TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 838.944 | Formula: C45H54N6O10
H donors: 7 H acceptors: 9 LogP: 4.39 Rotable bonds: 27
Rule of 5 violations (Lipinski): 3
SMILES: O=C(/C=C\c1ccc(cc1)O)NCCCC[C@H](C(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N([C@H](C(=O)N)Cc1ccccc1)C)CC(=O)O
InChi: 1S/C45H54N6O10/c1-45(2,3)61-44(60)50-35(25-30-27-48-34-16-9-8-14-32(30)34)40(56)33(15-10-11-23-47-38(53)22-19-28-17-20-31(52)21-18-28)42(58)49-36(26-39(54)55)43(59)51(4)37(41(46)57)24-29-12-6-5-7-13-29/h5-9,12-14,16-22,27,33,35-37,48,52H,10-11,15,23-26H2,1-4H3,(H2,46,57)(H,47,53)(H,49,58)(H,50,60)(H,54,55)/b22-19-/t33-,35+,36+,37+/m1/s1
InChiKey: NYIVVJVUFWFIAR-FFHGGSCYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholecystokinin B receptor	Starlite/ChEMBL	No references
Cavia porcellus	Cholecystokinin A receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	sulfakinin receptor protein	Get druggable targets OG5_132882	All targets in OG5_132882
Brugia malayi	hypothetical protein	Get druggable targets OG5_132882	All targets in OG5_132882
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132882	All targets in OG5_132882

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	dro:myosuppressin receptor	Cholecystokinin A receptor	430 aa	369 aa	23.0 %
Echinococcus multilocularis	dro:myosuppressin receptor	Cholecystokinin A receptor	430 aa	369 aa	23.0 %
Onchocerca volvulus		Cholecystokinin A receptor	430 aa	377 aa	22.3 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Cholecystokinin A receptor	430 aa	356 aa	27.5 %
Echinococcus multilocularis	g protein coupled receptor	Cholecystokinin A receptor	430 aa	405 aa	24.2 %
Echinococcus granulosus	g protein coupled receptor	Cholecystokinin A receptor	430 aa	415 aa	23.1 %
Echinococcus granulosus	biogenic amine 5HT receptor	Cholecystokinin A receptor	430 aa	428 aa	23.6 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Cholecystokinin A receptor	430 aa	382 aa	25.1 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Cholecystokinin A receptor	430 aa	375 aa	26.4 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Cholecystokinin A receptor	430 aa	384 aa	21.4 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Cholecystokinin A receptor	430 aa	373 aa	28.4 %
Onchocerca volvulus		Cholecystokinin A receptor	430 aa	410 aa	25.4 %
Echinococcus multilocularis	g protein coupled receptor	Cholecystokinin A receptor	430 aa	414 aa	23.4 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Cholecystokinin A receptor	430 aa	383 aa	22.7 %
Echinococcus multilocularis	serotonin receptor	Cholecystokinin A receptor	430 aa	427 aa	23.7 %
Echinococcus multilocularis	neuropeptides capa receptor	Cholecystokinin A receptor	430 aa	414 aa	19.8 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Cholecystokinin A receptor	430 aa	378 aa	23.8 %
Onchocerca volvulus		Cholecystokinin A receptor	430 aa	397 aa	29.0 %
Schistosoma japonicum	FMRFamide receptor, putative	Cholecystokinin A receptor	430 aa	364 aa	22.8 %
Onchocerca volvulus	Phospholipase d-related homolog	Cholecystokinin A receptor	430 aa	359 aa	20.9 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Cholecystokinin A receptor	430 aa	373 aa	27.3 %
Onchocerca volvulus	Forkhead box protein biniou homolog	Cholecystokinin A receptor	430 aa	353 aa	22.1 %
Echinococcus multilocularis	orexin receptor type 2	Cholecystokinin A receptor	430 aa	381 aa	23.6 %
Echinococcus granulosus	g protein coupled receptor	Cholecystokinin A receptor	430 aa	398 aa	23.9 %
Echinococcus granulosus	orexin receptor type 2	Cholecystokinin A receptor	430 aa	383 aa	23.2 %
Echinococcus granulosus	rhodopsin orphan GPCR	Cholecystokinin A receptor	430 aa	363 aa	19.6 %
Schistosoma mansoni	amine GPCR	Cholecystokinin A receptor	430 aa	409 aa	24.7 %
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	Cholecystokinin A receptor	430 aa	381 aa	21.5 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Cholecystokinin A receptor	430 aa	363 aa	24.5 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Cholecystokinin A receptor	430 aa	402 aa	26.1 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Cholecystokinin A receptor	430 aa	395 aa	24.8 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Cholecystokinin A receptor	430 aa	363 aa	19.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0	0.5
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0076	0.0181	0.1684
Giardia lamblia	NADPH oxidoreductase, putative	0.0841	0.2682	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0171	0.0619
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0841	0.2682	0.2682
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trypanosoma brucei	hypothetical protein, conserved	0.025	0.075	0.2718
Echinococcus granulosus	dna polymerase eta	0.0048	0.009	0.1307
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0024	0.0346
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0093	0.1356
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0076	0.0181	0.23
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Brugia malayi	RNase H family protein	0.0231	0.0686	0.8726
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0024	0.0088
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.012	0.1525
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0024	0.0086
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0116	0.0312	0.3967
Trypanosoma cruzi	ribonuclease H1, putative	0.0231	0.0686	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0171	0.0619
Entamoeba histolytica	hypothetical protein	0.0349	0.1074	1
Trypanosoma brucei	unspecified product	0.025	0.075	0.2718
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0024	0.0302
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.3079	1	1
Schistosoma mansoni	phosphoglucomutase	0.0231	0.0686	0.2486
Trypanosoma brucei	ribonuclease H1	0.0231	0.0686	0.2486
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0171	0.0619
Echinococcus granulosus	ribonuclease H1	0.0231	0.0686	1
Echinococcus multilocularis	dna polymerase eta	0.0048	0.009	0.1307
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0024	0.0346
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0076	0.0181	0.23
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0349	0.1074	0.1074
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0841	0.2682	0.2682
Brugia malayi	RNA binding protein	0.0073	0.0171	0.2172
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0171	0.0619
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0093	0.0337
Echinococcus multilocularis	ribonuclease H1	0.0231	0.0686	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0024	0.0024
Echinococcus multilocularis	transcription factor eb	0.0116	0.0312	0.4546
Schistosoma mansoni	hypothetical protein	0.0039	0.006	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.0171	0.2489
Trypanosoma brucei	RNA helicase, putative	0.0865	0.2759	1
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Giardia lamblia	Ribonuclease H	0.0231	0.0686	0.2558
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Schistosoma mansoni	phosphoglucomutase	0.0231	0.0686	0.2486
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.009	0.114
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Leishmania major	ribonuclease H1, putative	0.0231	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.031	0.3944
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0242	0.308
Schistosoma mansoni	hypothetical protein	0.0865	0.2759	1
Brugia malayi	RNase H family protein	0.0231	0.0686	0.8726
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.0181	0.0655
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0024	0.0346
Loa Loa (eye worm)	RNA binding protein	0.0073	0.0171	0.2172
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0024	0.5
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0024	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.006	0.0769
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Brugia malayi	RNase H family protein	0.0231	0.0686	0.8726
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.0352	0.448
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0	0.5
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0076	0.0181	0.2635
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.0171	0.2172
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0093	0.0337
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.0076	0.1109
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0076	0.0181	0.0655
Schistosoma mansoni	eyes absent homolog	0.0095	0.0242	0.0878
Brugia malayi	hypothetical protein	0.0261	0.0786	1
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0024	0.0221
Brugia malayi	MH2 domain containing protein	0.0128	0.0352	0.448
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0043	0.0624
Leishmania major	DNA polymerase eta, putative	0.0048	0.009	0.1307
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0171	0.0619
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0076	0.0181	0.2635
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Loa Loa (eye worm)	hypothetical protein	0.0057	0.012	0.1525
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0242	0.308
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.0171	0.2172
Echinococcus granulosus	tar DNA binding protein	0.0073	0.0171	0.2489
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0043	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.0352	0.448
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.0171	0.2172
Brugia malayi	hypothetical protein	0.0095	0.0242	0.308
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.0181	0.2635
Schistosoma mansoni	phosphoglucomutase	0.0231	0.0686	0.2486
Trichomonas vaginalis	conserved hypothetical protein	0.0492	0.1541	0.1541
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0116	0.031	0.3944
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0093	0.1184
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.006	0.0769
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0349	0.1074	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.0181	0.2635
Trypanosoma brucei	DNA polymerase eta, putative	0.0048	0.009	0.0325
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Giardia lamblia	NADPH oxidoreductase, putative	0.0841	0.2682	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0093	0.1356
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.0076	0.1109
Trypanosoma brucei	ingi protein (ORF1)	0.025	0.075	0.2718
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0231	0.0686	0.5
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.009	0.1307
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0093	0.1356
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0015	0.0054
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0349	0.1074	1
Treponema pallidum	ribonuclease H (rnhA)	0.0231	0.0686	0.5
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.025	0.075	0.2718
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0024	0.0346
Brugia malayi	TAR-binding protein	0.0073	0.0171	0.2172
Loa Loa (eye worm)	hypothetical protein	0.0261	0.0786	1
Trichomonas vaginalis	ribonuclease H1, putative	0.0231	0.0686	0.0686
Giardia lamblia	NADPH oxidoreductase, putative	0.0841	0.2682	1
Trypanosoma brucei	ingi protein (ORF1)	0.025	0.075	0.2718
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0093	0.1356
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.012	0.1525
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Brugia malayi	sulfakinin receptor protein	0.0261	0.0786	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Leishmania major	DNA polymerase eta, putative	0.0034	0.0043	0.0624
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Schistosoma mansoni	DNA polymerase eta	0.0048	0.009	0.0325
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0841	0.2682	0.2682
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0076	0.0181	0.2635
Trypanosoma cruzi	ribonuclease H1, putative	0.0231	0.0686	1
Echinococcus granulosus	transcription factor eb	0.0116	0.0312	0.4546
Loa Loa (eye worm)	hypothetical protein	0.0048	0.009	0.114
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Toxoplasma gondii	ribonuclease HI protein	0.0231	0.0686	1
Onchocerca volvulus	Ribonuclease H1 homolog	0.0231	0.0686	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0349	0.1074	0.1074
Trichomonas vaginalis	conserved hypothetical protein	0.0841	0.2682	0.2682
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0093	0.0337
Trichomonas vaginalis	modulator of drug activity B, putative	0.0349	0.1074	0.1074
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.012	0.1525
Brugia malayi	Flap endonuclease-1	0.0028	0.0024	0.0302
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0093	0.1184

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.2 nM	Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig pancreas Cholecystokinin type A receptor	ChEMBL.	No reference
IC50 (binding)	= 4.2 nM	Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig pancreas Cholecystokinin type A receptor	ChEMBL.	No reference
IC50 (binding)	= 710 nM	Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor	ChEMBL.	No reference
IC50 (binding)	= 710 nM	Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor	ChEMBL.	No reference
Max response (functional)	= 76 %	Compound was evaluated for its ability to stimulate PI hydrolysis in guinea pig pancreas relative to maximal response elicited by CCK-8	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL169126

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 290898