TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.967 | Formula: C27H25ClN4O
H donors: 0 H acceptors: 2 LogP: 4.59 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)N1CCN(CC1=O)Cc1cncn1Cc1ccc(cc1)c1ccccc1
InChi: 1S/C27H25ClN4O/c28-24-7-4-8-25(15-24)32-14-13-30(19-27(32)33)18-26-16-29-20-31(26)17-21-9-11-23(12-10-21)22-5-2-1-3-6-22/h1-12,15-16,20H,13-14,17-19H2
InChiKey: XYYAXYGYXCQAEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Protein farnesyltransferase	Starlite/ChEMBL	References
Homo sapiens	protein geranylgeranyltransferase type I, beta subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Giardia lamblia	Prenyltransferase	Get druggable targets OG5_128081	All targets in OG5_128081
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	Get druggable targets OG5_128081	All targets in OG5_128081
Babesia bovis	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania infantum	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Theileria parva	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_129786	All targets in OG5_129786
Cryptosporidium parvum	protein geranyl-geranyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania donovani	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma mansoni	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus multilocularis	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma japonicum	ko:K05955 protein geranylgeranyltransferase type I, beta subunit [EC:2.5.1.59], putative	Get druggable targets OG5_129786	All targets in OG5_129786
Plasmodium yoelii	Prenyltransferase and squalene oxidase repeat, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium falciparum	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Neospora caninum	protein farnesyltranstransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania major	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei	protein farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei gambiense	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium hominis	chain B, structure of fpt bound to ggpp	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania braziliensis	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative	Get druggable targets OG5_128081	All targets in OG5_128081
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_129786	All targets in OG5_129786
Plasmodium berghei	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania mexicana	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)	Get druggable targets OG5_129786	All targets in OG5_129786
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_129786	All targets in OG5_129786
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Plasmodium knowlesi	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	geranylgeranyl transferase beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)	Get druggable targets OG5_129786	All targets in OG5_129786
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein farnesyltransferase beta subunit	protein geranylgeranyltransferase type I, beta subunit	377 aa	361 aa	26.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0803	0.0679	0.0537
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0379	0.015	0.0277
Brugia malayi	nuclear hormone receptor	0.0803	0.0679	0.0717
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0803	0.0679	0.1255
Echinococcus granulosus	ecdysone induced protein 78C	0.0803	0.0679	0.1255
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0803	0.0679	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0803	0.0679	0.0717
Brugia malayi	ecdysteroid receptor	0.0803	0.0679	0.0717
Loa Loa (eye worm)	steroid hormone receptor	0.0803	0.0679	0.0717
Brugia malayi	conserved hypotetical protein	0.0379	0.015	0.0158
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0803	0.0679	0.1255
Schistosoma mansoni	zinc finger protein	0.0379	0.015	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0207	0.0218
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0803	0.0679	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.7848	0.9471	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0803	0.0679	0.0717
Brugia malayi	hypothetical protein	0.0424	0.0207	0.0218
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0803	0.0679	0.0717
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0803	0.0679	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0803	0.0679	0.1255
Schistosoma mansoni	nuclear hormone receptor	0.0803	0.0679	0.1255
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0424	0.0207	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Brugia malayi	photoreceptor-specific nuclear receptor	0.0803	0.0679	0.0717
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0803	0.0679	0.0717
Schistosoma mansoni	nuclear receptor	0.0379	0.015	0.0277
Brugia malayi	Nuclear hormone receptor E75	0.0379	0.015	0.0158
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0803	0.0679	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0207	0.0218
Brugia malayi	Nuclear hormone receptor-like 1	0.0803	0.0679	0.0717
Brugia malayi	nuclear receptor NHR-67	0.0379	0.015	0.0158
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0379	0.015	0.0277
Brugia malayi	nuclear receptor RXR	0.0424	0.0207	0.0218
Brugia malayi	nuclear hormone receptor family member odr-7	0.0379	0.015	0.0158
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0379	0.015	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0207	0.0218
Brugia malayi	nuclear receptor NHR-88	0.0379	0.015	0.0158
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0803	0.0679	0.1392
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0803	0.0679	0.0717
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0424	0.0207	0.0423
Onchocerca volvulus	Bile acid receptor homolog	0.0803	0.0679	0.0537
Schistosoma mansoni	nuclear receptor	0.0379	0.015	0.0277
Schistosoma mansoni	thyroid hormone receptor	0.0803	0.0679	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Brugia malayi	Nuclear hormone receptor-like 1	0.0424	0.0207	0.0218
Schistosoma mansoni	RAR-like nuclear receptor	0.0803	0.0679	0.1255
Brugia malayi	nuclear receptor NHR-88	0.0803	0.0679	0.0717
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.4595	0.5411	1
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0803	0.0679	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0424	0.0207	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0207	0.0218
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0803	0.0679	0.0717
Brugia malayi	steroid hormone receptor	0.0803	0.0679	0.0717
Brugia malayi	orphan nuclear receptor NR2E1	0.0379	0.015	0.0158
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0379	0.015	0.0277
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0803	0.0679	0.1255
Brugia malayi	ecdysone receptor	0.0379	0.015	0.0158
Schistosoma mansoni	thyroid hormone receptor	0.0803	0.0679	0.1255
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0803	0.0679	0.0717
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0803	0.0679	0.0717
Brugia malayi	hypothetical protein	0.0424	0.0207	0.0218
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0424	0.0207	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Echinococcus granulosus	nuclear receptor nhr 48	0.0379	0.015	0.0277
Echinococcus granulosus	FTZ F1 alpha	0.0803	0.0679	0.1255
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0379	0.015	0.0307
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0803	0.0679	0.0717
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0803	0.0679	0.0717
Schistosoma mansoni	retinoic acid receptor RXR	0.4595	0.5411	1
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Schistosoma mansoni	coup transcription factor	0.0803	0.0679	0.1255
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0803	0.0679	0.0717
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0803	0.0679	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0207	0.0218
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0379	0.015	0.0158
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0379	0.015	0.0307
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0803	0.0679	0.0717
Echinococcus multilocularis	ecdysone induced protein 78C	0.0803	0.0679	0.1392
Loa Loa (eye worm)	hypothetical protein	0.747	0.8998	0.9501
Brugia malayi	hypothetical protein	0.0379	0.015	0.0158
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0803	0.0679	0.1392
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0803	0.0679	0.0717
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0803	0.0679	0.1255
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0803	0.0679	0.1255
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0803	0.0679	0.1392
Onchocerca volvulus	Protein ultraspiracle homolog	0.0803	0.0679	0.0537
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.4171	0.4882	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0424	0.0207	0.0382
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0803	0.0679	0.1392
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0258	0	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0803	0.0679	0.0717
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0803	0.0679	0.1255
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0803	0.0679	0.1255
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0803	0.0679	0.0717
Echinococcus multilocularis	nuclear receptor nhr 48	0.0379	0.015	0.0307
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0763	0.063	0.1164
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0803	0.0679	0.1255
Brugia malayi	hypothetical protein	0.0379	0.015	0.0158
Loa Loa (eye worm)	DR-78	0.0379	0.015	0.0158
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0379	0.015	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0803	0.0679	0.1255
Brugia malayi	Steroid receptor seven-up type 2	0.0803	0.0679	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Brugia malayi	nuclear receptor RXR	0.0379	0.015	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0379	0.015	0.0158
Brugia malayi	nuclear hormone receptor	0.7848	0.9471	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0379	0.015	0.0277
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0803	0.0679	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Loa Loa (eye worm)	nuclear hormone receptor	0.0379	0.015	0.0158
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0379	0.015	0.0277
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0379	0.015	0.0307
Echinococcus multilocularis	FTZ F1 alpha	0.0803	0.0679	0.1392
Brugia malayi	tailless protein	0.0379	0.015	0.0158
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0258	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0803	0.0679	0.1255
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0803	0.0679	0.0717
Brugia malayi	Nuclear hormone receptor-like 1	0.0424	0.0207	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Brugia malayi	Nuclear hormone receptor E75	0.0379	0.015	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0379	0.015	0.0158
Schistosoma mansoni	nuclear receptor nhr-48	0.0379	0.015	0.0277
Schistosoma mansoni	nuclear hormone receptor	0.0379	0.015	0.0277
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0803	0.0679	0.0717
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0803	0.0679	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0803	0.0679	0.0717
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0379	0.015	0.0158
Schistosoma mansoni	nuclear hormone receptor	0.0379	0.015	0.0277

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 12 nM	Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.	ChEMBL.	11965368
IC50 (functional)	= 12 nM	Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.	ChEMBL.	11965368
IC50 (functional)	= 1390 nM	Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-terminus of human K-Ras.	ChEMBL.	11965368
IC50 (functional)	= 1390 nM	Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-terminus of human K-Ras.	ChEMBL.	11965368
IC50 (binding)	= 1600 nM	Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.	ChEMBL.	11965368
IC50 (binding)	= 1600 nM	Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.	ChEMBL.	11965368

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 29156