TDR Targets

Basic information

Technical information

TDR Targets ID: 291294
Name: N-(3-chloro-1-benzofuran-7-yl)-6-methoxy-7-(3 -morpholin-4-ylpropoxy)quinazolin-4-amine
MW: 468.933 | Formula: C24H25ClN4O4
H donors: 1 H acceptors: 2 LogP: 4.41 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(ncnc2cc1OCCCN1CCOCC1)Nc1cccc2c1occ2Cl
InChi: 1S/C24H25ClN4O4/c1-30-21-12-17-20(13-22(21)32-9-3-6-29-7-10-31-11-8-29)26-15-27-24(17)28-19-5-2-4-16-18(25)14-33-23(16)19/h2,4-5,12-15H,3,6-11H2,1H3,(H,26,27,28)
InChiKey: NARYDJIDKAGQQC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chlorobenzofuran-7-yl)-6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-amine
N-(3-chloro-7-benzofuranyl)-6-methoxy-7-(3-morpholinopropoxy)-4-quinazolinamine
(3-chlorobenzofuran-7-yl)-[6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl]amine
Benzofuran deriv. 13

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0014	0.0025	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.02	0.0976	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Schistosoma mansoni	hypothetical protein	0.0014	0.0025	0.0029
Brugia malayi	hypothetical protein	0.0095	0.0436	0.0461
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0025	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0046	0.0191	0.0235
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0095	0.0436	0.0503
Mycobacterium leprae	putative cytochrome p450	0.0014	0.0025	0.5
Mycobacterium leprae	Conserved hypothetical protein	0.0014	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Brugia malayi	nuclear receptor RXR	0.0106	0.0494	0.0522
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.02	0.0976	0.1032
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0025	0.0026
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0095	0.0436	0.0503
Brugia malayi	nuclear receptor RXR	0.0095	0.0436	0.0461
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0014	0.0025	0.5
Echinococcus granulosus	FTZ F1 alpha	0.02	0.0976	0.1124
Brugia malayi	hypothetical protein	0.0095	0.0436	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0012
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0014	0.0025	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.02	0.0976	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0047
Brugia malayi	SRC-1	0.0046	0.0191	0.0202
Loa Loa (eye worm)	steroid hormone receptor	0.02	0.0976	0.1032
Leishmania major	cytochrome p450-like protein	0.0014	0.0025	0.5
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0025	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0169	0.0207
Echinococcus granulosus	c src tyrosine kinase	0.0011	0.0012	0.0013
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0012	0.0013
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0014	0.0025	0.5
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0014	0.0025	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0106	0.0494	0.0522
Brugia malayi	photoreceptor-specific nuclear receptor	0.02	0.0976	0.1032
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0014	0.0025	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0191	0.0235
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0025	0.0026
Brugia malayi	conserved hypotetical protein	0.0095	0.0436	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.02	0.0976	0.1032
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0025	0.0026
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0025	0.0026
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0191	0.022
Onchocerca volvulus	Protein ultraspiracle homolog	0.02	0.0976	0.0565
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.02	0.0976	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0011	0.0012	0.0014
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0012	0.0013
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042	0.0169	0.0194
Brugia malayi	Steroid receptor seven-up type 2	0.02	0.0976	0.1032
Schistosoma mansoni	thyroid hormone receptor	0.02	0.0976	0.1124
Brugia malayi	Nuclear hormone receptor E75	0.0095	0.0436	0.0461
Loa Loa (eye worm)	SRC-1	0.0046	0.0191	0.0202
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0011	0.0012	0.0013
Echinococcus multilocularis	ecdysone induced protein 78C	0.02	0.0976	0.1199
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0014	0.0025	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.02	0.0976	0.1124
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0046	0.0191	0.022
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0014	0.0025	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.02	0.0976	0.1124
Schistosoma mansoni	retinoic acid receptor RXR	0.1712	0.8684	1
Leishmania major	cytochrome p450-like protein	0.0014	0.0025	0.5
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0014	0.0025	0.5
Schistosoma mansoni	tyrosine kinase	0.0011	0.0012	0.0013
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0046	0.0191	0.0235
Schistosoma mansoni	cell adhesion molecule	0.0015	0.003	0.0035
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0014	0.0025	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.02	0.0976	0.1032
Brugia malayi	Nuclear hormone receptor-like 1	0.0106	0.0494	0.0522
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0046	0.0191	0.022
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0046	0.0191	0.0235
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.02	0.0976	0.1124
Schistosoma mansoni	steroid hormone receptor ad4bp	0.02	0.0976	0.1124
Echinococcus granulosus	Immunoglobulin	0.0011	0.0012	0.0013
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0012	0.0014
Echinococcus granulosus	cytochrome P450 2K1	0.0014	0.0025	0.0029
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0025	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.0892	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Onchocerca volvulus		0.02	0.0976	0.0565
Schistosoma mansoni	coup transcription factor	0.02	0.0976	0.1124
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0014	0.0025	0.5
Brugia malayi	nuclear hormone receptor	0.02	0.0976	0.1032
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0157	0.0181
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.02	0.0976	0.1199
Schistosoma mansoni	nuclear hormone receptor	0.0095	0.0436	0.0503
Onchocerca volvulus		0.0167	0.0804	0.0384
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0012	0.0013
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0106	0.0494	0.0569
Brugia malayi	nuclear receptor NHR-67	0.0095	0.0436	0.0461
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0014	0.0025	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0095	0.0436	0.0536
Brugia malayi	tailless protein	0.0095	0.0436	0.0461
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0014	0.0025	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0095	0.0436	0.0503
Brugia malayi	Nuclear hormone receptor E75	0.0095	0.0436	0.0461
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0014	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0494	0.0522
Loa Loa (eye worm)	cytochrome P450	0.0014	0.0025	0.0026
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.02	0.0976	0.1032
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.02	0.0976	0.1032
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.02	0.0976	0.1124
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0095	0.0436	0.0536
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0014	0.0025	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0025	0.5
Leishmania major	cytochrome p450-like protein	0.0014	0.0025	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0106	0.0494	0.0522
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0014	0.0025	0.5
Brugia malayi	nuclear hormone receptor	0.1864	0.946	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.02	0.0976	0.1199
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.02	0.0976	0.1032
Onchocerca volvulus	Bile acid receptor homolog	0.02	0.0976	0.0565
Schistosoma mansoni	zinc finger protein	0.0095	0.0436	0.0503
Schistosoma mansoni	thyroid hormone receptor	0.02	0.0976	0.1124
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0014	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Brugia malayi	Nuclear hormone receptor-like 1	0.02	0.0976	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0014	0.0025	0.5
Schistosoma mansoni	cytochrome P450	0.0014	0.0025	0.0029
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0191	0.022
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0014	0.0025	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0012	0.0012
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0025	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.02	0.0976	0.1032
Brugia malayi	nuclear receptor NHR-88	0.02	0.0976	0.1032
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.02	0.0976	0.1032
Echinococcus multilocularis	nuclear receptor nhr 48	0.0095	0.0436	0.0536
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042	0.0169	0.0194
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0095	0.0436	0.0503
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0014	0.0025	0.5
Entamoeba histolytica	protein kinase, putative	0.0038	0.0145	0.5
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0095	0.0436	0.0461
Echinococcus granulosus	roundabout 2	0.0018	0.0045	0.0052
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0014	0.0025	0.5
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.003	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.02	0.0976	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0012
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0014	0.0025	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.02	0.0976	0.1032
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0025	0.0026
Echinococcus granulosus	nuclear receptor nhr 48	0.0095	0.0436	0.0503
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0014	0.0025	0.5
Echinococcus multilocularis		0.0014	0.0025	0.0031
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.1864	0.946	1
Echinococcus granulosus	neuroglian	0.0014	0.0026	0.003
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0095	0.0436	0.0503
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0014	0.0025	0.5
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0014	0.0025	0.5
Loa Loa (eye worm)	DR-78	0.0095	0.0436	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0012
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0014	0.0025	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0025	0.0026
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0014	0.0025	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0095	0.0436	0.0503
Brugia malayi	nuclear hormone receptor family member odr-7	0.0095	0.0436	0.0461
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.02	0.0976	0.1032
Schistosoma mansoni	nuclear receptor nhr-48	0.0095	0.0436	0.0503
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0012	0.0014
Schistosoma mansoni	tyrosine kinase	0.0046	0.0191	0.022
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0046	0.0191	0.0235
Echinococcus multilocularis	c src tyrosine kinase	0.0011	0.0012	0.0014
Brugia malayi	hypothetical protein	0.0106	0.0494	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0095	0.0436	0.0503
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0095	0.0436	0.0536
Brugia malayi	cytochrome P450	0.0014	0.0025	0.0026
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.02	0.0976	0.1199
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1606	0.8144	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0014	0.0025	0.5
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0014	0.0025	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.02	0.0976	0.1124
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0025	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0184	0.0892	0.0943
Echinococcus multilocularis	neuroglian	0.0014	0.0026	0.0032
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0191	0.022
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.02	0.0976	0.1124
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.02	0.0976	0.1124
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0014	0.0025	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.02	0.0976	0.1032
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0046	0.0191	0.022
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042	0.0169	0.0207
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0145	0.0154
Echinococcus multilocularis	FTZ F1 alpha	0.02	0.0976	0.1199
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0157	0.0193
Loa Loa (eye worm)	hypothetical protein	0.177	0.8978	0.949
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Brugia malayi	orphan nuclear receptor NR2E1	0.0095	0.0436	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0047
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042	0.0169	0.0207
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.0145	0.0168
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0014	0.0025	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.02	0.0976	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Schistosoma mansoni	nuclear receptor	0.0095	0.0436	0.0503
Schistosoma mansoni	tyrosine kinase	0.0011	0.0012	0.0013
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0106	0.0494	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0494	0.0522
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.02	0.0976	0.1032
Brugia malayi	hypothetical protein	0.0011	0.0012	0.0012
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0106	0.0494	0.0569
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0012	0.0014
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0095	0.0436	0.0461
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.02	0.0976	0.1032
Schistosoma mansoni	nephrin	0.0014	0.0026	0.003
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0014	0.0025	0.5
Brugia malayi	ecdysone receptor	0.0095	0.0436	0.0461
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0014	0.0025	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0011	0.0012	0.0013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.02	0.0976	0.1032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.02	0.0976	0.1032
Schistosoma mansoni	nuclear receptor	0.0095	0.0436	0.0503
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1712	0.8684	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0014	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0494	0.0522
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0014	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0012
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0095	0.0436	0.0461
Echinococcus multilocularis	thyroid hormone receptor alpha	0.02	0.0976	0.1199
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.02	0.0976	0.1124
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0106	0.0494	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0012
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0014	0.0025	0.5
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0014	0.0025	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0046	0.0191	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0494	0.0522
Loa Loa (eye worm)	nuclear hormone receptor	0.0095	0.0436	0.0461
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0095	0.0436	0.0536
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0014	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0014	0.0025	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.02	0.0976	0.1124
Brugia malayi	nuclear receptor NHR-88	0.0095	0.0436	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.02	0.0976	0.1032
Echinococcus granulosus	tyrosine kinase	0.0042	0.0169	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0012
Schistosoma mansoni	tyrosine kinase	0.0046	0.0191	0.022
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0014	0.0025	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0191	0.0235
Onchocerca volvulus	Tyrosine kinase homolog	0.0172	0.083	0.0412
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.0145	0.0179
Brugia malayi	Fibronectin type III domain containing protein	0.0011	0.0012	0.0012
Brugia malayi	hypothetical protein	0.0106	0.0494	0.0522
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0169	0.0178
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0014	0.0025	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0095	0.0436	0.0503
Schistosoma mansoni	RAR-like nuclear receptor	0.02	0.0976	0.1124
Echinococcus multilocularis	roundabout 2	0.0018	0.0045	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0191	0.0235
Echinococcus granulosus	twitchin	0.0014	0.0026	0.003
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0046	0.0191	0.0235
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.02	0.0976	0.1124
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0046	0.0191	0.022
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0014	0.0025	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.02	0.0976	0.1124
Brugia malayi	steroid hormone receptor	0.02	0.0976	0.1032
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0012	0.0013
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.02	0.0976	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0032
Schistosoma mansoni	nuclear hormone receptor	0.02	0.0976	0.1124
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.02	0.0976	0.1199
Brugia malayi	ecdysteroid receptor	0.02	0.0976	0.1032
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0014	0.0025	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0046	0.0191	0.022
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0494	0.0522
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0014	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0436	0.0461
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.02	0.0976	0.1124
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0011	0.0012	0.0014
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0014	0.0025	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0014	0.0025	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.02	0.0976	0.1032
Loa Loa (eye worm)	hypothetical protein	0.02	0.0976	0.1032
Brugia malayi	Tyrosine-protein kinase abl-1	0.0011	0.0012	0.0012
Brugia malayi	protein-tyrosine kinase	0.0042	0.0169	0.0178

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	< 0.004 uM	In vitro inhibitory concentration of the compound against src-tyrosine kinase	ChEMBL.	14761189
IC50 (binding)	< 0.004 uM	In vitro inhibitory concentration of the compound against src-tyrosine kinase	ChEMBL.	14761189
IC50 (binding)	= 0.1 uM	In vitro inhibitory concentration against VEGF receptor 2.	ChEMBL.	14761189
IC50 (binding)	= 0.1 uM	In vitro inhibitory concentration against VEGF receptor 2.	ChEMBL.	14761189

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL172518
PubChem: 5330182

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 291294