Detailed information for compound 29111

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.352 | Formula: C17H21NO5
  • H donors: 1 H acceptors: 4 LogP: 2 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1Cc2c(N1C(=O)CCC(C(=O)O)C)cccc2
  • InChi: 1S/C17H21NO5/c1-3-23-17(22)14-10-12-6-4-5-7-13(12)18(14)15(19)9-8-11(2)16(20)21/h4-7,11,14H,3,8-10H2,1-2H3,(H,20,21)
  • InChiKey: HSWKRUJJVQSUAB-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0281 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.007 0.0281 0.065
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.007 0.0281 0.065
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0682
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.047 0.0456
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0505 0.2645 0.8704
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.007 0.0281 1
Brugia malayi Angiotensin-converting enzyme family protein 0.0749 0.3973 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0505 0.2645 0.8704
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0091 0.0034
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.015 0.0203
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0574 0.3026 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Echinococcus multilocularis geminin 0.0164 0.0794 0.2396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0682
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0505 0.2645 0.6589
Leishmania major hypothetical protein, conserved 0.007 0.0281 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0235 0.0491
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0281 0.065
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.047 0.0456
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.007 0.0281 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0523 0.2748 0.9082
Leishmania major hypothetical protein, conserved 0.007 0.0281 1
Plasmodium vivax phosphodiesterase gamma, putative 0.007 0.0281 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0281 1
Echinococcus granulosus tar DNA binding protein 0.0061 0.0235 0.0491
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0164 0.0214
Brugia malayi hypothetical protein 0.0035 0.0091 0.0026
Giardia lamblia hypothetical protein 0.007 0.0281 0.0929
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0505 0.2645 0.6589
Loa Loa (eye worm) hypothetical protein 0.007 0.0281 0.0516
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.047 0.0456
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0574 0.3026 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0235 0.0396
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.007 0.0281 0.0516
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.015 0.0203
Loa Loa (eye worm) PDE1B protein 0.007 0.0281 0.0516
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0164 0.0214
Echinococcus granulosus geminin 0.0164 0.0794 0.2396
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0281 0.0516
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0533 0.0095
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0533 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.007 0.0281 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.007 0.0281 0.065
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0281 1
Schistosoma mansoni hypothetical protein 0.0164 0.0794 0.2422
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0164 0.0214
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0235 0.0396
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0574 0.3026 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.007 0.0281 0.0516
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0164 0.0214
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.007 0.0281 0.065
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0 0.0017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0235 0.0396
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.053 0.1155
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0281 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.015 0.0495
Plasmodium falciparum phosphodiesterase gamma, putative 0.007 0.0281 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.015 0.0179
Brugia malayi MH2 domain containing protein 0.0116 0.053 0.1155
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0533 0.0546
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.007 0.0281 0.065
Giardia lamblia Hypothetical protein 0.007 0.0281 0.0929
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0281 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1333 0.7153 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.053 0.1155
Schistosoma mansoni hypothetical protein 0.0164 0.0794 0.2422
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0523 0.2748 0.3409
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.007 0.0281 0.065
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0574 0.3026 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.007 0.0281 0.065
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0682
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0 0.0017
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0574 0.3026 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 0.3973 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1333 0.7153 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0281 0.065
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Loa Loa (eye worm) hypothetical protein 0.007 0.0281 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0281 0.065
Schistosoma mansoni hypothetical protein 0.0035 0.0091 0.0034
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0281 0.0516
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.015 0.0179
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0281 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi Thioredoxin reductase 0.0046 0.015 0.0179
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.007 0.0281 0.065
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0281 0.065
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Loa Loa (eye worm) RNA binding protein 0.0061 0.0235 0.0396
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.007 0.0281 0.0516
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0281 1
Plasmodium falciparum phosphodiesterase delta, putative 0.007 0.0281 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0533 0.0546
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0574 0.3026 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 1
Loa Loa (eye worm) hypothetical protein 0.0574 0.3026 0.7566
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi glutathione reductase 0.0046 0.015 0.0179
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.047 0.0456
Trichomonas vaginalis MYB, putative 0.0018 0 0.0017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi TAR-binding protein 0.0061 0.0235 0.0396
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0516
Loa Loa (eye worm) hypothetical protein 0.007 0.0281 0.0516
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0281 0.0516
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0574 0.3026 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.047 0.0456
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Brugia malayi RNA binding protein 0.0061 0.0235 0.0396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.047 0.0456

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 170000 nM In vitro inhibition of angiotensin I converting enzyme (ACE) ChEMBL. 6310113
IC50 (binding) = 170000 nM In vitro inhibition of angiotensin I converting enzyme (ACE) ChEMBL. 6310113
Inhibition (functional) = 11 % Invivo percent inhibition of angiotensin I pressor response 15 min after 10mg/kg, iv administration in spontaneously hypertensive rat (SHR) ChEMBL. 6310113

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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