Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cholecystokinin A receptor | Starlite/ChEMBL | No references |
Homo sapiens | cholecystokinin B receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | sulfakinin receptor protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.1089 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1089 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1089 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1089 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0416 | 0.3591 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1089 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1089 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1089 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0147 | 0.0147 |
Brugia malayi | sulfakinin receptor protein | 0.0276 | 0.2255 | 0.2255 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.2255 | 0.2255 |
Schistosoma mansoni | eyes absent homolog | 0.0055 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1089 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0276 | 0.2255 | 0.2255 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0147 | 0.0147 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1089 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0634 | 0.5668 | 0.5668 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0147 | 0.0147 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0416 | 0.3591 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0416 | 0.3591 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0416 | 0.3591 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0416 | 0.3591 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0416 | 0.3591 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.8 nM | Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig pancreas Cholecystokinin type A receptor | ChEMBL. | No reference |
IC50 (binding) | = 3.8 nM | Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig pancreas Cholecystokinin type A receptor | ChEMBL. | No reference |
IC50 (binding) | = 1400 nM | Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor | ChEMBL. | No reference |
IC50 (binding) | = 1400 nM | Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor | ChEMBL. | No reference |
Max response (functional) | = 100 % | Compound was evaluated for its ability to stimulate PI hydrolysis in guinea pig pancreas relative to maximal response elicited by CCK-8 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.