Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Nitric oxide synthase, inducible | 0.0295 | 0.8717 | 1 |
Leishmania major | p450 reductase, putative | 0.0333 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0205 | 0.5684 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0127 | 0.3033 | 0.3033 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0333 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0333 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0165 | 0.4316 | 0.4316 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0127 | 0.3033 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0127 | 0.3033 | 0.5 |
Echinococcus granulosus | methionine synthase reductase | 0.0205 | 0.5684 | 0.5684 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0295 | 0.8717 | 0.8159 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0333 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0127 | 0.3033 | 0.3033 |
Plasmodium vivax | hypothetical protein, conserved | 0.0127 | 0.3033 | 0.3033 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0333 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0295 | 0.8717 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0205 | 0.5684 | 0.5684 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0168 | 0.4402 | 0.4402 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0333 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0127 | 0.3033 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0295 | 0.8717 | 0.8717 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0127 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0333 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0205 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0038 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0127 | 0.3033 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.3033 | 0.3033 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0333 | 1 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0333 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0333 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0333 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0127 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0333 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0127 | 0.3033 | 0.5 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0127 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0127 | 0.3033 | 0.3033 |
Treponema pallidum | flavodoxin | 0.0127 | 0.3033 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0333 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0333 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0205 | 0.5684 | 0.5684 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0333 | 1 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0127 | 0.3033 | 0.3033 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0127 | 0.3033 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0165 | 0.4316 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0205 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0038 | 0 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0295 | 0.8717 | 0.8717 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0333 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0165 | 0.4316 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0333 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0333 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0333 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0333 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Trypanosoma cruzi | p450 reductase, putative | 0.0333 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14.1 uM | Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain | ChEMBL. | 1849994 |
Ki (binding) | = 14.1 uM | Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain | ChEMBL. | 1849994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.