TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 413.507 | Formula: C24H31NO5
H donors: 3 H acceptors: 4 LogP: 6.67 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CC(CCCC(C)C)CCOC(=O)c1cc(/N=C/c2cc(O)ccc2O)ccc1O
InChi: 1S/C24H31NO5/c1-16(2)5-4-6-17(3)11-12-30-24(29)21-14-19(7-9-23(21)28)25-15-18-13-20(26)8-10-22(18)27/h7-10,13-17,26-28H,4-6,11-12H2,1-3H3/b25-15+
InChiKey: GUYITFKMGQHYEN-MFKUBSTISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Schistosoma mansoni	tyrosine kinase	0.0097	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0118	0.0242	0.0242
Echinococcus multilocularis	glycine receptor subunit beta	0.0118	0.0242	0.0242
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0012	0.0012
Echinococcus multilocularis	thymidylate synthase	0.1302	0.4173	0.4173
Loa Loa (eye worm)	TK/INSR protein kinase	0.0058	0.004	0.004
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.2843	0.929	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0058	0.004	0.004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118	0.0242	0.0242
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0118	0.0242	0.0242
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0118	0.0242	0.0242
Echinococcus multilocularis	glycine receptor subunit beta	0.0118	0.0242	0.0242
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0012	0.0012
Echinococcus granulosus	glycine receptor subunit beta	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Echinococcus granulosus	geminin	0.0166	0.04	0.04
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0012	0.0012
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.0447	0.0447
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0118	0.0242	0.0242
Echinococcus multilocularis	dihydrofolate reductase	0.3057	1	1
Onchocerca volvulus		0.0118	0.0242	0.058
Brugia malayi	thymidylate synthase	0.1302	0.4173	0.4173
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0118	0.0242	0.0242
Echinococcus multilocularis	insulin receptor	0.0058	0.004	0.004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0012	0.0012
Schistosoma mansoni	nAChR subunit	0.0118	0.0242	0.0242
Onchocerca volvulus		0.0118	0.0242	0.058
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0118	0.0242	0.0242
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0118	0.0242	0.0242
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0118	0.0242	0.0242
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0118	0.0242	0.0242
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0073	0.0091	0.0091
Onchocerca volvulus		0.0073	0.0091	0.0219
Schistosoma mansoni	neurotransmitter gated ion channel	0.0073	0.0091	0.0091
Echinococcus multilocularis	geminin	0.0166	0.04	0.04
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0118	0.0242	0.0242
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.3057	1	1
Onchocerca volvulus		0.0118	0.0242	0.058
Schistosoma mansoni	nAChR subunit	0.0118	0.0242	0.0242
Onchocerca volvulus	Putative nachr subunit	0.0118	0.0242	0.058
Schistosoma mansoni	tyrosine kinase	0.0097	0.017	0.017
Onchocerca volvulus		0.0147	0.0339	0.0812
Schistosoma mansoni	tyrosine kinase	0.0058	0.004	0.004
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0118	0.0242	0.0242
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0012	0.0012
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.2843	0.929	0.5
Echinococcus granulosus	nAChR subunit	0.0073	0.0091	0.0091
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0012	0.0012
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0236	0.0236
Onchocerca volvulus		0.0118	0.0242	0.058
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0058	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.3057	1	1
Schistosoma mansoni	nAChR subunit	0.0118	0.0242	0.0242
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0012	0.0012
Echinococcus granulosus	dihydrofolate reductase	0.3057	1	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0118	0.0242	0.0242
Loa Loa (eye worm)	GABA receptor subunit	0.0073	0.0091	0.0091
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1302	0.4173	0.2801
Schistosoma mansoni	tyrosine kinase	0.0096	0.0167	0.0167
Onchocerca volvulus		0.0118	0.0242	0.058
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0073	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0118	0.0242	0.0242
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0073	0.0091	0.0091
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.3057	1	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.2843	0.929	1
Echinococcus multilocularis	nAChR subunit	0.0073	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Echinococcus granulosus	thymidylate synthase	0.1302	0.4173	0.4173
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Brugia malayi	MH2 domain containing protein	0.0116	0.0236	0.0236
Schistosoma mansoni	tyrosine kinase	0.0096	0.0167	0.0167
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118	0.0242	0.0242
Brugia malayi	hypothetical protein	0.0619	0.1906	0.1906
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0118	0.0242	0.0242
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0118	0.0242	0.0242
Brugia malayi	excitatory GABA receptor EXP-1A	0.0118	0.0242	0.0242
Loa Loa (eye worm)	ACC-1 protein	0.0118	0.0242	0.0242
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0118	0.0242	0.0242
Loa Loa (eye worm)	thymidylate synthase	0.1302	0.4173	0.4173
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0118	0.0242	0.0242
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0118	0.0242	0.0242
Brugia malayi	Protein kinase domain containing protein	0.0058	0.004	0.004
Brugia malayi	Cation transporter family protein	0.0118	0.0242	0.0242
Schistosoma mansoni	nAChR subunit	0.0118	0.0242	0.0242
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0118	0.0242	0.0242
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1302	0.4173	0.4173
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.2843	0.929	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.0447	0.0447
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0073	0.0091	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0619	0.1906	0.5
Schistosoma mansoni	dihydrofolate reductase	0.3057	1	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0118	0.0242	0.0242
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0118	0.0242	0.0242
Loa Loa (eye worm)	ACC-1 protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Brugia malayi	Dihydrofolate reductase	0.3057	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.0447	0.0447
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0118	0.0242	0.0242
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.017	0.017
Echinococcus multilocularis	nAChR subunit	0.0118	0.0242	0.0242
Schistosoma mansoni	nAChR subunit	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0166	0.04	0.04
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Schistosoma mansoni	tyrosine kinase	0.0058	0.004	0.004
Brugia malayi	Cation transporter family protein	0.0118	0.0242	0.0242
Brugia malayi	Cation transporter family protein	0.0118	0.0242	0.0242
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0118	0.0242	0.0242
Loa Loa (eye worm)	LGC-31 protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0118	0.0242	0.0242
Brugia malayi	hypothetical protein	0.0147	0.0339	0.0339
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.017	0.017
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0073	0.0091	0.0091
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118	0.0242	0.0242
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118	0.0242	0.0242
Schistosoma mansoni	nAChR subunit	0.0118	0.0242	0.0242
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.2843	0.929	0.5
Loa Loa (eye worm)	dihydrofolate reductase	0.3057	1	1
Schistosoma mansoni	tyrosine kinase	0.018	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Echinococcus granulosus	nAChR subunit	0.0118	0.0242	0.0242
Onchocerca volvulus		0.0073	0.0091	0.0219
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0339	0.0339
Echinococcus granulosus	insulin receptor	0.0058	0.004	0.004
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.0447	0.0447
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0236	0.0236
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0118	0.0242	0.0242
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.2843	0.929	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0118	0.0242	0.0242
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0118	0.0242	0.0242
Echinococcus granulosus	glycine receptor subunit beta	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Schistosoma mansoni	nAChR subunit	0.0118	0.0242	0.0242
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0118	0.0242	0.0242
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0118	0.0242	0.0242
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0118	0.0242	0.0242
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0118	0.0242	0.0242
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0118	0.0242	0.0242
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0118	0.0242	0.0242
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0118	0.0242	0.0242
Echinococcus multilocularis		0.0056	0.0034	0.0034
Onchocerca volvulus		0.0118	0.0242	0.058
Schistosoma mansoni	tyrosine kinase	0.0096	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118	0.0242	0.0242
Schistosoma mansoni	hypothetical protein	0.0166	0.04	0.04
Onchocerca volvulus		0.1302	0.4173	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.017	0.017
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0118	0.0242	0.0242
Chlamydia trachomatis	dihydrofolate reductase	0.3057	1	0.5
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0073	0.0091	0.0091
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0118	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0242	0.0242
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0118	0.0242	0.0242
Entamoeba histolytica	hypothetical protein	0.0073	0.0091	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 5 uM	Inhibition of EGF-stimulated DNA synthesis in ER22 cells, by measuring [3H]-Me-dT incorporation into ER 22 cells	ChEMBL.	8145236
IC50 (functional)	= 5 uM	Inhibition of EGF-stimulated DNA synthesis in ER22 cells, by measuring [3H]-Me-dT incorporation into ER 22 cells	ChEMBL.	8145236
Inhibition (functional)	= 20 uM	Inhibition of EGF-Receptor in ER 22 cell membrane at 10 uM	ChEMBL.	8145236
Inhibition (functional)	= 20 uM	Inhibition of EGF-Receptor in ER 22 cell membrane at 10 uM	ChEMBL.	8145236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL354301

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 291136