Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0382 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0382 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0382 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0382 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0236 | 0.5375 | 0.5375 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0382 | 1 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0382 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0382 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0382 | 1 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0382 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0382 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0382 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0382 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0382 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0382 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0382 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0236 | 0.5375 | 0.5375 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0236 | 0.5375 | 0.5375 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0382 | 1 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0382 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0382 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0236 | 0.5375 | 0.5375 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 29 % | Percent inhibition of proteinuria by compound dose of 100 mg/kg given perorally to murine in chronic graft-versus-host-disease test | ChEMBL. | 11738579 |
Inhibition (functional) | = 29 % | Percent inhibition of proteinuria by compound dose of 100 mg/kg given perorally to murine in chronic graft-versus-host-disease test | ChEMBL. | 11738579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.