Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0609 | 0.3492 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1596 | 1 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.1596 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1596 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1596 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0609 | 0.3492 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.013 | 0.0335 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0087 | 0.0047 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0609 | 0.3492 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1596 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.1596 | 1 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.013 | 0.0335 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0609 | 0.3492 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0609 | 0.3492 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0087 | 0.0047 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.008 | 0 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0085 | 0.0037 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0609 | 0.3492 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.1596 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.1596 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0609 | 0.3492 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
% (functional) | = 3.19 | Percent packed cell volume at 10 mg/kg per day | ChEMBL. | 7277393 |
Days (functional) | = 11.6 | Effect on P-388 lymphocytic leukemia growth at a given dose 10 mg/kg per day ip expressed as average survival days of treated mice | ChEMBL. | 7277393 |
Inhibition (functional) | = 99.2 % | Percent inhibition of ehrlich ascites carcinoma growth at 10 mg/kg per day | ChEMBL. | 7277393 |
Inhibition (functional) | = 99.2 % | Percent inhibition of ehrlich ascites carcinoma growth at 10 mg/kg per day | ChEMBL. | 7277393 |
Survivors at day 9 (functional) | = 6 | Effect on ehrlich ascites carcinoma growth in CF1 mice at 10 mg/kg per day ip survival at day 9; 6/6 | ChEMBL. | 7277393 |
T/C (functional) | = 122 | Effect on P-388 lymphocytic leukemia growth at a given dose 10 mg/kg per day ip expressed as ratio of treated / control (T/C>125 is required for significant activity) | ChEMBL. | 7277393 |
Volume (functional) | = 0.28 | Percent packed cell volume at 10 mg/kg per day per mouse | ChEMBL. | 7277393 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.