Detailed information for compound 291032

Basic information

Technical information
  • TDR Targets ID: 291032
  • Name: 4-[2-(2,4-diphenyl-6-propan-2-ylpyridin-1-ium -1-yl)ethyl]benzenesulfonamide perchlorate
  • MW: 557.058 | Formula: C28H29ClN2O6S
  • H donors: 1 H acceptors: 6 LogP: 8.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-][Cl](=O)(=O)=O.CC(c1cc(cc([n+]1CCc1ccc(cc1)S(=O)(=O)N)c1ccccc1)c1ccccc1)C
  • InChi: 1S/C28H29N2O2S.ClHO4/c1-21(2)27-19-25(23-9-5-3-6-10-23)20-28(24-11-7-4-8-12-24)30(27)18-17-22-13-15-26(16-14-22)33(29,31)32;2-1(3,4)5/h3-16,19-21H,17-18H2,1-2H3,(H2,29,31,32);(H,2,3,4,5)/q+1;/p-1
  • InChiKey: VSUZTDANHMAYNC-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(2-isopropyl-4,6-diphenyl-pyridin-1-ium-1-yl)ethyl]benzenesulfonamide perchlorate
  • 4-[2-(2-isopropyl-4,6-diphenyl-1-pyridin-1-iumyl)ethyl]benzenesulfonamide perchlorate
  • 4-[2-(2,4-diphenyl-6-propan-2-yl-pyridin-1-ium-1-yl)ethyl]benzenesulfonamide perchlorate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Bos taurus Carbonic anhydrase IV Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis carbonic anhydrase Carbonic anhydrase IV   312 aa 259 aa 30.1 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 253 aa 26.9 %
Echinococcus granulosus carbonic anhydrase Carbonic anhydrase IV   312 aa 304 aa 29.6 %
Onchocerca volvulus Carbonic anhydrase IV   312 aa 252 aa 23.4 %
Leishmania infantum carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 26.7 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 264 aa 24.2 %
Brugia malayi Carbonic anhydrase like protein 2 precursor Carbonic anhydrase IV   312 aa 268 aa 24.6 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative Carbonic anhydrase IV   312 aa 264 aa 25.4 %
Loa Loa (eye worm) hypothetical protein Carbonic anhydrase IV   312 aa 268 aa 25.4 %
Leishmania mexicana carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 287 aa 26.8 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 265 aa 26.0 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Leishmania braziliensis carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 25.6 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 322 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0015 0.0027
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0008 0.0013 0.0003
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.0012 0.0022
Brugia malayi hypothetical protein 0.0092 0.0297 0.0297
Mycobacterium tuberculosis Probable oxidoreductase 0.0067 0.0212 0.2599
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0015 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0131 0.0224
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0325 0.0572
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0015 0.0015
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0001 0.000000000019982
Echinococcus multilocularis serotonin receptor 0.0008 0.0012 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0131 0.0127
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 0.5671
Toxoplasma gondii propionate-CoA ligase 0.0007 0.001 0.0006
Leishmania major GTP-binding protein, putative 0.0021 0.0057 0.0053
Brugia malayi hypothetical protein 0.0017 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Brugia malayi Thioredoxin reductase 0.0027 0.0075 0.0075
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0078
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0069 0.0065
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0027 0.0075 0.0863
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0015 0.0027
Chlamydia trachomatis metal transport ATPase 0.0009 0.0015 0.0544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0012 0.0022
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0013 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0017 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0069 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0083 0.0079
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0015 0.0027
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0015 0.0027
Brugia malayi neuropeptide F receptor 0.0008 0.0012 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0202 0.0356
Treponema pallidum hypothetical protein 0.0009 0.0015 0.8189
Echinococcus granulosus orexin receptor type 2 0.0008 0.0012 0.0022
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0015 0.0027
Brugia malayi Dopamine receptor 0.0008 0.0012 0.0012
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0122 0.0215
Leishmania major DNA polymerase kappa, putative 0.0013 0.0028 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0113 0.0103
Trypanosoma brucei unspecified product 0.0028 0.008 0.0076
Trichomonas vaginalis thymidine kinase, putative 0.0244 0.0807 0.0807
Onchocerca volvulus 0.0008 0.0012 0.0022
Echinococcus granulosus carbonic anhydrase 0.0101 0.0325 0.0572
Echinococcus multilocularis zinc finger protein 0.0005 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0009 0.0015 0.0003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0007 0.001 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0017 0.0029
Echinococcus multilocularis orexin receptor type 2 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0069 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Echinococcus granulosus bloom syndrome protein 0.0014 0.0034 0.0059
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0015 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.0012 0.0022
Leishmania major DNA polymerase eta, putative 0.0013 0.0028 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0017 0.0017
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0009 0.0015 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0015 0.0027
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.001 0.001
Brugia malayi sulfakinin receptor protein 0.0008 0.0012 0.0012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0009 0.0016 0.0006
Trichomonas vaginalis thymidine kinase, putative 0.0244 0.0807 0.0807
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0012 0.0022
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0012 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0069 0.0059
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0061 0.019 0.2311
Brugia malayi RNA, U transporter 1 0.0082 0.0263 0.0263
Schistosoma mansoni opsin-like receptor 0.0008 0.0012 0.0022
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0015 0.0027
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0028 0.0024
Plasmodium vivax copper-transporting ATPase, putative 0.0009 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Onchocerca volvulus 0.0007 0.001 0.0017
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0034 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Entamoeba histolytica steroid 5-alpha reductase, putative 0.297 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Echinococcus multilocularis dna polymerase eta 0.0041 0.0122 0.0215
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0013
Onchocerca volvulus 0.0008 0.0012 0.0022
Leishmania major P-type H -ATPase, putative 0.0009 0.0015 0.0011
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0034 0.003
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0076
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0015 0.0027
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0009 0.0016 0.0006
Schistosoma mansoni cpg binding protein 0.002 0.0053 0.0094
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0009 0.0016 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0029
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0014 0.0034 0.0059
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0249
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0009 0.0015 0.0005
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.001 0.0043
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0085 0.0273 0.0273
Echinococcus multilocularis somatostatin receptor 0.0008 0.0012 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi beta-lactamase family protein 0.0038 0.0113 0.0113
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1687 0.5672 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0057
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0048 1
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0017 0.0029
Brugia malayi Melatonin receptor type 1A 0.0008 0.0012 0.0012
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0007 0.001 0.0017
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.0708 0.0699
Schistosoma mansoni ran 0.0021 0.0057 0.0101
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0015 0.0005
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0015 0.0005
Brugia malayi ecdysteroid receptor 0.0009 0.0017 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0243
Leishmania major copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0011
Echinococcus multilocularis serotonin receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0076 0.0135
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0002 0.0004
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0015 0.0014
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0009 0.0016
Echinococcus granulosus thioredoxin glutathione reductase 0.0027 0.0076 0.0134
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Giardia lamblia Sgs1 DNA helicase, putative 0.0014 0.0034 0.0036
Schistosoma mansoni DNA helicase recq5 0.0014 0.0034 0.0059
Plasmodium falciparum copper-transporting ATPase 0.0009 0.0015 0.002
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.001 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0113 0.0103
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0012 0.0012
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.001 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0017 0.0029
Mycobacterium ulcerans hypothetical protein 0.0038 0.0113 0.0103
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0067 0.0212 0.2599
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0017 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Onchocerca volvulus 0.0008 0.0012 0.0022
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.297 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni myo inositol monophosphatase 0.0008 0.0013 0.0023
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0008 0.0013 0.0023
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0009 0.0016 0.0013
Onchocerca volvulus 0.0007 0.001 0.0017
Leishmania major myo-inositol-1 phosphatase, putative 0.0008 0.0013 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0017 0.0029
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0069 0.276
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0017 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0101 0.0325 0.0325
Trypanosoma brucei unspecified product 0.0041 0.0122 0.0118
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0013 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0002 0.0002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.0012 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni carbonic anhydrase 0.0101 0.0325 0.0572
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0005 0.0001 0.0002
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0015 0.0027
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0015 0.0015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0252 0.0249
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0012 0.0022
Leishmania major trypanothione reductase 0.0027 0.0075 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.0012 0.0022
Giardia lamblia DINP protein human, muc B family 0.0041 0.0122 0.0192
Loa Loa (eye worm) glutathione reductase 0.0027 0.0075 0.0075
Echinococcus multilocularis muscleblind protein 0.0157 0.0514 0.0905
Echinococcus granulosus allatostatin A receptor 0.0008 0.0012 0.0022
Plasmodium vivax polyprenol reductase, putative 0.1687 0.5672 1
Schistosoma mansoni eyes absent homolog 0.0092 0.0297 0.0523
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0009 0.0015 0.0011
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.001 0.0043
Echinococcus granulosus serotonin receptor 0.0008 0.0012 0.0022
Schistosoma mansoni importin beta-1 0.0029 0.0083 0.0146
Loa Loa (eye worm) beta-lactamase 0.0038 0.0113 0.0113
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0014 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0009 0.0015 0.002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0048 0.0523
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0012 0.0022
Schistosoma mansoni zinc finger protein 0.0005 0.0001 0.0002
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0009 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi Inositol-1 0.0079 0.0252 0.0252
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.134
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0252 0.0249
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Plasmodium falciparum thioredoxin reductase 0.0027 0.0075 0.0125
Brugia malayi G-protein coupled receptor 0.0008 0.0012 0.0012
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0118 0.0115
Trichomonas vaginalis hypothetical protein 0.0005 0.0004 0.0003
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0011
Schistosoma mansoni inositol monophosphatase 0.0079 0.0252 0.0445
Brugia malayi Dopamine receptor protein 2 0.0008 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Onchocerca volvulus 0.002 0.0053 0.0094
Echinococcus multilocularis G protein coupled receptor 139 0.0008 0.0012 0.0022
Trypanosoma cruzi thymidine kinase, putative 0.0244 0.0807 0.0798
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0067 0.0212 0.9436
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0005 0.0002 0.0004
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0064 0.0055
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0012 0.0022
Entamoeba histolytica hypothetical protein 0.1687 0.5672 0.5671
Brugia malayi glutathione reductase 0.0027 0.0075 0.0075
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0008 0.0012 0.0022
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Onchocerca volvulus 0.0008 0.0012 0.0022
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0015 0.0015
Leishmania major proton motive ATPase, putative 0.0009 0.0015 0.0011
Schistosoma mansoni myosin xvIII 0.0008 0.0012 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0064 0.0202 0.0202
Echinococcus granulosus fmrfamide receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus importin subunit beta 1 0.0029 0.0083 0.0146
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0113 0.0103
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0015 0.0011
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0008 0.0013 0.0003
Trypanosoma brucei thymidine kinase 0.0244 0.0807 0.0804
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0009 0.0015 0.0246
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0017 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0012 0.0022
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0113 0.0198
Echinococcus granulosus inositol monophosphatase 0.0008 0.0013 0.0023
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0017 0.0017
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0057
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0015 0.0015
Echinococcus multilocularis transportin 1 0.0005 0.0004 0.0007
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0028 0.0018
Brugia malayi F/Y-rich N-terminus family protein 0.0006 0.0006 0.0006
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.0012 0.0022
Plasmodium falciparum carbonic anhydrase 0.0101 0.0325 0.0566
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0015 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0113 0.134
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0085 0.0273 0.0273
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0067 0.0212 0.2599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0017 0.0017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0028 0.0024
Loa Loa (eye worm) acetyltransferase 0.0147 0.0479 0.0479
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0017 0.0029
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0012 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0076
Mycobacterium leprae Probable lipase LipE 0.0038 0.0113 0.4786
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Schistosoma mansoni cpg binding protein 0.0021 0.0057 0.0101
Loa Loa (eye worm) oxidoreductase 0.0007 0.001 0.001
Brugia malayi G protein-coupled receptor 0.0008 0.0012 0.0012
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.0012 0.0022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Plasmodium falciparum polyprenol reductase, putative 0.1687 0.5672 1
Brugia malayi larval opioid receptor 0.0008 0.0012 0.0012
Echinococcus granulosus muscleblind protein 0.0157 0.0514 0.0905
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0038 0.0113 0.0198
Echinococcus granulosus snurportin 1 0.0309 0.1028 0.1813
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Brugia malayi kap beta 3 protein 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0017 0.0029
Brugia malayi steroid hormone receptor 0.0009 0.0017 0.0017
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0057 0.0053
Brugia malayi CXXC zinc finger family protein 0.002 0.0053 0.0053
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0122 0.0215
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0113 0.0109
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.0708 0.0704
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni opsin-like receptor 0.0008 0.0012 0.0022
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0012 0.0022
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0015 0.0027
Schistosoma mansoni cpg binding protein 0.0021 0.0057 0.0101
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0015 0.0011
Schistosoma mansoni adenoreceptor 0.0008 0.0012 0.0022
Brugia malayi Synaptic glycoprotein SC2 0.1687 0.5672 0.5672
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0016 0.0006
Brugia malayi G-protein coupled receptor 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0069
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0009 0.0015 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0069 0.0059
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0028 0.0024
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0252 0.0243
Schistosoma mansoni biogenic amine receptor 0.0008 0.0012 0.0022
Brugia malayi GnHR receptor homolog 0.0008 0.0012 0.0012
Echinococcus granulosus synaptic glycoprotein sc2 0.1687 0.5672 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0017 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1666 0.5601 0.9875
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0028 0.0018
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis importin 5 0.0005 0.0004 0.0007
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0092 0.0297 0.0297
Schistosoma mansoni hypothetical protein 0.0138 0.045 0.0794
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0034 0.0024
Brugia malayi Serotonin receptor 0.0008 0.0012 0.0012
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0015 0.0027
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0017 0.0017
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0113 0.134
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0122 0.0122
Trichomonas vaginalis mercuric reductase, putative 0.0009 0.0016 0.0016
Schistosoma mansoni biogenic amine receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0074
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0012 0.0022
Echinococcus granulosus neuropeptide receptor 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0113 0.134
Entamoeba histolytica thymidine kinase, putative 0.0244 0.0807 0.0804
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0069 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Loa Loa (eye worm) hypothetical protein 0.0058 0.0182 0.0182
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0122 0.0215
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.001 0.0043
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi Dopamine receptor protein 1 0.0008 0.0012 0.0012
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0009 0.0016 0.0013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0017 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0017 0.0017
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0012 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0017 0.0029
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0122 0.0112
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0025 0.0044
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0009 0.0015 0.011
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0015 0.0027
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0015 0.0027
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0118 0.0186
Echinococcus multilocularis sex peptide receptor 0.0008 0.0012 0.0022
Giardia lamblia Synaptic glycoprotein SC2 0.1687 0.5672 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0069 0.0791
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0015 0.0027
Schistosoma mansoni opsin-like receptor 0.0008 0.0012 0.0022
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0048 0.0078
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0008 0.0013 0.0158
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0007 0.0008 0.0008
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0004 0.0004
Brugia malayi Importin beta-1 subunit 0.0029 0.0083 0.0083
Toxoplasma gondii ABC1 family protein 0.0038 0.0113 0.0109
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0009 0.0015 0.011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0069 0.0065
Trichomonas vaginalis ran, putative 0.0021 0.0057 0.0057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0012 0.0022
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Toxoplasma gondii P-type ATPase4, putative 0.0009 0.0015 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0012 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0013
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0012 0.0012
Echinococcus granulosus cpg binding protein 0.0021 0.0057 0.0101
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.1687 0.5672 0.5671
Onchocerca volvulus 0.0008 0.0012 0.0022
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0028 0.0042
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0006
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.297 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0202 0.0356
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.1687 0.5672 1
Echinococcus granulosus carbonic anhydrase 0.0101 0.0325 0.0572
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0017 0.0029
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0325 0.0325
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Mycobacterium tuberculosis Probable dehydrogenase 0.0061 0.019 0.2311
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0202 0.0356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.1028 0.1028
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0015 0.0015
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0479 0.0479
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.001 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0085 0.0273 0.0273
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.0182 0.0182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0009 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0122 0.0122
Echinococcus granulosus g protein coupled receptor 0.0008 0.0012 0.0022
Brugia malayi beta-lactamase family protein 0.0038 0.0113 0.0113
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0076 0.0135
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0017 0.0029
Onchocerca volvulus 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0113 0.134
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0034 0.0034
Loa Loa (eye worm) calcium ATPase 0.0009 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0017 0.0017
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1687 0.5672 0.5672
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0061 0.019 0.8374
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0017 0.0017
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0202 0.0356
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0015 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0017 0.0029
Schistosoma mansoni hypothetical protein 0.0101 0.0325 0.0572
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.001 0.0006
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0012 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0157 0.0514 0.0514
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0008 0.0013 0.0023
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0009 0.0015 0.0005
Trichomonas vaginalis thymidine kinase, putative 0.0244 0.0807 0.0807
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.0034
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0008 0.0013 0.001
Onchocerca volvulus 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.134
Plasmodium falciparum thioredoxin reductase 0.0009 0.0016 0.0022
Schistosoma mansoni histamine h1 receptor 0.0008 0.0012 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0799 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0076
Schistosoma mansoni ran 0.0021 0.0057 0.0101
Treponema pallidum NADH oxidase 0.0009 0.0016 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0075 0.0065
Schistosoma mansoni inositol monophosphatase 0.0079 0.0252 0.0445
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0074 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0012 0.0022
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0028 0.0042
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0009 0.0015 0.011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0113 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.001 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0122 0.0215
Schistosoma mansoni biogenic amine receptor 0.0008 0.0012 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0076 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0017 0.0029
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0131 0.023
Schistosoma mansoni pap-inositol-14-phosphatase 0.0008 0.0013 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0017 0.0017
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0325 0.0572
Loa Loa (eye worm) hypothetical protein 0.297 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0069 0.0791
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0012 0.0022
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0009 0.0016 0.0876
Onchocerca volvulus 0.1687 0.5672 1
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0034 0.0033
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0015 0.0015
Echinococcus granulosus g-protein coupled receptor 0.0008 0.0012 0.0022
Plasmodium falciparum importin beta, putative 0.0029 0.0083 0.014
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0012 0.0022
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0113 0.0192
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0015 0.0027
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0131 0.013
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0012 0.0012
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.0708 0.0708
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0034 0.003
Schistosoma mansoni DNA helicase recq1 0.0014 0.0034 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0122 0.0118
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1687 0.5672 0.5671
Echinococcus multilocularis cpg binding protein 0.0021 0.0057 0.0101
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0009 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.001 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0015 0.0027
Echinococcus multilocularis GPCR, family 2 0.0027 0.0076 0.0135
Plasmodium vivax glutathione reductase, putative 0.0027 0.0075 0.0125
Onchocerca volvulus 0.0008 0.0012 0.0022
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable monophosphatase 0.0008 0.0013 0.0086
Echinococcus granulosus zinc finger protein 0.0005 0.0001 0.0002
Brugia malayi nuclear receptor NHR-88 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Onchocerca volvulus 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0008 0.0012 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0069 0.0059
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0012 0.0012
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.001 0.0006
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0002 0.0002
Echinococcus granulosus translational activator gcn1 0.0005 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi nuclear hormone receptor 0.0009 0.0017 0.0017
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0012 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0009 0.0016 0.0013
Leishmania major DNA polymerase eta, putative 0.0041 0.0122 0.0118
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0012 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.1687 0.5672 0.5672
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0015 0.0027
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.0708 0.1248
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0008 0.0013 0.0003
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0122 0.0215
Onchocerca volvulus 0.0007 0.001 0.0017
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0015 0.0027
Schistosoma mansoni ATPase 0.0009 0.0015 0.0027
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.0012 0.0022
Echinococcus granulosus neuropeptide receptor 0.0008 0.0012 0.0022
Schistosoma mansoni importin-beta 2 0.0005 0.0004 0.0007
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.0708 0.1248
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0008 0.0013 0.0023
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.001 0.0011
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0015 0.0011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.0012 0.0022
Brugia malayi putative neuropeptide receptor 0.0008 0.0012 0.0012
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0224 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0325 0.0325
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0002 0.0003
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0013 0.0013
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0013 0.0013
Giardia lamblia Copper-transporting P-type ATPase 0.0009 0.0015 0.0003
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0015 0.0011
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0015 0.0015
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.001 0.0017
Plasmodium vivax P-type ATPase4, putative 0.0009 0.0015 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0006 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0017 0.0017
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0252 0.0252
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0012 0.0012
Entamoeba histolytica Ran family GTPase 0.0021 0.0057 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0009 0.0015 0.011
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0008 0.0013 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus granulosus sex peptide receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0126 0.0123
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis allatostatin A receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0017 0.0017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0069 0.0065
Loa Loa (eye worm) inositol-1 0.0079 0.0252 0.0252
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0015 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0113 0.134
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0122 0.0121
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0083 0.0079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0061 0.019 0.2311
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0044
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0012 0.0022
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.1687 0.5672 0.5671
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.001 0.0017
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0012 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0017 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0061
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.0513 0.1714 0.3022
Brugia malayi Serotonin receptor 0.0008 0.0012 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0016 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0014 0.0034 0.0053
Echinococcus granulosus g protein coupled receptor 0.0008 0.0012 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0028 0.0024
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0015 0.0027
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Brugia malayi nuclear receptor RXR 0.0005 0.0002 0.0002
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0034 0.0059
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0224 0.2752
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0069 0.0065
Trichomonas vaginalis glutathione reductase, putative 0.0009 0.0016 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0113 0.0198
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1687 0.5672 0.5671
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.001 0.0043
Onchocerca volvulus 0.0008 0.0012 0.0022
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0015 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0122 0.0112
Onchocerca volvulus 0.0008 0.0012 0.0022
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.0009
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0069 0.0059
Trypanosoma cruzi trypanothione reductase, putative 0.0009 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0092 0.0297 0.0297
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0064 0.0064
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0325 0.0572
Giardia lamblia NADH oxidase lateral transfer candidate 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi AKH receptor 0.0008 0.0012 0.0012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0122 0.0122
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0061 0.019 0.2311
Loa Loa (eye worm) thioredoxin reductase 0.0027 0.0075 0.0075
Trypanosoma brucei trypanothione reductase 0.0027 0.0075 0.0071
Echinococcus multilocularis snurportin 1 0.0309 0.1028 0.1813
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0017 0.0029
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0479 0.0845
Loa Loa (eye worm) hypothetical protein 0.0157 0.0514 0.0514
Schistosoma mansoni hypothetical protein 0.0058 0.0182 0.0321
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.0012 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Leishmania major DNA damage repair protein, putative 0.0013 0.0028 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0122 0.0118
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0009 0.0016 0.0016
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0015 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0017 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0112
Loa Loa (eye worm) RecQ helicase 0.0014 0.0034 0.0034
Plasmodium vivax calcium-transporting ATPase, putative 0.0009 0.0015 0.002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0325 0.0325
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0325 0.0572
Brugia malayi hypothetical protein 0.0026 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.001 0.0006
Loa Loa (eye worm) histone methyltransferase 0.0006 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.0012 0.0022
Brugia malayi neuropeptide F receptor 0.0008 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0131 0.0127
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0076
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1687 0.5672 0.5672
Schistosoma mansoni hypothetical protein 0.0309 0.1028 0.1813
Onchocerca volvulus 0.0038 0.0113 0.0198
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0017 0.0029
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0007 0.0008 0.0008
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0012 0.0012
Echinococcus granulosus dna polymerase eta 0.0041 0.0122 0.0215
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0243
Mycobacterium ulcerans beta-lactamase 0.0038 0.0113 0.0103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Entamoeba histolytica recQ family DNA helicase 0.0007 0.001 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0076 0.0076
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0015 0.0011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0012 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0113 0.0198
Onchocerca volvulus Neuropeptide F receptor homolog 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0015 0.0015
Onchocerca volvulus 0.0025 0.0069 0.0122
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0012 0.0012
Echinococcus granulosus transportin 1 0.0005 0.0004 0.0007
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.0325 0.0325
Trypanosoma brucei RNA helicase, putative 0.0138 0.045 0.0447
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0017 0.0029
Onchocerca volvulus 0.0008 0.0012 0.0022
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0009 0.0015 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0012 0.0012
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0015 0.0027
Entamoeba histolytica recQ family helicase, putative 0.0007 0.0009 0.0005
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0013 0.0013
Echinococcus granulosus GPCR family 2 0.0027 0.0076 0.0135
Trichomonas vaginalis esterase, putative 0.0038 0.0113 0.0112
Schistosoma mansoni bromodomain containing protein 0.0005 0.0001 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0009 0.0016 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0001 0.000000000019982
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0002 0.0004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0057 0.0101
Echinococcus multilocularis synaptic glycoprotein sc2 0.1687 0.5672 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0048 0.0078
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0009 0.0015 0.0011
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0101 0.0325 0.0325
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0009 0.0015 0.011
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0012 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0017 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0013
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0514 0.0905
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0118 0.0202
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0028 0.0024
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0479 0.0845
Echinococcus multilocularis neuropeptide receptor A26 0.0513 0.1714 0.3022
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0011
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.0708 0.0708
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0012 0.0022
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0009 0.0015 0.0005
Onchocerca volvulus 0.0038 0.0113 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0017 0.0017
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.0034 0.0053
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0012 0.0012
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0007 0.0009 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0113 0.0112
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.0708 0.1248
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Monophosphatase CysQ 0.0008 0.0013 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0202 0.0356
Plasmodium vivax cation transporting ATPase, putative 0.0009 0.0015 0.002
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.001 0.0006
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0.0015 0.8189
Onchocerca volvulus 0.0008 0.0012 0.0022
Leishmania major importin beta-1 subunit, putative 0.0023 0.0064 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0129 0.0228
Leishmania major hypothetical protein, conserved 0.0038 0.0113 0.0109
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0325 0.0325
Echinococcus granulosus carbonic anhydrase II 0.0214 0.0708 0.1248
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Leishmania major carbonic anhydrase-like protein 0.0214 0.0708 0.0704
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 0.5672
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0074 0.0125
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0015 0.0015
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0015 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0034 0.0033
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0012 0.0022
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0252 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.297 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0513 0.1714 0.3022
Echinococcus granulosus neuropeptide s receptor 0.0513 0.1714 0.3022
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.0012 0.0022
Echinococcus granulosus somatostatin receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0015 0.0015
Toxoplasma gondii hypothetical protein 0.0008 0.0013 0.001
Giardia lamblia DNA damage repair protein 0.0013 0.0028 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0122 0.1459
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Plasmodium vivax thioredoxin reductase, putative 0.0027 0.0075 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0064
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0015 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1687 0.5672 0.5672
Mycobacterium ulcerans monophosphatase 0.0008 0.0013 0.0003
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0028 0.0049
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0112
Mycobacterium ulcerans hypothetical protein 0.0025 0.0069 0.0059
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0202 0.0356
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Mycobacterium leprae Probable monophosphatase 0.0008 0.0013 0.0158
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0048 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0017 0.0017
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0094
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0015 0.0014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0113 0.0113
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0017 0.0029
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0009 0.0015 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0202 0.0356
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0014 0.0034 0.0059
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0047
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.001 0.0000079012
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0015 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0002 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0074 0.0071
Brugia malayi ORL1-like opioid receptor 0.0008 0.0012 0.0012
Brugia malayi RE15519p 0.0008 0.0012 0.0012
Trypanosoma brucei unspecified product 0.0028 0.008 0.0076
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0085 0.0273 0.0273
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1687 0.5672 0.5672
Echinococcus multilocularis translational activator gcn1 0.0005 0.0004 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0017 0.0029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0061 0.019 0.2311
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0009 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0015 0.0027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0252 0.0252
Brugia malayi PHD-finger family protein 0.0005 0.0001 0.0001
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0014 0.0034 0.0059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0034
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0029
Plasmodium falciparum glutathione reductase 0.0009 0.0016 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0012 0.0022
Schistosoma mansoni hypothetical protein 0.0008 0.0013 0.0023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0012 0.0022
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 1
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0028 0.0024
Mycobacterium tuberculosis Probable reductase 0.0061 0.019 0.2311
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0009 0.0015 0.0246
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0015 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1687 0.5672 0.5672
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0008 0.0012 0.0022
Echinococcus granulosus g protein coupled receptor 0.0008 0.0012 0.0022
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 0.5668
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0012 0.0022
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0014 0.0034 0.0059
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0122 0.0112
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0009 0.0015 0.0005
Leishmania major DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0012 0.0012
Leishmania major thymidine kinase, putative 0.0244 0.0807 0.0804
Echinococcus granulosus importin 5 0.0005 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0008 0.0013 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0083
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0012 0.0012
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0131 0.013
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0009 0.0015 0.0246
Echinococcus granulosus hypothetical protein 0.0008 0.0012 0.0022
Schistosoma mansoni bromodomain containing protein 0.0005 0.0001 0.0002
Schistosoma mansoni DNA polymerase eta 0.0041 0.0122 0.0215
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0017 0.0017
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0113 0.134
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0252 0.0252
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0113 0.134
Toxoplasma gondii thioredoxin reductase 0.0027 0.0075 0.0071
Plasmodium vivax importin-beta 2, putative 0.0029 0.0083 0.014
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0025 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0017 0.0017
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0009 0.0015 0.0011
Giardia lamblia Thymidine kinase 0.0244 0.0807 0.1403
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0076 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0074 0.0125
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0074 0.0125
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0017 0.0017
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.134
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0112
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Onchocerca volvulus 0.0008 0.0012 0.0022
Mycobacterium ulcerans hypothetical protein 0.297 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0012 0.0022
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0325 0.0572
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0017 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0122 0.0118
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0015 0.0027
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1687 0.5672 1
Onchocerca volvulus 0.0008 0.0012 0.0022
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0008 0.0013 0.001
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.0009
Onchocerca volvulus 0.0009 0.0015 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0113 0.4786
Schistosoma mansoni ATPase 0.0009 0.0015 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0074 0.0065
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0015 0.0011
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.001 0.0043
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0015 0.0014
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0012 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0069 0.0065
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0009 0.0017 0.0029
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0122 0.1459
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0017 0.0029
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0011
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0015 0.0011
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Echinococcus multilocularis inositol monophosphatase 0.0008 0.0013 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0122 0.0118
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0015 0.0011
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.0012 0.0022
Brugia malayi Bromodomain containing protein 0.0005 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Schistosoma mansoni coup transcription factor 0.0009 0.0017 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.0005 0.0002 0.0004
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0028 0.0018
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0249
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0034 0.003
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0028 0.0018
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0009 0.0015 0.0011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0465 0.0821
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0083 0.0146
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0009 0.0015 0.0005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0017 0.0017
Trypanosoma cruzi thymidine kinase, putative 0.0244 0.0807 0.0798
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.0012 0.0022
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0027 0.0076 0.0134
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0069 0.276
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0013 0.001
Brugia malayi polk-prov protein 0.0013 0.0028 0.0028
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0009 0.0016 0.0013
Brugia malayi Muscleblind-like protein 0.0157 0.0514 0.0514
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.0012 0.0022
Trypanosoma brucei cation-transporting ATPase, putative 0.0009 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0008 0.0013 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0047
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0009 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0057 0.0101
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0002 0.0003
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.0708 0.0699
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0252 0.0445
Toxoplasma gondii cation-transporting atpase family protein 0.0009 0.0015 0.0011
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.0012 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0009 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0113 0.0112
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0012 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0009 0.0016 0.0022
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.0012 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0017 0.0029
Leishmania major hypothetical protein, conserved 0.0026 0.0074 0.0071
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0122 0.0122
Trypanosoma cruzi DNA polymerase eta, putative 0.0013 0.0028 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.003
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0101 0.0325 0.0325
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0113 0.0113
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0028 0.0024
Mycobacterium ulcerans lipase LipD 0.0038 0.0113 0.0103
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0069
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Leishmania major calcium-translocating P-type ATPase 0.0009 0.0015 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0005 0.0001 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0076 0.0135
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.001 0.0000079012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi hypothetical protein 0.0009 0.0015 0.0015
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Brugia malayi beta-lactamase 0.0038 0.0113 0.0113
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.1687 0.5672 1
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0252 0.0445
Toxoplasma gondii hypothetical protein 0.0101 0.0325 0.0321
Loa Loa (eye worm) hypothetical protein 0.1687 0.5672 0.5672
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0008 0.0013 0.0013
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0122 0.0121
Echinococcus granulosus carbonic anhydrase 0.0101 0.0325 0.0572
Plasmodium falciparum glutathione reductase 0.0027 0.0075 0.0125
Mycobacterium ulcerans hypothetical protein 0.0013 0.0028 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0074 0.0065
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0017 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0064 0.0202 0.0202
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.0012 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.001 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0012 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0113 0.0198
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.001 0.0011
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0013 0.0013
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0009 0.0015 0.0011
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0009 0.0015 0.0005
Leishmania major P-type H -ATPase, putative 0.0009 0.0015 0.0011
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0057 0.0094
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0076 0.0076
Toxoplasma gondii NADPH-glutathione reductase 0.0009 0.0016 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0325 0.0572
Echinococcus granulosus dna polymerase kappa 0.0041 0.0122 0.0215
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0028 0.0024

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 78 nM Inhibitory activity against human carbonic anhydrase IX ChEMBL. 15012984
Ki (binding) = 78 nM Inhibitory activity against human carbonic anhydrase IX ChEMBL. 15012984
Ki (binding) = 350 nM Inhibitory activity against human carbonic anhydrase II ChEMBL. 15012984
Ki (binding) = 350 nM Inhibitory activity against human carbonic anhydrase II ChEMBL. 15012984
Ki (binding) = 864 nM Inhibitory activity of the compound against carbonic anhydrase IV from bovine lung microsomes ChEMBL. 15012984
Ki (binding) = 864 nM Inhibitory activity of the compound against carbonic anhydrase IV from bovine lung microsomes ChEMBL. 15012984
Ki (binding) = 94 uM Inhibitory activity against human carbonic anhydrase I ChEMBL. 15012984
Ki (binding) = 94 uM Inhibitory activity against human carbonic anhydrase I ChEMBL. 15012984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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