TDR Targets

Basic information

Technical information

TDR Targets ID: 29051
Name: 6-[(4-methoxyphenyl)sulfanylmethyl]pteridine- 2,4-diamine
MW: 314.366 | Formula: C14H14N6OS
H donors: 2 H acceptors: 4 LogP: 1.14 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)SCc1cnc2c(n1)c(N)nc(n2)N
InChi: 1S/C14H14N6OS/c1-21-9-2-4-10(5-3-9)22-7-8-6-17-13-11(18-8)12(15)19-14(16)20-13/h2-6H,7H2,1H3,(H4,15,16,17,19,20)
InChiKey: PTTIXOAZMYSSNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[[(4-methoxyphenyl)thio]methyl]pteridine-2,4-diamine
[2-amino-6-[[(4-methoxyphenyl)thio]methyl]pteridin-4-yl]amine
174654-76-3
2,4-Pteridinediamine, 6-[(4-methoxyphenylthio)methyl], 0.3 hydrate
AIDS-041310
2,4-Pteridinediamine, 6-((4-methoxyphenylthio)methyl), 0.3 hydrate
AIDS041310

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Starlite/ChEMBL	References
Rattus norvegicus	Dihydrofolate reductase	Starlite/ChEMBL	References
Pneumocystis carinii	Dihydrofolate reductase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Echinococcus granulosus	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Brugia malayi	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	hypothetical protein	Get druggable targets OG5_128410	All targets in OG5_128410
Chlamydia trachomatis	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	Dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Mycobacterium ulcerans	dihydrofolate reductase DfrA	Get druggable targets OG5_128410	All targets in OG5_128410
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	ko:K00560 thymidylate synthase [EC2.1.1.45], putative	Get druggable targets OG5_127385	All targets in OG5_127385
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative	Get druggable targets OG5_128410	All targets in OG5_128410
Brugia malayi	dihydrofolate reductase family protein	Get druggable targets OG5_128410	All targets in OG5_128410
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Schistosoma mansoni	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium yoelii	thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Onchocerca volvulus		Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	Get druggable targets OG5_128410	All targets in OG5_128410
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	Get druggable targets OG5_128410	All targets in OG5_128410
Leishmania major	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	36.0 %
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	209 aa	29.2 %
Plasmodium yoelii	thymidylate synthase, putative	Dihydrofolate reductase	187 aa	212 aa	27.8 %
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Dihydrofolate reductase	187 aa	182 aa	34.1 %
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	36.0 %
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	182 aa	33.5 %
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	210 aa	30.0 %
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	193 aa	32.1 %
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	202 aa	29.2 %
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Dihydrofolate reductase	187 aa	187 aa	35.8 %
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	34.3 %
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	211 aa	28.4 %
Leishmania major	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	36.0 %
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	209 aa	29.2 %
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	210 aa	30.0 %
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Dihydrofolate reductase	187 aa	191 aa	31.9 %
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	206 aa	193 aa	29.5 %
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	33.7 %
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	186 aa	37.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	chromatin regulatory protein sir2	0.0051	0.0851	0.0851
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0348	0.737	1
Brugia malayi	Pre-SET motif family protein	0.0029	0.0371	0.0371
Loa Loa (eye worm)	glutamate receptor	0.0045	0.0703	0.0703
Echinococcus multilocularis	histone deacetylase 6	0.0022	0.0197	0.0197
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0223	0.0223
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0492	0.0492
Schistosoma mansoni	chromatin regulatory protein sir2	0.0051	0.0851	0.0851
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0341	0.7219	0.9795
Loa Loa (eye worm)	histone deacetylase 1	0.0076	0.1384	0.1384
Loa Loa (eye worm)	PXA domain-containing protein	0.0023	0.0223	0.0223
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0051	0.0851	0.0932
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0076	0.1384	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0371	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3639	0.3639
Echinococcus multilocularis	smad	0.0016	0.008	0.008
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0223	0.0223
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.2883	0.2883
Brugia malayi	Cytochrome P450 family protein	0.0058	0.0996	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0492	0.0492
Schistosoma mansoni	chromatin regulatory protein sir2	0.0348	0.737	0.737
Plasmodium vivax	histone deacetylase 1, putative	0.0076	0.1384	0.1691
Mycobacterium tuberculosis	Hypothetical protein	0.0062	0.1078	0.1078
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0341	0.7219	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.104	0.104
Leishmania major	histone deacetylase, putative	0.0022	0.0197	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Onchocerca volvulus		0.0035	0.0492	0.0632
Brugia malayi	regulator of G-protein signaling egl-10	0.0032	0.0416	0.0416
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Echinococcus multilocularis	regulator of G protein signaling 7	0.0032	0.0416	0.0416
Echinococcus multilocularis	axis inhibition protein axin	0.0023	0.0223	0.0223
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.004	0.0611	0.0611
Trypanosoma cruzi	histone deacetylase, putative	0.0022	0.0197	0.0267
Trichomonas vaginalis	histone deacetylase, putative	0.0076	0.1384	0.1625
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.104	0.1441
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0023	0.0223	0.0223
Schistosoma mansoni	chromatin regulatory protein sir2	0.0348	0.737	0.737
Schistosoma mansoni	histone deacetylase 1 2 3	0.0022	0.0197	0.0197
Echinococcus granulosus	regulator of G protein signaling 7	0.0032	0.0416	0.0416
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0492	0.0492
Trypanosoma cruzi	histone deacetylase 1, putative	0.0076	0.1384	0.1879
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0371	0.0371
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0468	1	1
Brugia malayi	histone deacetylase 11	0.0022	0.0197	0.0197
Echinococcus granulosus	regulator of G protein signaling 7	0.0032	0.0416	0.0416
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0492	0.042
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.2883	0.2883
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0051	0.0851	0.0851
Echinococcus granulosus	expressed protein	0.0444	0.9466	0.9466
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0348	0.737	1
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0051	0.0851	0.0879
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0492	0.0492
Giardia lamblia	Hypothetical protein	0.0348	0.737	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0051	0.0851	0.0851
Brugia malayi	beta-lactamase family protein	0.0035	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0492	0.0492
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0468	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.2883	0.2883
Toxoplasma gondii	ABC1 family protein	0.0035	0.0492	0.0681
Trichomonas vaginalis	glucosylceramidase, putative	0.0212	0.4384	0.5822
Trypanosoma cruzi	histone deacetylase, putative	0.0022	0.0197	0.0267
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0348	0.737	1
Schistosoma mansoni	histone deacetylase 4 5	0.0022	0.0197	0.0197
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0037	0.0544	0.0544
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0023	0.0223	0.0223
Brugia malayi	Histone deacetylase 1	0.0076	0.1384	0.1384
Echinococcus granulosus	histone deacetylase 1	0.0076	0.1384	0.1384
Echinococcus granulosus	histone deacetylase 3	0.0076	0.1384	0.1384
Echinococcus granulosus	histone deacetylase	0.0022	0.0197	0.0197
Echinococcus multilocularis	regulator of G protein signaling	0.0023	0.0223	0.0223
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0051	0.0851	0.0851
Onchocerca volvulus		0.013	0.2572	0.5091
Loa Loa (eye worm)	histone deacetylase 7A	0.0022	0.0197	0.0197
Loa Loa (eye worm)	histone deacetylase	0.0022	0.0197	0.0197
Brugia malayi	A-kinase anchor protein 10, precursor	0.0023	0.0223	0.0223
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0341	0.7219	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.104	0.104
Trichomonas vaginalis	glucosylceramidase, putative	0.0307	0.6464	0.8732
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0492	0.0492
Loa Loa (eye worm)	histone deacetylase 3	0.0076	0.1384	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0492	0.0492
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0023	0.0223	0.0223
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0348	0.737	0.737
Echinococcus granulosus	histone deacetylase 6	0.0022	0.0197	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.1078	0.1196
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.104	0.104
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.104	0.104
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0023	0.0223	0.0223
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.013	0.2572	0.2572
Echinococcus granulosus	axis inhibition protein axin	0.0023	0.0223	0.0223
Brugia malayi	thymidylate synthase	0.013	0.2572	0.2572
Brugia malayi	N-terminal motif family protein	0.0178	0.3639	0.3639
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0223	0.0223
Plasmodium vivax	hypothetical protein, conserved	0.0051	0.0851	0.0932
Loa Loa (eye worm)	transcriptional regulator	0.0051	0.0851	0.0851
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0051	0.0851	0.0932
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0037	0.0544	0.0544
Schistosoma mansoni	Smad4	0.0016	0.008	0.008
Toxoplasma gondii	histone deacetylase SIR2	0.0051	0.0851	0.1179
Schistosoma mansoni	hypothetical protein	0.0167	0.3399	0.3399
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0051	0.0851	0.0932
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.104	0.104
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0051	0.0838	0.0838
Schistosoma mansoni	dihydrofolate reductase	0.0468	1	1
Brugia malayi	Histone deacetylase family protein	0.0022	0.0197	0.0197
Leishmania major	histone deacetylase, putative	0.0076	0.1384	0.1879
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0023	0.0223	0.0223
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0076	0.1384	0.1625
Schistosoma mansoni	hypothetical protein	0.0167	0.3399	0.3399
Trichomonas vaginalis	glucosylceramidase, putative	0.0307	0.6464	0.8732
Echinococcus granulosus	thymidylate synthase	0.013	0.2572	0.2572
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0347	0.0347
Chlamydia trachomatis	dihydrofolate reductase	0.0468	1	0.5
Onchocerca volvulus		0.0035	0.0492	0.0632
Trypanosoma cruzi	histone deacetylase 1, putative	0.0076	0.1384	0.1879
Echinococcus multilocularis	histone deacetylase 8	0.0022	0.0197	0.0197
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0492	0.0492
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0023	0.0223	0.0223
Trichomonas vaginalis	glucosylceramidase, putative	0.0212	0.4384	0.5822
Echinococcus granulosus	histone deacetylase 6	0.0022	0.0197	0.0197
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.008	0.008
Brugia malayi	metabotropic glutamate receptor type 2	0.0022	0.0201	0.0201
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0341	0.7219	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.104	0.104
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0371	0.0371
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0051	0.0851	0.0851
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.2883	0.2883
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0051	0.0851	0.0851
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0178	0.3639	0.738
Toxoplasma gondii	histone deacetylase HDAC4	0.0022	0.0197	0.0273
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0051	0.0851	0.0851
Loa Loa (eye worm)	RGS-3 protein	0.0023	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0851	0.0851
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0371	0.0371
Trichomonas vaginalis	histone deacetylase, putative	0.0076	0.1384	0.1625
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0023	0.0223	0.0223
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0492	0.0492
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0341	0.7219	0.9795
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0371	0.0371
Trichomonas vaginalis	glucosylceramidase, putative	0.0307	0.6464	0.8732
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0051	0.0851	0.1155
Plasmodium vivax	SET domain protein, putative	0.0029	0.0371	0.0247
Onchocerca volvulus		0.0035	0.0492	0.0632
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Echinococcus multilocularis	thymidylate synthase	0.013	0.2572	0.2572
Leishmania major	histone deacetylase, putative	0.0076	0.1384	0.1879
Trypanosoma cruzi	histone deacetylase, putative	0.0022	0.0197	0.0267
Loa Loa (eye worm)	dihydrofolate reductase	0.0468	1	1
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0348	0.737	1
Echinococcus granulosus	Regulator of G protein signaling 20	0.0023	0.0223	0.0223
Trichomonas vaginalis	glucosylceramidase, putative	0.0201	0.4146	0.5488
Trypanosoma brucei	SIR2-like protein 4, putative	0.0051	0.0851	0.1155
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.4634	0.4634
Brugia malayi	regulator of G-protein signaling rgs-7	0.0023	0.0223	0.0223
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0051	0.0851	0.1155
Echinococcus granulosus	histone deacetylase 8	0.0022	0.0197	0.0197
Brugia malayi	beta-lactamase	0.0035	0.0492	0.0492
Schistosoma mansoni	chromatin regulatory protein sir2	0.0051	0.0851	0.0851
Schistosoma mansoni	histone deacetylase	0.0076	0.1384	0.1384
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0348	0.737	0.737
Loa Loa (eye worm)	hypothetical protein	0.0055	0.093	0.093
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Schistosoma mansoni	z-protein (S1r protein)	0.0032	0.0416	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Plasmodium falciparum	histone deacetylase 1	0.0076	0.1384	0.1691
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0492	0.0492
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0051	0.0851	0.1155
Brugia malayi	MH1 domain containing protein	0.0016	0.008	0.008
Loa Loa (eye worm)	transcriptional regulator	0.0348	0.737	0.737
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0223	0.0223
Echinococcus granulosus	histone deacetylase 6	0.0022	0.0197	0.0197
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0051	0.0851	0.0851
Toxoplasma gondii	histone deacetylase HDAC2	0.0076	0.1384	0.1918
Loa Loa (eye worm)	transcription factor SMAD2	0.0239	0.4967	0.4967
Echinococcus granulosus	histone deacetylase 7	0.0022	0.0197	0.0197
Brugia malayi	hypothetical protein	0.0023	0.0223	0.0223
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0492	0.0492
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.4238	0.4238
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0492	0.0492
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.008	0.008
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0051	0.0851	0.0851
Mycobacterium ulcerans	thymidylate synthase	0.013	0.2572	0.2572
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0371	0.0371
Echinococcus multilocularis	histone deacetylase 6	0.0022	0.0197	0.0197
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0045	0.0703	0.0703
Echinococcus multilocularis	dihydrofolate reductase	0.0468	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0144	0.2883	0.2883
Trichomonas vaginalis	glucosylceramidase, putative	0.0201	0.4146	0.5488
Mycobacterium ulcerans	lipase LipD	0.0035	0.0492	0.0492
Leishmania major	hypothetical protein, conserved	0.0035	0.0492	0.0667
Trypanosoma brucei	histone deacetylase 1	0.0076	0.1384	0.1879
Echinococcus granulosus	axis inhibition protein axin	0.0023	0.0223	0.0223
Trypanosoma brucei	histone deacetylase, putative	0.0022	0.0197	0.0267
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0076	0.1384	0.1625
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.2883	0.2883
Echinococcus multilocularis	histone deacetylase	0.0022	0.0197	0.0197
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0023	0.0223	0.0223
Loa Loa (eye worm)	Smad1	0.0016	0.008	0.008
Trypanosoma brucei	histone deacetylase 2	0.0022	0.0197	0.0267
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0492	0.0667
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Trichomonas vaginalis	histone deacetylase, putative	0.0076	0.1384	0.1625
Trypanosoma cruzi	histone deacetylase, putative	0.0022	0.0197	0.0267
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0492	0.0492
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.008	0.008
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0492	0.0667
Trichomonas vaginalis	glucosylceramidase, putative	0.0201	0.4146	0.5488
Echinococcus multilocularis	regulator of G protein signaling 7	0.0032	0.0416	0.0416
Loa Loa (eye worm)	cytochrome P450 family protein	0.0058	0.0996	0.0996
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0055	0.093	0.093
Schistosoma mansoni	metabotropic glutamate receptor	0.0022	0.0201	0.0201
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0492	0.0492
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0051	0.0851	0.0879
Trichomonas vaginalis	glucosylceramidase, putative	0.0307	0.6464	0.8732
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0051	0.0851	0.0851
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0023	0.0223	0.0223
Schistosoma mansoni	histone deacetylase hda2	0.0022	0.0197	0.0197
Toxoplasma gondii	histone deacetylase HDAC5	0.0022	0.0197	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1384	0.1384
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0492	0.0492
Onchocerca volvulus		0.0234	0.4862	1
Toxoplasma gondii	histone deacetylase HDAC3	0.0076	0.1384	0.1918
Echinococcus granulosus	Smad4	0.0016	0.008	0.008
Schistosoma mansoni	smad	0.0016	0.008	0.008
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0492	0.0492
Trichomonas vaginalis	glucosylceramidase, putative	0.0307	0.6464	0.8732
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.104	0.1411
Echinococcus multilocularis	histone deacetylase 6	0.0022	0.0197	0.0197
Brugia malayi	Histone deacetylase family protein	0.0022	0.0197	0.0197
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0492	0.0375
Trichomonas vaginalis	histone deacetylase, putative	0.0076	0.1384	0.1625
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.008	0.008
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0492	0.0667
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0348	0.737	0.737
Onchocerca volvulus		0.0029	0.0371	0.0372
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.013	0.2572	0.2572
Brugia malayi	Smad1	0.0016	0.008	0.008
Trichomonas vaginalis	glucosylceramidase, putative	0.0201	0.4146	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0492	0.0492
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Brugia malayi	MH1 domain containing protein	0.0016	0.008	0.008
Echinococcus granulosus	regulator of G protein signaling 3	0.0023	0.0223	0.0223
Schistosoma mansoni	chromatin regulatory protein sir2	0.0051	0.0851	0.0851
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0023	0.0223	0.0223
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0223	0.0223
Trypanosoma brucei	histone deacetylase 4	0.0022	0.0197	0.0267
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0371	0.0371
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0341	0.7219	0.9795
Echinococcus multilocularis	Smad4	0.0016	0.008	0.008
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0492	0.0492
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0492	0.0375
Loa Loa (eye worm)	glutamate receptor	0.0018	0.0109	0.0109
Brugia malayi	PXA domain containing protein	0.0023	0.0223	0.0223
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0492	0.0492
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0492	0.0375
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0348	0.737	0.737
Trichomonas vaginalis	glucosylceramidase, putative	0.0307	0.6464	0.8732
Leishmania major	sir2-family protein-like protein	0.0051	0.0851	0.1155
Schistosoma mansoni	chromatin regulatory protein sir2	0.0348	0.737	0.737
Brugia malayi	Dihydrofolate reductase	0.0468	1	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0492	0.0492
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0051	0.0851	0.0851
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.104	0.104
Brugia malayi	hypothetical protein	0.0023	0.0223	0.0223
Onchocerca volvulus	Glucosylceramidase homolog	0.0201	0.4146	0.8465
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0223	0.0223
Brugia malayi	PXA domain containing protein	0.0023	0.0223	0.0223
Toxoplasma gondii	histone deacetylase SIR2-like	0.0051	0.0851	0.1179
Echinococcus granulosus	chromatin regulatory protein sir2	0.0348	0.737	0.737
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0307	0.6464	0.6464
Echinococcus multilocularis	regulator of G protein signaling 3	0.0023	0.0223	0.0223
Schistosoma mansoni	regulator of G protein signaling	0.0032	0.0416	0.0416
Loa Loa (eye worm)	transcriptional regulator	0.0051	0.0851	0.0851
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0144	0.2883	0.2883
Trichomonas vaginalis	glucosylceramidase, putative	0.0201	0.4146	0.5488
Brugia malayi	MH2 domain containing protein	0.0016	0.008	0.008
Trichomonas vaginalis	histone deacetylase, putative	0.0076	0.1384	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0416	0.0416
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0492	0.0375
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.2883	0.2883
Echinococcus multilocularis	histone deacetylase 3	0.0076	0.1384	0.1384
Schistosoma mansoni	smad1 5 8 and	0.0016	0.008	0.008
Echinococcus granulosus	smad	0.0016	0.008	0.008
Brugia malayi	MH2 domain containing protein	0.0239	0.4967	0.4967
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0492	0.0492
Echinococcus multilocularis	geminin	0.0167	0.3399	0.3399
Loa Loa (eye worm)	MH2 domain-containing protein	0.0239	0.4967	0.4967
Echinococcus multilocularis	expressed protein	0.0444	0.9466	0.9466
Echinococcus multilocularis	regulator of G protein signaling 3	0.0023	0.0223	0.0223
Echinococcus granulosus	regulator of G protein signaling 3	0.0023	0.0223	0.0223
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0492	0.0492
Schistosoma mansoni	histone deacetylase hda2	0.0022	0.0197	0.0197
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0468	1	1
Leishmania major	histone deacetylase, putative	0.0022	0.0197	0.0267
Echinococcus multilocularis	histone deacetylase 1	0.0076	0.1384	0.1384
Trypanosoma cruzi	histone deacetylase, putative	0.0022	0.0197	0.0267
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0051	0.0851	0.0851
Trichomonas vaginalis	esterase, putative	0.0035	0.0492	0.0375
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0023	0.0223	0.0223
Loa Loa (eye worm)	sirtuin 4	0.0051	0.0851	0.0851
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0051	0.0851	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0197	0.0197
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0023	0.0223	0.0223
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0492	0.0492
Entamoeba histolytica	histone deacetylase, putative	0.0076	0.1384	0.1625
Schistosoma mansoni	histone deacetylase 4 5	0.0022	0.0197	0.0197
Brugia malayi	hypothetical protein	0.0062	0.1078	0.1078
Giardia lamblia	Histone deacetylase	0.0076	0.1384	0.0818
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0492	0.0492
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0023	0.0223	0.0223
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.008	0.008
Schistosoma mansoni	histone deacetylase	0.0076	0.1384	0.1384
Brugia malayi	histone deacetylase 1 (HD1)	0.0076	0.1384	0.1384
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0371	0.0513
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.104	0.104
Loa Loa (eye worm)	thymidylate synthase	0.013	0.2572	0.2572
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Brugia malayi	Pre-SET motif family protein	0.0206	0.4238	0.4238
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0051	0.0851	0.1155
Trichomonas vaginalis	glucosylceramidase, putative	0.0201	0.4146	0.5488
Schistosoma mansoni	smad1 5 8 and	0.0016	0.008	0.008
Schistosoma mansoni	smad1 5 8 and	0.0016	0.008	0.008
Brugia malayi	beta-lactamase family protein	0.0035	0.0492	0.0492
Trichomonas vaginalis	histone deacetylase, putative	0.0076	0.1384	0.1625
Echinococcus granulosus	dihydrofolate reductase	0.0468	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0201	0.4146	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0492	0.0492
Echinococcus granulosus	geminin	0.0167	0.3399	0.3399
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.4862	0.649
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0492	0.0492
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0051	0.0851	0.0879
Schistosoma mansoni	metabotropic glutamate receptor	0.0037	0.0544	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.013	0.2572	0.2572
Brugia malayi	MH2 domain containing protein	0.0016	0.008	0.008
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0032	0.0416	0.0416
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0348	0.737	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.008	0.008
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0492	0.0375
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.008	0.008
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0348	0.737	1
Loa Loa (eye worm)	histone deacetylase 11	0.0022	0.0197	0.0197
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0492	0.0492
Echinococcus multilocularis	histone deacetylase 7	0.0022	0.0197	0.0197
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0492	0.0492
Toxoplasma gondii	histone deacetylase HDAC1	0.0022	0.0197	0.0273
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0371	0.0371
Entamoeba histolytica	hypothetical protein, conserved	0.0051	0.0851	0.0879
Schistosoma mansoni	axis inhibition protein axin	0.0023	0.0223	0.0223
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0055	0.093	0.093
Leishmania major	silent information regulator 2, putative	0.0348	0.737	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0492	0.0492
Schistosoma mansoni	axis inhibition protein axin	0.0023	0.0223	0.0223
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0062	0.1078	0.1463
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0348	0.737	1
Brugia malayi	histone deacetylase 3 (HD3)	0.0076	0.1384	0.1384
Echinococcus multilocularis	axis inhibition protein axin	0.0023	0.0223	0.0223
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0223	0.0223
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0307	0.6464	0.6464
Trypanosoma brucei	histone deacetylase 3	0.0022	0.0197	0.0267
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.2883	0.2883

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3 uM	Inhibition of Toxoplasma gondii cell growth	ChEMBL.	8632434
IC50 (functional)	= 3 uM	Inhibition of Toxoplasma gondii cell growth	ChEMBL.	8632434
IC50 (binding)	= 10.2 uM	Inhibitory activity of the compound against rat liver dihydrofolate reductase	ChEMBL.	8632434
IC50 (binding)	= 10.2 uM	Inhibitory activity of the compound against rat liver dihydrofolate reductase	ChEMBL.	8632434
IC50 (binding)	= 14 uM	Inhibitory activity against Toxoplasma gondii dihydrofolate reductase	ChEMBL.	8632434
IC50 (binding)	= 14 uM	Inhibitory activity against Toxoplasma gondii dihydrofolate reductase	ChEMBL.	8632434
IC50 (binding)	= 17.2 uM	Inhibitory activity against Pneumocystis carinii dihydrofolate reductase	ChEMBL.	8632434
IC50 (binding)	= 17.2 uM	Inhibitory activity against Pneumocystis carinii dihydrofolate reductase	ChEMBL.	8632434
Selectivity (binding)	= 0.59	Ratio of IC50 rat liver DHFR vs IC50 of P. carinii DHFR	ChEMBL.	8632434
Selectivity (binding)	= 0.73	Ratio of IC50 rat liver DHFR vs IC50 of T. gondii DHFR	ChEMBL.	8632434

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Toxoplasma gondii	ChEMBL23	8632434

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL23146
PubChem: 464019

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 29051