inhibitory activity against rat liver dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 246 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 246 uM | Inhibitory activity against rat liver dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 246 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
Selectivity (binding) | = 25.9 | Ratio of inhibitory concentration of rat liver and Pneumocystis carinii DHFR. | ChEMBL. | 8627607 |
Selectivity (binding) | = 25.9 | Ratio of IC50 rat liver DHFR vs IC50 of P. carinii DHFR | ChEMBL. | 8632434 |
Selectivity (binding) | = 319 | Ratio of inhibitory concentration of rat liver and Toxoplasma gondii DHFR | ChEMBL. | 8627607 |
Selectivity (binding) | = 319 | Ratio of IC50 rat liver DHFR vs IC50 of T. gondii DHFR | ChEMBL. | 8632434 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 8632434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.