Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cholecystokinin A receptor | Starlite/ChEMBL | No references |
Homo sapiens | cholecystokinin B receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | sulfakinin receptor protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 0.9524 | 0.977 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0034 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0261 | 0.3202 | 0.3285 |
Brugia malayi | nuclear hormone receptor | 0.0726 | 0.9749 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.3202 | 0.3285 |
Brugia malayi | sulfakinin receptor protein | 0.0261 | 0.3202 | 0.3285 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0726 | 0.9749 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 uM | Ability to inhibit the binding of [125I]-CCK-8 to Cholecystokinin type A receptor in rat pancreas. | ChEMBL. | No reference |
IC50 (binding) | = 2.1 uM | Ability to inhibit the binding of [125I]-CCK-8 to Cholecystokinin type A receptor in rat pancreas. | ChEMBL. | No reference |
IC50 (binding) | = 3.1 uM | Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig. | ChEMBL. | No reference |
IC50 (binding) | = 3.1 uM | Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig. | ChEMBL. | No reference |
IC50 (binding) | = 8.6 uM | Ability to inhibit the binding of [125I]-CCK-8 to Cholecystokinin type B receptor in guinea pig cortex. | ChEMBL. | No reference |
IC50 (binding) | = 8.6 uM | Ability to inhibit the binding of [125I]-CCK-8 to Cholecystokinin type B receptor in guinea pig cortex. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.