Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0689 | 0.9419 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2212 | 0.2348 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0602 | 0.8144 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0642 | 0.8725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0654 | 0.8901 | 0.9449 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | steroid hormone receptor | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0075 | 0.038 | 0.0404 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.172 | 0.1606 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0075 | 0.038 | 0.0404 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.172 | 0.1726 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.038 | 0.0404 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0642 | 0.8725 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | ecdysteroid receptor | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0199 | 0.2212 | 0.2348 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0689 | 0.9419 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0075 | 0.038 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.038 | 0.0404 |
Brugia malayi | nuclear hormone receptor | 0.0075 | 0.038 | 0.0404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2 | compound was evaluated for its ability to produce catalepsy activity in rats; Dose administered perorally is 25 mg/kg | ChEMBL. | 6105217 |
Activity (functional) | = 3 | Compound was evaluated for its ability to block conditioned avoidance response (CAR) in rats; Dose administered perorally is 25 mg/kg; 51-75% block | ChEMBL. | 6105217 |
EDmin (functional) | = 25 mg kg-1 | Hypothermia in mice after perorla administration | ChEMBL. | 6105217 |
EDmin (functional) | = 25 mg kg-1 | Hypothermia in mice after perorla administration | ChEMBL. | 6105217 |
LD50 (ADMET) | = 100 mg kg-1 | Lethal dose in mice after perorla administration | ChEMBL. | 6105217 |
LD50 (ADMET) | = 100 mg kg-1 | Lethal dose in mice after perorla administration | ChEMBL. | 6105217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.